Global trends and frontiers in research on coronary microvascular dysfunction: a bibliometric analysis from 2002 to 2022

Abstract

Background Coronary microvascular dysfunction (CMD) is a leading cause of ischemic heart disease. Over the past few decades, considerable progress has been made with respect to research on CMD. The present study summarized the current research hotspots and trends on CMD by applying a bibliometric approach. Methods Relevant publications between 2002 and 2022 were extracted from the Web of Science Core Collection. Visualization network maps of countries, institutions, authors, and co-cited authors were built using VOSviewer. CiteSpace was used for keyword analysis and the construction of a dual-map overlay of journals and a timeline view of co-cited references. Results 1539 CMD-related publications were extracted for bibliometric analysis. The annual publications generally showed an upward trend. The United States of America was the most prolific country, with 515 publications (33.5%). Camici P. G. was the most influential author, whereas the European Heart Journal, Circulation, and Journal of the American College of Cardiology were the most authoritative journals. Research hotspot analysis revealed that endothelial dysfunction as well as reduced nitric oxide production or bioavailability played critical roles in CMD development. Positron emission tomography was the most widely used imaging method for diagnosis. In addition, microvascular angina, hypertrophic cardiomyopathy, and heart failure have attracted much attention as the main clinical implications. Furthermore, international standards for CMD diagnosis and management may be the future research directions. Conclusions This study offers a comprehensive view about the hotspots and development trends of CMD, which can assist subsequent researchers and guide future directions.

Coronary microvascular dysfunction, arrythmias, and sudden cardiac death: A literature review

“…This further solidifies the effect of ischemia on repolarization parameters. However, this pathological mechanism is not limited to macrovascular changes, as coronary microvascular dysfunction has been depicted as a major cause of ischemic heart disease [ 62 , 63 ]. This negative impact on the myocardium is exerted through a demand-supply mismatch, which results in hypoperfusion and ischemia [ 62 ].…”

“…However, this pathological mechanism is not limited to macrovascular changes, as coronary microvascular dysfunction has been depicted as a major cause of ischemic heart disease [ 62 , 63 ]. This negative impact on the myocardium is exerted through a demand-supply mismatch, which results in hypoperfusion and ischemia [ 62 ]. The effect of myocardial ischemia can be seen in patients with microvascular dysfunction through a dynamic rise in QTd during peak exercise [ 58 , 59 ].…”

Analyzing fulminant myocarditis research trends and characteristics using the follower-leading clustering algorithm (FLCA): A bibliometric study

“…Dual-map overlays are frequently created by CiteSpace [22] in bibliographic studies. [26,34,35] These overlays consist of 2 maps: the left map displays the citing journals, while the right map displays the cited journals (note. most often based on research category).…”

“…The resulting enhanced both dual-map overlays and timeline-timezone views for citing/cited articles. We would like to acknowledge the valuable insights provided by the timezone and landscape views [26,34,35,48,49] in CiteSpace software. [22] The citations between the citing and cited articles were incorporated into the enhanced dual-map overlays and timeline-timezone views, as shown in Figures 6 and 8, which have not been demonstrated before in the literature.…”

Insights into research on myocardial ischemia/reperfusion injury from 2012 to 2021: a bibliometric analysis

“…The WoSCC is the most commonly used database for bibliometric analyses. Previous reports have widely confirmed the validity of bibliometric analyses based solely on the WoSCC database [12,13,15]. Therefore, we chose the WoSCC database to retrieve relevant studies using an advanced search strategy.…”