We analyse the sensitivity of quark flavour-changing observables to the MSSM, in a regime of heavy superpartner masses. We analyse four distinct and motivated frameworks characterising the structure of the soft-breaking terms by means of approximate flavour symmetries. We show that a set of six low-energy observables with realistic chances of improvement in the near future, namely ∆M s,d , K , K / K , B(K → πνν), and the phase of D-D mixing, could play a very important role in charactering these frameworks in a regime of superpartner masses up to O(100) TeV. We show that these observables remain very interesting even in a long-term perspective, i.e. even taking into account the direct mass reach of the most ambitious future high-energy colliders. *