Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Aljabali, Alaa A. A.; Al‐Trad, Bahaa; Gazo, Lina Al; Alomari, Ghada; Zoubi, Mazhar Salim Al; Alshaer, Walhan; Al‐Batayneh, Khalid; Kanan, Bahja; Pal, Kaushik; Tambuwala, Murtaza M.

doi:10.1016/j.molstruc.2021.130009

Cited by 18 publications

(13 citation statements)

References 46 publications

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“…In the DC, an inflammatory response plays a key role 7,12) . The diabetic heart exhibited a boosted level of cytokines, which can occur due to dysfunction of cardiac tissue and finally affect cardiac contractility 38,39) .…”

Section: Discussionmentioning

confidence: 99%

“…It is well documented that hyperglycemia causes oxidative stress, inflammation reaction via numerous mechanisms plays the crucial role in the expansion and progression of DC 10,11) . The activation of cyclooxygenase (COX) , glucose autoxidation, the generation of advanced glycation end products (AGE) , the polyol pathway, NADPH, and xanthine oxidase all play a part in the development of DC 1,6,12) . The above mechanisms boost the production of free radicals and inflammatory mediators, which further activate the stress signaling pathways 13) , that leading to enhanced the expression of NADPH oxidase, endothelin-1, Ang II, inflammatory cytokines and take part in boosting the NOS expression via activation of nuclear factor kappa B (NF-κB) , which boosts the production of nitric oxide (NO) .…”

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confidence: 99%

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Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway

Chen

Zhang

et al. 2022

J. Oleo Sci.

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IntroductionDiabetes mellitus (DM) has emerged as a global health issue that poses a risk to human health 1) . DM is a metabolic dysfunction that induces a defect in insulin action or insulin secretion from the pancreatic β-cells, which results in hyperglycemia with commotion of protein, carbohydrate and fat metabolism 2) . Due to disturbances in metabolism, DM leads to chronic complications include cardiomyopathy, nephropathy, retinopathy and neuropathy 3,4) . Among of them complications, cardiomyopathy (DC) enhances the risk of heart disease independently of underlying hypotension and coronary artery disease 1,5) .

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway

Chen

Zhang

et al. 2022

J. Oleo Sci.

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“…In another study, the anti-hyperglycemic activity of AuNPs in STZ-induced diabetic animal models has been estimated. It is observed that AuNPs cause a reduction in hyperglycemia, decreasing the protein tissue content of TGF-β1 and myocardial mRNA in diabetic cardiomyopathy animal model [42].…”

Section: Contribution Of Authors To the Nano-based Diabetes Therapymentioning

confidence: 99%

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

et al. 2021

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The occurrence of diabetes mellitus (DM) is increasing rapidly at an accelerating rate worldwide. The status of diabetes has changed over the last three generations; whereas before it was deemed a minor disease of older people but currently it is now one of the leading causes of morbidity and mortality among middle-aged and young people. High blood glucose-mediated functional loss, insulin sensitivity, and insulin deficiency lead to chronic disorders such as Type 1 and Type 2 DM. Traditional treatments of DM, such as insulin sensitization and insulin secretion cause undesirable side effects, leading to patient incompliance and lack of treatment. Nanotechnology in diabetes studies has encouraged the development of new modalities for measuring glucose and supplying insulin that hold the potential to improve the quality of life of diabetics. Other therapies, such as β-cells regeneration and gene therapy, in addition to insulin and oral hypoglycemic drugs, are currently used to control diabetes. The present review highlights the nanocarrier-based drug delivery systems and emerging treatment strategies of DM.

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“…Nanoparticles (NPs) are a novel technique used in the field of medical sciences which has been shown to have promising results [16]. Extensive researches have revealed the importance of NPs in medicine owing to their role in catalytic degradation [17], antiviral [18], antibacterial [19], anticancer [20], antidiabetic [21], and wound healing [22].…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used metals to synthesize NPs are platinum, palladium, silver, and gold [23]. Among these common metals, gold is possessing a high ionic conductivity, and synthesized gold nanoparticles (AuNPs) can be adjusted based on their surface state, shape, and size [18,21,[23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

Alhumaydhi

2022

Journal of Nanomaterials

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The synthesis of metal nanoparticles by using plant extracts is previously explored in phytomedicines. Nanobiotechnology has many applications, including cosmetic, packing, coating, biomedicine, and enhanced biological activity. Keeping in view the importance of Pistacia chinensis, its gold nanoparticles (AuNPs) have been synthesized by the eco-friendless and cost-effective method. In this study, the synthesized nanoparticles were characterized by advanced techniques such as UV-visible spectroscopy, Fourier transform infrared (FT-IR), and atomic force microscope (AFM) analysis. The biological activities of these synthesized nanoparticles were examined in vitro by measuring the enzymatic inhibition potential on urease and carbonic anhydrase and in vivo by determining the analgesic and sedative activities. The UV spectrum indicated various peaks at the range of 530-550 nm, showing nanoparticles formation. The FT-IR spectroscopy of the extracts and AuNPs indicated the presence of NH, C═N, and N═O in the extract involved in the nanoparticles synthesis. The size of nanoparticles was determined by AFM analysis. The AFM showed that the nanoparticles range from 10 to 100 nm and are almost spherical in shape. The synthesized AuNPs exhibited significant urease inhibition potential with an IC50 value of 44.98. Similarly, the nanoparticles exhibited good carbonic anhydrase inhibition with an IC50 value of 53.54 against acetazolamide having IC50 0.13. Pistacia chinensis extract and its AuNPs exhibited excellent attenuation p < 0.01 in acetic acid-induced writhing model at a dose of 15 mg/kg. The synthesized nanoparticles showed a significant sedative effect p < 0.001 compared to the standard drug. This research work has developed a green method to synthesize nanoparticles by using Pistacia chinensis extract and directed the researcher to purify active phytochemicals from Pistacia chinensis involved in nanoparticles synthesized.

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Gold Nanoparticles Ameliorate Diabetic Cardiomyopathy in Streptozotocin-Induced Diabetic Rats

Cited by 18 publications

References 46 publications

Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway

Cardioprotective Effect of <i>Gynostemma pentaphyllum</i> against Streptozotocin Induced Cardiac Toxicity in Rats via Alteration of AMPK/Nrf2/HO-1 Pathway

Emerging Treatment Strategies for Diabetes Mellitus and Associated Complications: An Update

Green Synthesis of Gold Nanoparticles Using Extract of Pistacia chinensis and Their In Vitro and In Vivo Biological Activities

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