“Going Long”: Long Non-Coding RNAs as Biomarkers

Skroblin, Philipp; Mayr, Manuel

doi:10.1161/circresaha.114.304839

Cited by 44 publications

(31 citation statements)

References 17 publications

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“…Furthermore, in a recent research, HOXA11‐AS has been reported to promote proliferation, migration and inflammation‐related gene expression, thereby spurring inflammation in diabetic arteriosclerosis . The phenomenon in which HOXA11‐AS exhibits divergent functions in different diseases may be explained by tissue‐ and cell‐type‐specific lncRNAs . In the present study, the expression of HOXA11‐AS was significantly up‐regulated by CaOx crystals in vivo and in vitro (Figure ), consistent with our previous microarray analysis.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, HOXA11‐AS has been suggested to delay fracture healing via sponging miR‐124‐3p and to promote diabetic arteriosclerosis–related inflammation through the PI3K/AKT pathway . Taken together, these findings reveal that HOXA11‐AS functions in a tissue‐ and cell‐type‐specific manner like other lncRNAs . However, its biological function in calcium oxalate crystal–induced renal injury remains poorly defined.…”

Section: Introductionmentioning

confidence: 83%

“…13 The phenomenon in which HOXA11-AS exhibits divergent functions in different diseases may be explained by tissue-and cell-type-specific lncRNAs. 14 To identify downstream genes of HOXA11-AS, we compared a previous microarray analysis conducted to investigate CaOx stonerelated mRNAs using the same animal model 16 with another recent F I G U R E 5 MiR-124-3p directly binds to HOXA11-AS and the 3′UTR of MCP-1. A, Venn diagram for miRNAs predicted to target HOXA11-AS and MCP-1 3′UTR by different online tools.…”

Section: Discussionmentioning

confidence: 99%

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LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

Yan

Zhang

et al. 2019

J Cellular Molecular Medi

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Long noncoding RNA (lncRNA) has been suggested to play an important role in a variety of diseases over the past decade. In a previous study, we identified a novel lncRNA, termed HOXA11‐AS, which was significantly up‐regulated in calcium oxalate (CaOx) nephrolithiasis. However, the biological function of HOXA11‐AS in CaOx nephrolithiasis remains poorly defined. Here, we demonstrated that HOXA11‐AS was significantly up‐regulated in CaOx nephrolithiasis both in vivo and in vitro. Gain‐/loss‐of‐function studies revealed that HOXA11‐AS inhibited proliferation, promoted apoptosis and aggravated cellular damage in HK‐2 cells exposed to calcium oxalate monohydrate (COM). Further investigations showed that HOXA11‐AS regulated monocyte chemotactic protein 1 (MCP‐1) expression in HK‐2 cell model of CaOx nephrolithiasis. In addition, online bioinformatics analysis and dual‐luciferase reporter assay results showed that miR‐124‐3p directly bound to HOXA11‐AS and the 3'UTR of MCP‐1. Furthermore, rescue experiment results revealed that HOXA11‐AS functioned as a competing endogenous RNA to regulate MCP‐1 expression through sponging miR‐124‐3p and that overexpression of miR‐124‐3p restored the inhibitory effect of proliferation, promotion effects of apoptosis and cell damage induced by HOXA11‐AS overexpression. Taken together, HOXA11‐AS mediated CaOx crystal–induced renal inflammation via the miR‐124‐3p/MCP‐1 axis, and this outcome may provide a good potential therapeutic target for nephrolithiasis.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

Yan

Zhang

et al. 2019

J Cellular Molecular Medi

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“…Since CoroMarker is located mainly in the extracellular vesicle, probably from monocytes, it is stable in plasma and easy to evaluate as a biomarker [83]. Many other lncRNAs are also reported as potential biomarkers for cardiovascular disease [84]. LncRNA LIPCAR has been identified from the plasma of myocardial infarction patients [85].…”

Section: Therapeutic Usementioning

confidence: 99%

LncRNA as a Therapeutic Target for Angiogenesis

Kumar

Goyal

2017

CTMC

213

152

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Background: Out of 3 billion base pairs in human genome only ~2% code for proteins; and out of 180,000 transcripts in human cells, about 20,000 code for protein, remaining 160,000 are non-coding transcripts. Most of these transcripts are more than 200 base pairs and constitute a group of long non-coding RNA (lncRNA). Many of the lncRNA have its own promoter, and are well conserved in mammals. Accumulating evidence indicates that lncRNAs act as molecular switches in cellular differentiation, movement, apoptosis, and in the reprogramming of cell states by altering gene expression patterns. However, the role of this important group of molecules in angiogenesis is not well understood. Angiogenesis is a complex process and depends on precise regulation of gene expression. Conclusion:Dysregulation of transcription during this process may lead to several diseases including various cancers. As angiogenesis is an important process in cancer pathogenesis and treatment, lncRNA may be playing an important role in angiogenesis. In support of this, lncRNA microvascular invasion in hepatocellular carcinoma (MVIH) has been shown to activate angiogenesis. Furthermore, lncRNA-Meg3-knockout mouse showed increased expression of vascular endothelial growth factor pathway genes and increased cortical microvessel density. Overall, there is strong evidence that lncRNA is an important class of regulatory molecule, and a number of studies have demonstrated that these can be targeted to change cellular physiology and functions. In this review, we have attempted to summarize these studies and elucidate the potential of this novel regulatory molecule as a therapeutic target.

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“…The key portion of the SNPs in the 9p21 locus overlaps with 13‐19 exons in ANRIL . ANRIL, also known as CDKN2B‐AS or CDKN2B‐AS1, is transcribed in the antisense direction of the INK4b‐ARF‐INK4a gene cluster . Accumulating evidence has demonstrated that ANRIL is expressed in vascular endothelial cells (VECs), vascular smooth muscle cells (VSMCs), mononuclear phagocytes and AS plaques .…”

Section: What Is Known and Objectivementioning

confidence: 99%

ANRIL and atherosclerosis

Chen

Guo

et al. 2019

J Clin Pharm Ther

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What is known and objective The 3.8‐kb‐long antisense non‐coding RNA at the INK4 locus (ANRIL) is transcribed from the short arm of human chromosome 9 on P21 and is associated with malfunction of the vascular endothelium, vascular smooth muscle cell (VSMC) proliferation/migration/senescence/apoptosis, mononuclear cell adhesion and proliferation, glycolipid metabolism disorder and DNA damage. Hence, ANRIL plays an important role in atherogenesis. Moreover, genome‐wide association studies (GWAS) have identified ANRIL as a biomarker that is closely related to coronary heart disease (CHD). The objective of this review was to discuss the pathological mechanism of ANRIL in atherosclerotic development and its significance as a predictor of cardiovascular disease. Methods Review of the PubMed, EMBASE and Cochrane databases for articles demonstrating the roles of ANRIL in the development of atherosclerotic diseases. Results and discussion The abnormal expression of ANRIL is linked to vascular endothelium injury; the proliferation, migration, senescence and apoptosis of VSMCs; mononuclear cell adhesion and proliferation; glycolipid metabolism disorder; DNA damage; and competing endogenous RNAs. Moreover, ANRIL accelerates the progression of CHD by regulating its single nucleotide polymorphisms (SNPs). What is new and conclusion Considering that ANRIL accelerates atherosclerosis (AS) development and is a risk factor for CHD, it is reasonable for us to explore an efficacious ANRIL‐based therapy for AS in CHD.

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“Going Long”: Long Non-Coding RNAs as Biomarkers

Cited by 44 publications

References 17 publications

LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

LncRNA HOXA11‐AS regulates calcium oxalate crystal–induced renal inflammation via miR‐124‐3p/MCP‐1

LncRNA as a Therapeutic Target for Angiogenesis

ANRIL and atherosclerosis

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