Glucocorticoids in adult cardiac surgery; old drugs revisited

Zakkar, Mustafa; Kanagasabay, Robin

doi:10.1177/0267659113488433

Cited by 5 publications

(2 citation statements)

References 68 publications

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“…The administration of corticosteroids before CPB may reduce the activation of multiple proinflammatory mediators. The translation of proinflammatory mediator's changes into clinical outcomes remains controversial and most of the evidence in the literature originates from small RCTs or observational studies with biomarkers as primary end points [ 62 , 63 ].…”

Section: Pulmonary Protection Strategiesmentioning

confidence: 99%

Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress?

Jaaly

Zakkar

Fiorentino

et al. 2015

Oxidative Medicine and Cellular Longevity

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Pulmonary dysfunction is a common complication of cardiac surgery. The mechanisms involved in the development of pulmonary dysfunction are multifactorial and can be related to the activation of inflammatory and oxidative stress pathways. Clinical manifestation varies from mild atelectasis to severe respiratory failure. Managing pulmonary dysfunction postcardiac surgery is a multistep process that starts before surgery and continues during both the operative and postoperative phases. Different pulmonary protection strategies have evolved over the years; however, the wide acceptance and clinical application of such techniques remain hindered by the poor level of evidence or the sample size of the studies. A better understanding of available modalities and/or combinations can result in the development of customised strategies for the different cohorts of patients with the potential to hence maximise patients and institutes benefits.

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Section: Pulmonary Protection Strategiesmentioning

confidence: 99%

Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress?

Jaaly

Zakkar

Fiorentino

et al. 2015

Oxidative Medicine and Cellular Longevity

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“…Anti‐inflammatory drugs are the most commonly used drugs for postoperative pain treatment. However, due to their adverse effects, their use is limited in patients who have undergone cardiac surgery 6,9 …”

Section: Introductionmentioning

confidence: 99%

Bupivacaine infiltration for acute postoperative pain management after cardiac surgery

Oliveros

Osa

2021

Nursing in Critical Care

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Background: Despite increased attention, acute and persistent post-operative pain are not treated efficiently and interventions against acute pain are therefore of clinical importance and should be welcomed. Aims and objectives:To evaluate the effectiveness of wound infiltration with 0.5% bupivacaine for pain management in the immediate post-operative period in patients that underwent cardiac surgery with sternotomy. Design:The study was performed employing a single-centre nonrandomized experimental design to evaluate a prospective cohort of patients recruited from June to December of 2017.Methods: A single-centre study with a non-randomized experimental design compared the pain perceived by 137 patients undergoing to cardiac surgery within which 68 patients who received infiltration of bupivacaine and 69 patients received infiltration with saline solution. Pain measures were made with the numeric rating scale (NRS) at 2, 12, 24, and 48 hours. Socio-demographic and clinical variables were included too and descriptive, bivariate, and multivariate logistic regression analyses were performed.Results: A statistically significant difference was found between the means of the NRS scores in favour of the intervention group. Cohen's d showed a significant effect size. NRS scores were grouped into NRS ≥4 or NRS <4 and similar results were found. Multivariate logistic regression analyses showed the absence of confounding factors that could call results into question. Conclusion:Subcutaneous infiltration of 0.5% bupivacaine in the surgical site of patients who have undergone cardiac surgery showed clinically and statistically significant pain relief compared with patients who received saline infiltration throughout the first 12 hours after surgery. This intervention provides promising preliminary results that, alone or in conjunction with other nursing interventions, could constitute an important therapeutic tool for this area of nursing clinical practice.

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Myeloperoxidase in the pericardial fluid improves the performance of prediction rules for postoperative atrial fibrillation

Liu

Yu²,

et al. 2023

The Journal of Thoracic and Cardiovascular Surgery

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Glucocorticoids in adult cardiac surgery; old drugs revisited

Cited by 5 publications

References 68 publications

Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress?

Pulmonary Protection Strategies in Cardiac Surgery: Are We Making Any Progress?

Bupivacaine infiltration for acute postoperative pain management after cardiac surgery

Myeloperoxidase in the pericardial fluid improves the performance of prediction rules for postoperative atrial fibrillation

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