Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes

Messier, Claude; Gagnon, Marc‐André

doi:10.1016/0166-4328(95)00153-0

Cited by 223 publications

(150 citation statements)

References 106 publications

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“…Such metabolic and oxidative compromise, known to exist in AD (219,238,269), may thereby render neurons susceptible to excitotoxicity and apoptosis. The oxidative modification of energy-related proteins correlates with the altered energy metabolism reported in brain in MCI and AD, which can contribute to neurodegeneration (165,272). These results support the notion that energy metabolism is a key feature in the progression of AD pathogenesis.…”

Section: Identification Of Carbonylated Proteins In Brainsupporting

confidence: 76%

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield

Perluigi

Reed

et al. 2012

Antioxidants & Redox Signaling

157

142

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Several studies demonstrated that oxidative damage is a characteristic feature of many neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt cellular functions by affecting protein expression, protein turnover, cell signaling, and induction of apoptosis and necrosis, suggesting that protein oxidation could have both physiological and pathological significance. For nearly two decades, our laboratory focused particular attention on studying oxidative damage of proteins and how their chemical modifications induced by reactive oxygen species/reactive nitrogen species correlate with pathology, biochemical alterations, and clinical presentations of Alzheimer's disease. This comprehensive article outlines basic knowledge of oxidative modification of proteins and lipids, followed by the principles of redox proteomics analysis, which also involve recent advances of mass spectrometry technology, and its application to selected age-related neurodegenerative diseases. Redox proteomics results obtained in different diseases and animal models thereof may provide new insights into the main mechanisms involved in the pathogenesis and progression of oxidativestress-related neurodegenerative disorders. Redox proteomics can be considered a multifaceted approach that has the potential to provide insights into the molecular mechanisms of a disease, to find disease markers, as well as to identify potential targets for drug therapy. Considering the importance of a better understanding of the cause/effect of protein dysfunction in the pathogenesis and progression of neurodegenerative disorders, this article provides an overview of the intrinsic power of the redox proteomics approach together with the most significant results obtained by our laboratory and others during almost 10 years of research on neurodegenerative disorders since we initiated the field of redox proteomics. Antioxid. Redox Signal. 17, 1610-1655.

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Section: Identification Of Carbonylated Proteins In Brainsupporting

confidence: 76%

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Butterfield

Perluigi

Reed

et al. 2012

Antioxidants & Redox Signaling

157

142

View full text Add to dashboard Cite

show abstract

“…The rationale for theories which implicated glucose as a potential cognitive enhancer in elderly individuals was that ageing is accompanied by neuroendocrine dysregulation , including deficiencies in the regulation of key hormones involved in both memory storage and glucose regulation, such as adrenaline (Gold, 2005;Korol and Gold, 1998). In addition, poor glucose regulation is particularly prevalent in older individuals (Awad et al, 2002;Messier, 2004Messier, , 2005Messier and Gagnon, 1996;Parsons and Gold, 1992). Table 1 displays the findings of studies which have specifically investigated the influence of oral glucose ingestion in healthy elderly individuals (versus saccharin placebo) on various measures 5 of neurocognitive performance.…”

Section: Glucose Memory and 'Healthy' Ageingmentioning

confidence: 99%

“…It is unsurprising that glucose has been investigated as a possible cognitive enhancer in patients suffering from Alzheimer's disease, given that this condition is associated with glucoregulatory abnormalities (Messier and Gagnon, 1996;Watson and Craft, 2004). Three key studies have specifically investigated whether glucose influences memory performance in patients with Alzheimer's disease.…”

Section: Alzheimer's Diseasementioning

confidence: 99%

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Smith

Riby

Eekelen

et al. 2011

Neuroscience & Biobehavioral Reviews

133

123

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The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning. This phenomenon has been termed the 'glucose memory facilitation effect'. The purpose of this review is to discuss a number of salient studies which have investigated the influence of glucose ingestion on neurocognitive performance in individuals with a) compromised neurocognitive capacity, as well as b) normally functioning individuals (with a focus on research conducted with human participants). The proposed neurocognitive mechanisms purported to underlie the modulatory effect of glucose on neurocognitive performance will also be considered. Many theories have focussed upon the hippocampus, given that this brain region is heavily implicated in learning and memory. Further, it will be suggested that glucose is a possible mechanism underlying the phenomenon that enhanced memory performance is typically observed for emotionally laden stimuli.

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“…The notion that the hippocampus is directly involved in mediating the glucose memory facilitation effect is supported by observations that the hippocampus is densely populated with insulin receptors relative to many other brain regions (Lathe 2001). Further, glucose has been associated with increased hippocampal acetylcholine synthesis (Messier and Gagnon 1996). However, the hippocampus hypothesis does not account well for previous study findings in which non-memory tasks are improved by glucose (e.g.…”

mentioning

confidence: 91%

Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents

et al. 2009

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Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes

Cited by 223 publications

References 106 publications

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Redox Proteomics in Selected Neurodegenerative Disorders: From Its Infancy to Future Applications

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

Glucose modulates event-related potential components of recollection and familiarity in healthy adolescents

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