Glutathione Peroxidase Activity Modulates Fatty Acid Profiles of Plasma and Breast Milk in Chinese Women

Dodge, M.L.; Wander, Rosemary C.; Xia, Yiming; Butler, Jane; Whanger, P. D.

doi:10.1016/s0946-672x(99)80062-5

Cited by 19 publications

(12 citation statements)

References 21 publications

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“…After 3 months of Se supplementation (50 mg/d selenomethionine), milk Se of New Zealand mothers increased significantly, but the increase in GPX activity was not significant (Dodge et al 1999). Dodge et al (1998) observed that in early lactation (1 -7 d) of Chinese mothers, even in the presence of significantly low milk Se concentrations there was no difference in milk GPX activity between low and high intakes of habitual dietary Se. Similar observations were made by Moore et al (2000) after supplementation with 100 mg Se (selenomethionine from yeast)/d of Chinese mothers with habitually low Se intake.…”

Section: Selenium Prophylaxis and Breast-feedingmentioning

confidence: 85%

“…Se in natural foods consumed by Chinese mothers from Xichang (low-Se region) and Enshi (high-Se region) provinces showed differences in total Se (0·26 v. 1·0 mmol/l respectively), but similar GPX activity in early breast-milk (1 -7 d). However, in late lactation (2 -10 months), the milk GPX activity in mothers from Xichang had decreased to significantly lower levels (Dodge et al 1998). Absorption, retention and utilization (appearance in milk) were greater in a selenomethionine-than in a selenite-supplemented group (Mangels et al 1990;Moser-Veillon et al 1992;Trafikowska et al 1998).…”

Section: Selenium Species In Breast Milkmentioning

confidence: 96%

“…Besides the complexity of food Se composition and bioavailability, the methods used to estimate maternal Se intake varied among studies. Dodge et al (1998) reported results from studies by others. Bratter et al (1991b ) used extrapolation of Se intake v. breast-milk Se reported in several countries and claimed a linear relationship, which was used to estimate maternal daily Se intake in their study (Bratter et al 1991a).…”

Section: Environmental Factorsmentioning

confidence: 99%

“…Dodge et al (1999) reported that maternal Se supplementation (50 mg/d as selenomethionine) increased the polyunsaturated fatty acids (especially linoleic acid) and decreased saturated fatty acids in breast milk. Dodge et al (1998), studying Se metabolism in seleniferous areas of China, reported that milk linoleic acid was also high in the women from Enshi (extremely high Se intake). A discrepant report of this trend was the study of Moore et al (2000) in Chinese mothers from a low-Se area.…”

Section: Selenium Interactions and Breast-feedingmentioning

confidence: 99%

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Selenium and breast-feeding

Dórea

2002

Br J Nutr

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The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and selenoamino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4 -32 % total Se) . selenocystamine . selenocystine . selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 mg/l in colostrum (0 -5 d), transitional milk (6 -21 d), mature milk (1 -3 months) and late lactation (.5 months) respectively. Se recommendations for infants are presently not achieved in 30 % of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

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Section: Selenium Prophylaxis and Breast-feedingmentioning

confidence: 85%