Glomerulosclerosis in Canine Heartworm Infection

Simpson, Charles F.; Gebhardt, Bryan M.; Bradley, Richard E.; Jackson, Richard F. W.

doi:10.1177/030098587401100605

Cited by 17 publications

(6 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The glomerular lesions were considered to represent an immune complex form of glomerulonephritis induced by the D. immitis infection. By contrast, another report [76] considered that the renal lesion in dirofilariasis was a glomerulosclerosis with swelling and fragmentation of the basement membranes accompanied by denudations of endothelial cells with fusion and atrophy of foot processes. The severity of tissue damage was correlated with the degree of microfilaremia.…”

Section: Clomerulonephritis In Dogsmentioning

confidence: 92%

Comparative Pathology of Glomerulonephritis in Animals

Slauson

Lewis

1979

Vet Pathol

View full text Add to dashboard Cite

Abstract. Glomerulonephritis constitutes an important category of renal diseases in animals and has been recognized with increasing frequency in the last decade. We report here the comparative morphologic aspects of glomerulonephritis as a naturally occurring disease of animals. We briefly review the immunopathogenesis of glomerulonephritis. The morphology of renal lesions occurring in glomerulonephritis in dogs, cats, cattle, sheep, horses and swine has been reviewed with emphasis on the range and specificity of various glomerular lesions and on the comparison of lesions between various species. A distinction was made between glornerulonephritis as a primary disease entity and glomerulonephritis associated with other disease processes. Primary idiopathic glomerulonephritis occurred in all species but was most commonly recognized as a clinically important disease in dogs and cats. Glomerulonephritis also occurred in association with other diseases such as equine infectious anemia, chronic hog cholera, canine pyometra, dirofilariasis, feline leukemia virus infection and canine systemic lupus erythematosus.Glomerulonephritis is responsible for substantial morbidity and mortality in many species of animals. Although the cause is basically unknown, it is a disease generally thought to result from the interaction of immunologic and inflammatory reactants at a fixed tissue site (the glomeruli) with subsequent loss of structural and functional integrity of the injured tissues. It is not the purpose of this paper to detail the pathogenesis of glomerulonephritis. For a better understanding of the disease as it occurs in animals, however, it will be useful to review briefly what is known about the pathways potentially leading to glomerular injury [25, 61, 71, 73, 77, 82, 831. Two major immunologic mechanisms of glomerular injury have been identified. In one, antibodies react with antigens in the glomerular basement membrane. In the other, antibodies react with nonglomerular antigens in the circulation to form immune complexes that are deposited in the glomerulus. With conventional light microscopy, it is difficult to infer the pathogenetic mechanisms responsible for glomerulonephritis from the histologic lesion. Differentiating these two mechanisms usually requires fluorescence and electron microscopy. Glomerular lesions induced by soluble immune complexes have characteristic discrete, interrupted, focal deposits of host IgG and complement when examined by fluorescence microscopy. In contrast, the fluorescence staining pattern of glomeruli injured by anti-glomerular basement membrane antibody is uniform, smooth and linear. To further implicate anti-glo- 135

show abstract

Section: Clomerulonephritis In Dogsmentioning

confidence: 92%

Comparative Pathology of Glomerulonephritis in Animals

Slauson

Lewis

1979

Vet Pathol

View full text Add to dashboard Cite

show abstract

“…CROWELL et al (1978) described interstitial nephritis and pyelonephritis in 27% of coyotes infected with D. immitis as compared to a 2% incidence in noninfected coyotes from the same area. A clearer association between interstitial nephritis and D. immitis infections was recently described by SHIEOTA et al, (1979) Demonstrable antigen-antibody complexes were not found in glomeruli of dogs infected with D. immitis with characteristic ultrastructural changes (SIMPSON et al, 1975). These authors suggest that the observed changes are mechanically induced by the microfilaria.…”

Section: Discussionmentioning

confidence: 68%

“…Numerous studies of other host species have also demonstrated that pathological changes occur in other tissues of animals infected with filariae. Of particular interest is the possibility that filariae may induce systemic reactions such as glomerulonephritis (SIMPSON et al, 1972;KLEI et al, 1974), amyloidosis (KLEI et al, 1974;CROWELL et al, 1973;CROVVELL & VOTAVA, 1975), and granuloma formation in various tissues (AH & THOMPSON, 1973;DUKE, 1960;MALONE et al, 1976;WEBB et al, 1960). The present paper reports on kidney, liver, and spleen lesions that have not previously been described in detail or from large numbers of jirds with B. pahangi infections.…”

Section: Introductionmentioning

confidence: 74%

Pathological changes in kidneys, livers and spleens of Brugia pahangi-infected jirds (Meriones unguiculatus)

Klei

Crowell

1981

J. Helminthol.

View full text Add to dashboard Cite

The major organs, other than lymphatics, of jirds (Meriones unguiculatus) with prepatent and chronic patent infections of Brugia pahangi were studied by standard histological, electron microscopical and fluorescent antibody techniques. Changes observed and not previously described in detail or in large numbers of animals are reported. Multifocal non-suppurative interstitial nephritis was observed in 4% of animals with patent infections of 163 days duration and in 69% of animals with patent infections of 274 days duration. Glomerular changes were not observed in kidneys of any animals infected with B. pahangi. The occurrence of large granulomata composed of lymphocytes, macrophages, eosinophils and giant cells in the liver and smaller granulomata in the spleen correlated with patency of infections but microfilariae or worm antigens were not observed in these areas. Amyloid deposits were demonstrated in the spleens of 4% of animals with patent infections of 163 days duration and in 38% of animals with patent infections of 274 days duration but were not seen in uninfected animals of the same age or animals receiving only challenge inoculations of 28 days duration.

show abstract

“…Prominent proteinuria has been reported to occur in a low percentage of dogs infected with D. imm i f i~.~~.~~ The glomerular lesion responsible for the proteinuria is reported to be either an immunecomplex membranous g l~m e r u l o p a t h y l~~~~ or a mechanical injury caused by microfilaria. 16 When the urine electrophoretogram was compared to that ,from serum, a preferential loss of albumin relative to globulin in the urine was apparent in this case. Since no microfilaremia occurred in this animal, an immune-complex glomerulonephritis may have been responsible for the proteinuria.…”

Section: Discussionmentioning

confidence: 78%

Myeloproliferative Disease with Megakaryocytic Predominance in a Dog with Occult Dirofilariasis

Harvey

Henderson

French

et al. 1982

Veterinary Clinical Pathol

View full text Add to dashboard Cite

A 7-year-old male German Shepherd dog with a history of lethargy, weight loss and severe anemia was referred to the University of Florida Veterinary Medical Teaching Hospital for examination. Abnormal laboratory findings included a normocytic and normochromic anemia, thrombocytosis, eosinophilia, basophilia and hyperproteinemia. An increased pulmonary density in the caudal lung lobes was observed on thoracic radiographs. Bone marrow aspiration and core biopsy revealed a hypercellular bone marrow with increased numbers of unidentified blast cells and bizarre megakaryocyte proliferation. Circulating microfilariae were not present in the blood, but serum examined by immunofluorescence was strongly positive for antibodies against Dirofilaria immitis microfilariae. A diagnosis of myeloproliferative disease with megakaryocytic predominance and occult dirofilariasis was made.

show abstract

Glomerulosclerosis in Canine Heartworm Infection

Cited by 17 publications

References 2 publications

Comparative Pathology of Glomerulonephritis in Animals

Comparative Pathology of Glomerulonephritis in Animals

Pathological changes in kidneys, livers and spleens of Brugia pahangi-infected jirds (Meriones unguiculatus)

Myeloproliferative Disease with Megakaryocytic Predominance in a Dog with Occult Dirofilariasis

Contact Info

Product

Resources

About