Glutathione S-transferases in human ovarian follicular fluid

Bisseling, Jan G.A.; Knapen, Maarten F. C. M.; Goverde, H.J.M.; Mulder, T.P.J.; Peters, Wilbert H.M.; Willemsen, Wim N.P.; Thomas, Chris M.G.; Steegers, Eric A.P.

doi:10.1016/s0015-0282(97)00334-8

Cited by 14 publications

(8 citation statements)

References 21 publications

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“…Although we did not measure glutathione levels, our GPX, GST, and GR activities did not suggest a critical role for glutathione metabolism influencing embryo quality similar to previous reports (11). We identified GST activities to be higher in FF than serum, confirming prior findings that demonstrated local production of GST by granulosa cells (33). Carbone et al (10) found increased SOD and reduced GST activities in older women; however, no differences in GPX or GR activities were seen.…”

Section: Discussionsupporting

confidence: 88%

Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization

Fujimoto

Bloom

Huddleston

et al. 2011

Fertility and Sterility

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Section: Discussionsupporting

confidence: 88%

Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization

Fujimoto

Bloom

Huddleston

et al. 2011

Fertility and Sterility

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“…Glutathione and glutathione-related enzymes are involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species in the human ovary. 25 As in other spectroscopic analysis, unassigned resonances were found. Some of the metabolites causing these resonances can also be detected in urine, blood plasma or cerebrospinal fluid.…”

Section: Metabolitesupporting

confidence: 55%

High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid

et al. 2000

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“…The GSTM1 gene has 2 variants, and encodes an enzyme that participates in the metabolism of carcinogens [12]. The absence of GSTM1 enzymes has been associated with malignant transformation of ovarian cells [13]. XRCC1 is a base excision repair and single-strand break repair protein that may play an important role in resistance to a variety of DNA damaging agents [14].…”

Section: Introductionmentioning

confidence: 99%

Impact of XRCC1, GSTP1, and GSTM1 Polymorphisms on the Survival of Ovarian Carcinoma Patients Treated with Chemotherapy

Zhai

Huang²,

Wu³

et al. 2016

Oncol Res Treat

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Background: Single nucleotide polymorphic variants of DNA repair genes may improve drug efficacy through altering expression levels of the encoded proteins. This study evaluated the influence of genetic polymorphism GSTP1 Ile105Val, GSTM1 (null/non-null) and 2 XRCC1 polymorphisms (Arg194Trp and Arg399Gln) on the survival of ovarian carcinoma patients treated with chemotherapy. Methods: 106 patients received treatment with a carboplatin-based or alternative chemotherapy. Polymorphisms were genotyped by pyrosequencing. Results: The genotypes XRCC1 194Arg/Trp and XRCC1 194Trp/Trp conferred no significant risk of death when compared to 194Arg/Arg (hazard ratio (HR) 1.01, 95% confidence interval (CI) 0.33-3.09, and HR 0.89, 95% CI 0.31-2.57, respectively). Similarly, those carrying the XRCC1 399Arg/Gln genotype had no increased risk of death compared to the XRCC1 399Arg/Arg (HR 0.85, 95% CI 0.39-1.86); no homozygous carriers of the glutamine allele (XRCC1 399 Gln/Gln) were detected. The GSTP1 105Ile/Val had no increased risk of death compared to the GSTP1 105Ile/Ile (HR = 1.20, 95% CI = 0.55-2.63) and no homozygous carriers of the valine allele (GSTP1 105Val/Val) were detected in the study. Compared to the non-null genotype of GSTM1, the mortality rate was nonsignificantly reduced in patients with the null genotype (HR 1.07, 95% CI 0.48-2.42). However, overall survival of the patients treated with the carboplatin-based regimen was significantly longer than for those treated with alternative chemotherapy (p_log-rank = 0.006). Conclusions: The present findings suggest that there are no correlations between genotypes and survival.

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Glutathione S-transferases in human ovarian follicular fluid

Cited by 14 publications

References 21 publications

Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization

Correlations of follicular fluid oxidative stress biomarkers and enzyme activities with embryo morphology parameters during in vitro fertilization

High-resolution proton nuclear magnetic resonance spectroscopy of ovarian cyst fluid

Impact of XRCC1, GSTP1, and GSTM1 Polymorphisms on the Survival of Ovarian Carcinoma Patients Treated with Chemotherapy

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