Glucose lowering activities of mombintane I and mombintane II isolated from the leaves of Spondias mombin L

Abstract

The uses of Spondias mombin Linn in folk medicine as part of recipe for the management and treatment of Diabetes mellitus are well documented. This has been investigated and proven using various experimental models. The aim of this study was to report two isolated compounds from S. mombin leaves probably exhibiting synergistic glucose lowering effects in the in vitro model. The in vitro α-amylase inhibitory assay was used to establish the glucose lowering activities of the isolated compounds while, the isolated compounds were determined from the spectra of their MS, IR and proton NMR. It was established that they are sterols with molecular formula C 29 H 52 O 2 and C 29 H 50 O. The two compounds exhibited a synergistic effect of 61% αamylase inhibitory activity. This study shows that mombintane I and mombintane II exhibit synergistic effect in lowering blood glucose levels.