1979
DOI: 10.1093/bja/51.9.885
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Glycopyrrolate as a Premedicant: Comparison With Atropine

Abstract: A double-blind comparison of glycopyrrolate with atropine as the anticholinergic component of premedication was made in 200 patients undergoing minor or intermediate surgical procedures. Glycopyrrolate was associated with a smaller increase in heart rate, but there was no difference between the drugs in respect of cardiac arrhythmia, change in arterial pressure, control of secretions in the upper respiratory tract, frequency of nausea and vomiting after operation or subjective well-being of the patients.

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Cited by 25 publications
(10 citation statements)
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“…In doses assumed to be equipoint with respect to acceleration of H R during anaesthesia (1), the two test drugs were followed by the same acceleration of H R before induction. Most previous studies reported an increase in H R by atropine only ( 7 , 12,13), but Lischke et al, studying the same doses, reported findings similar to those of the present study (14). Unfortunately, levels of significance were not stated.…”
Section: Discussioncontrasting
confidence: 45%
“…In doses assumed to be equipoint with respect to acceleration of H R during anaesthesia (1), the two test drugs were followed by the same acceleration of H R before induction. Most previous studies reported an increase in H R by atropine only ( 7 , 12,13), but Lischke et al, studying the same doses, reported findings similar to those of the present study (14). Unfortunately, levels of significance were not stated.…”
Section: Discussioncontrasting
confidence: 45%
“…Die Frage nach Nutzen, Bedeutung und Notwendigkeit einer anticholinergen Prämedikation wird nach wie vor kontrovers diskutiert (2). Den erwünschten Wirkungen einer solchen Prämedikation, nämlich der Schutz vor einer Bradycardie (2) und der verminderten Bronchial-und Speichelsekretion (9, 10, ll), stehen Nebenwirkungen wie Tachycardie, unangenehme Empfindungen und eine mögliche Hyperthermie bei Kindern gegenüber (7,9,12). Eine in diesem Zusammenhang selten erwähnte Wirkung der anticholinergen Prämedikation ist eine Hemmung der Magensaftsekretion, die sich in Reduzierung von Magensaftvolumen und Säureproduktion äußert (3, 5).…”
Section: Introductionunclassified
“…Glycopyrrolate, with its quaternary nitrogen, penetrates the central nervous system poorly (5). Accordingly it is claimed to be devoid of central sedative actions, although there are reports of drowsiness and even frank CAS after its administration ( 14,15). Postoperative responsiveness to verbal and painful stimuli has been claimed to be better (1 6), awakening from anaesthesia marginally quicker (1 7) and psychomotor performance better ( 18) after glycopyrrolate-neostigmine than after atropineneostigmine.…”
Section: Discussionmentioning
confidence: 99%