Gold coated electrospun polymeric fibres as new electrode platform for glucose oxidase immobilization

Aldea, Anca; Leote, Ricardo J.B.; Matei, Elena; Evanghelidis, Alexandru; Enculescu, Ionuţ; Diculescu, Victor C.

doi:10.1016/j.microc.2021.106108

Cited by 15 publications

(16 citation statements)

References 59 publications

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“…Additionally, the Au/TPU NFs could be used to simultaneously measure pH and other sweat analytes by utilizing different functionalizations and other sensing techniques. For example, Aldea et al developed an electrochemical sweat glucose sensor using Au-coated electrospun NFs . This shows the potential to functionalize the Au/TPU NFs with both 4-MBA/4-MPy and the glucose-sensitive enzyme, glucose oxidase, to form an integrated optical/electrochemical sensor capable of simultaneously sensing sweat glucose and sweat pH for real-time calibration.…”

Section: Resultsmentioning

confidence: 99%

“…For example, Aldea et al developed an electrochemical sweat glucose sensor using Au-coated electrospun NFs. 46 This shows the potential to functionalize the Au/TPU NFs with both 4-MBA/4-MPy and the glucose-sensitive enzyme, glucose oxidase, to form an integrated optical/electrochemical sensor capable of simultaneously sensing sweat glucose and sweat pH for real-time calibration. Alternatively, glucose could also potentially be detected using the SERS-active Au/TPU NFs by utilizing boronic acids as the sensitive molecules, as demonstrated in work by Sharma et al 47 Furthermore, the ability of the SERSactive Au/TPU NFs to accurately measure pH from low volumes of liquid could be applied to sensing using other biofluids such as blood, tears, saliva, and urine.…”

Section: Wettability Of Sers-activementioning

confidence: 99%

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Fabrication of a Wearable Flexible Sweat pH Sensor Based on SERS-Active Au/TPU Electrospun Nanofibers

Chung

Skinner

Robert

et al. 2021

ACS Appl. Mater. Interfaces

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Development of wearable sensing platforms is essential for the advancement of continuous health monitoring and point-of-care testing. Eccrine sweat pH is an analyte that can be noninvasively measured and used to diagnose and aid in monitoring a wide range of physiological conditions. Surface-enhanced Raman scattering (SERS) offers a rapid, optical technique for fingerprinting of biomarkers present in sweat. In this paper, a mechanically flexible, nanofibrous, SERS-active substrate was fabricated by a combination of electrospinning of thermoplastic polyurethane (TPU) and Au sputter coating. This substrate was then investigated for suitability toward wearable sweat pH sensing after functionalization with two commonly used pH-responsive molecules, 4-mercaptobenzoic acid (4-MBA), and 4-mercaptopyridine (4-MPy). The developed SERS pH sensor was found to have good resolution (0.14 pH units for 4-MBA; 0.51 pH units for 4-MPy), with only 1 μL of sweat required for a measurement, and displayed no statistically significant difference in performance after 35 days (p = 0.361). Additionally, the Au/TPU nanofibrous SERS pH sensors showed fast sweat-absorbing ability as well as good repeatability and reversibility. The proposed methodology offers a facile route for the fabrication of SERS substrates which could also be used to measure a wide range of health biomarkers beyond sweat pH.

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Section: Resultsmentioning

confidence: 99%

Section: Wettability Of Sers-activementioning

confidence: 99%

Fabrication of a Wearable Flexible Sweat pH Sensor Based on SERS-Active Au/TPU Electrospun Nanofibers

Chung

Skinner

Robert

et al. 2021

ACS Appl. Mater. Interfaces

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“…Various electrospinning processes with polymer materials and functional ingredients have been applied to glucose sensors. At present, a variety of polymer materials have been tried as scaffold materials and different properties of functional ingredients have been introduced, but the preparation of glucose sensors still mostly uses single-fluid electrospinning ( Aldea et al, 2021 ; Li Jinze et al, 2021 ). Multiple-fluid electrospinning processes are less used in the development of glucose sensors, and therefore they have high application development value in the future.…”

Section: Electrospun Glucose Sensorsmentioning

confidence: 99%

Electrospun nanofiber-based glucose sensors for glucose detection

Zhang

Liu

et al. 2022

Front. Chem.

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Diabetes is a chronic, systemic metabolic disease that leads to multiple complications, even death. Meanwhile, the number of people with diabetes worldwide is increasing year by year. Sensors play an important role in the development of biomedical devices. The development of efficient, stable, and inexpensive glucose sensors for the continuous monitoring of blood glucose levels has received widespread attention because they can provide reliable data for diabetes prevention and diagnosis. Electrospun nanofibers are new kinds of functional nanocomposites that show incredible capabilities for high-level biosensing. This article reviews glucose sensors based on electrospun nanofibers. The principles of the glucose sensor, the types of glucose measurement, and the glucose detection methods are briefly discussed. The principle of electrospinning and its applications and advantages in glucose sensors are then introduced. This article provides a comprehensive summary of the applications and advantages of polymers and nanomaterials in electrospun nanofiber-based glucose sensors. The relevant applications and comparisons of enzymatic and non-enzymatic nanofiber-based glucose sensors are discussed in detail. The main advantages and disadvantages of glucose sensors based on electrospun nanofibers are evaluated, and some solutions are proposed. Finally, potential commercial development and improved methods for glucose sensors based on electrospinning nanofibers are discussed.

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“…Aldea et coworkers [155] produced fibers of poly(methyl methacrylate) by electrospinning and then coated them with a gold layer and attached them on a thin polyethylene terephthalate substrate in order to obtain flexible electrodes for biosensing applications. Another group of researchers reported the obtaining of electrospun fibers from bioabsorbable polymers such as polycaprolactone (PCL) [156], poly(lactic-co-glycolic acid) (PLGA) [157], and poly(lactic acid)/poly(hydroxibutyrate) (PLA-PHB) [158]; natural polymers such as chitosan and gelatin; and blends of bioabsorbable [159] and natural polymers (PCL/PLGA [160] and PCL/chitosan) [161].…”

Section: Effects Of Surface Properties On Biological Responses Of The...mentioning

confidence: 99%

Surface Functionalities of Polymers for Biomaterial Applications

Drobotă¹,

Ursache²,

Aflori³

2022

Polymers

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Changes of a material biointerface allow for specialized cell signaling and diverse biological responses. Biomaterials incorporating immobilized bioactive ligands have been widely introduced and used for tissue engineering and regenerative medicine applications in order to develop biomaterials with improved functionality. Furthermore, a variety of physical and chemical techniques have been utilized to improve biomaterial functionality, particularly at the material interface. At the interface level, the interactions between materials and cells are described. The importance of surface features in cell function is then examined, with new strategies for surface modification being highlighted in detail.

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Gold coated electrospun polymeric fibres as new electrode platform for glucose oxidase immobilization

Cited by 15 publications

References 59 publications

Fabrication of a Wearable Flexible Sweat pH Sensor Based on SERS-Active Au/TPU Electrospun Nanofibers

Fabrication of a Wearable Flexible Sweat pH Sensor Based on SERS-Active Au/TPU Electrospun Nanofibers

Electrospun nanofiber-based glucose sensors for glucose detection

Surface Functionalities of Polymers for Biomaterial Applications

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