Glucans from the Caripia montagnei mushroom present anti-inflammatory activity

The contribution of phenolic acids to the anti-inflammatory activity of mushrooms: Screening in phenolic extracts, individual parent molecules and synthesized glucuronated and methylated derivatives

“…Several studies have shown the potential of polysaccharides as anti-inflammatory agents; the methanolic extract of Caripia montagnei (Berk.) Kuntze, was studied and the results suggest that its glucans are effective immunomodulators with anti-inflammatory potential (Queiroz et al, 2010).…”

Anti-inflamatory, anti-angiogenenic and antioxidant activities of polysaccharide-rich extract from fungi Caripia montagnei

“…Polysaccharides (␤-glucans) were obtained by precipitation with methanol, and predominance of sugars was recorded through chemical and structural analyses (previously published by 13 C NMR) and in the present study, by HPLC [6,10]. The extraction method enabled the removal of lipids and phenolic compounds by delipidation, denaturation, and precipitation of proteins.…”

“…The polymer was previously analyzed by NMR of 13 C and signals obtained confirmed it as polysaccharide [6]. In this work, HPLC of the polysaccharide was performed with a refractive index detector.…”

“…Different concentrations of the total polysaccharide fraction (0.007 to 4 mg/mL) were incubated with PBS buffer (0.2 M, pH 6.6) and 1% potassium ferricyanide [K 3 Fe (CN) 6 ] at 50 • C. This was then added to TCA and centrifuged at 3000 g for 10 min. Next, 2.5 mL water and 0.5 mL of ferric chloride (0.1%) were added to the supernatant.…”

“…However, the mechanisms of this process are still unclear. Moreover, research on paw edema inhibition has demonstrated that the activation of PPAR␥ receptors may also contribute to antiangiogenic action of its ligands (agonists), which, once activated, inhibit angiogenesis through the modulation of cytokines [6,7].…”