Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

Abstract

The purpose was to compare global left-ventricular (LV) function parameters measured with cine MRI with results from multiphase dual-source CT (DSCT) using 10 and 20 reconstruction phases. Twenty-eight patients with suspected or known CAD underwent DSCT coronary angiography. LV end-diastolic (EDV), end-systolic (ESV) and stroke volumes (SV), and ejection fraction (EF) were determined using LV segmentation and selection of specific phases from DSCT image sets reconstructed either at 5% or 10% steps through the R-R interval. Cine MRI served as the reference investigation. Threshold-based 3D-segmentation was feasible in all DSCT data sets. EDV and ESV were underestimated by DSCT, but showed excellent correlation (Pearson's correlation coefficient 0.95/0.97) to values obtained with MRI. Using data from 5% DSCT image reconstructions instead of 10% phase reconstructions, the position of the ED and ES phase was changed in 16 of 28 patients; ESVs were to found to be slightly smaller, whereas EDV were slightly larger, resulting in a systematic overestimation of LV EF by 1.9% (p=0.56). Threshold-based 3D segmentation enables accurate and reliable DSCT determination of global LV function with excellent correlation to cine MRI. Minor differences in LV EF indicate that both modalities are virtually interchangeable, even if the number of reconstructed phases is limited to 10% phase reconstructions.

Head-to-Head Comparison of Left Ventricular Function Assessment with 64-Row Computed Tomography, Biplane Left Cineventriculography, and Both 2- and 3-Dimensional Transthoracic Echocardiography

“…In the recent past, 64-row CT has greatly advanced as a noninvasive method for coronary angiography and also has been found to allow accurate assessment of LV function (13)(14)(15)34). For EF, the limits of agreement obtained with 64-row CT (Ϯ14.2%) in comparison with MRI were similar to those reported in previous studies using 64-row CT by Guo Comparative Per-Patient Diagnostic Performance for Regional Function Table 2.…”

Reproducibility of left and right ventricular mass measurements with cardiac CT

“…Several studies have analyzed test performance of this segmentation algorithm for the assessment of cardiac function by comparing it with manual contour tracing, 15,19,20 echocardiography, or MRI, 20,21 but there is a lack of evidence for test performance for mass estimates, and, to the best of our knowledge, none of the existing studies addresses reproducibility between independent scans in the same group of patients.…”

Comparison of MRI, 64-slice MDCT and DSCT in assessing functional cardiac parameters of a moving heart phantom

“…However, reconstructions at intervals of 10% are thought to be adequate for clinical use according to Suzuki et al [27]. In addition, it was reported that DSCT and MRI show similar differences in functional parameters when 10 or 20 phases are used for reconstruction of the DSCT data [28]. …”