Gold nanoparticles-based colorimetric investigation of triplex formation under weak alkalic pH environment with the aid of Ag+

Xiong, Chengdong; Wu, Chengke; Zhang, Hong; Ling, Liansheng

doi:10.1016/j.saa.2011.04.002

Cited by 17 publications

(13 citation statements)

References 39 publications

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“…[82] Here,A g + ions were used to stimulate the aggregation of Au NPs (Figure 13 A). [83] Au NPs were modified with the nucleic acid 58.Some of the capping nucleic acids were hybridized with 59,l eading to Au NPs modified with the single strand 58 and duplexes composed of 58/59.I nt he presence of Ag + ions,t he formation of the Ag + -bridged triplex 58/59/58 resulted in the aggregation of the Au NPs. Thea ggregation process was followed by absorption spectroscopy (Figure 13 B) and TEM imaging (Figure 13 C, panels Ia nd II).…”

Section: Reviewsmentioning

confidence: 99%

“…Aside from the pH‐stimulated formation of C + ⋅G‐C triplex DNA structures, the formation of Ag + ‐crosslinked C + ⋅G‐C triplex structures has been reported . Here, Ag + ions were used to stimulate the aggregation of Au NPs (Figure A) . Au NPs were modified with the nucleic acid 58 .…”

Section: Triplex‐based Assembly and Dissociation Of Nanostructuresmentioning

confidence: 99%

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Triplex DNA Nanostructures: From Basic Properties to Applications

et al. 2017

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Triplex nucleic acids have recently attracted interest as part of the rich "toolbox" of structures used to develop DNA-based nanostructures and materials. This Review addresses the use of DNA triplexes to assemble sensing platforms and molecular switches. Furthermore, the pH-induced, switchable assembly and dissociation of triplex-DNA-bridged nanostructures are presented. Specifically, the aggregation/deaggregation of nanoparticles, the reversible oligomerization of origami tiles and DNA circles, and the use of triplex DNA structures as functional units for the assembly of pH-responsive systems and materials are described. Examples include semiconductor-loaded DNA-stabilized microcapsules, DNA-functionalized dye-loaded metal-organic frameworks (MOFs), and the pH-induced release of the loads. Furthermore, the design of stimuli-responsive DNA-based hydrogels undergoing reversible pH-induced hydrogel-to-solution transitions using triplex nucleic acids is introduced, and the use of triplex DNA to assemble shape-memory hydrogels is discussed. An outlook for possible future applications of triplex nucleic acids is also provided.

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Section: Reviewsmentioning

confidence: 99%

Section: Triplex‐based Assembly and Dissociation Of Nanostructuresmentioning

confidence: 99%

Triplex DNA Nanostructures: From Basic Properties to Applications

et al. 2017

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“…38 This specific DNA conformation has been used for developing Au NP based sensing systems for DNA detection. 39,40 Target DNA hybridizes with two ssDNA probes to form a triplex DNA structure, causing the Au NP aggregation and the corresponding solution color change (Fig. 1b).…”

Section: Colorimetric Assaysmentioning

confidence: 99%

Gold nanoparticles as sensitive optical probes

Yuan

Chang

et al. 2016

Analyst

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Gold nanoparticles (Au NPs) have become one of the most popular materials for sensing of analytes of interest in the last decade, mainly because of their ease in preparation and conjugation, stability, biocompatibility, and size-dependent optical properties. We have witnessed many sensitive and selective Au NP based optical systems for the quantitation of metal ions, anions, proteins, and DNA, based on analyte induced changes in their absorption, fluorescence, and scattering. In this tutorial review, we briefly discuss wet chemical approaches for the preparation of Au NPs. Sensing mechanisms and strategies of Au NP based optical systems are provided to show basic concepts in designing sensitive and selective sensing systems. Strategies for signal amplification applied in Au NP based systems are emphasized for the analysis of trace amounts of analytes in real samples. Many excellent Au NP based optical sensing systems are discussed to highlight their practicality for the analysis of complicated biological and environmental samples. The tutorial review ends with the discussion of the challenges and future trends of Au NP based optical sensing systems.

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“…Cycling the pH led to the expansion and contraction of the nanoparticles which was observed as a change to the AuNP plasmon resonance peak from 524 to 533 nm, respectively. Interestingly, various groups have exploited such systems as a colorimetric assay for screening potential triplex-binding molecules ( 80 , 81 ). Such agents are of interest since they could be used to stabilize putative triplexes formed in genomic DNA that might modulate the expression of specific genes.…”

Section: Reconfigurable Structures Based On the Duplex-to-triplex Tramentioning

confidence: 99%

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology

Chandrasekaran¹,

Rusling

2017

Nucleic Acids Research

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DNA self-assembly has proved to be a useful bottom-up strategy for the construction of user-defined nanoscale objects, lattices and devices. The design of these structures has largely relied on exploiting simple base pairing rules and the formation of double-helical domains as secondary structural elements. However, other helical forms involving specific non-canonical base-base interactions have introduced a novel paradigm into the process of engineering with DNA. The most notable of these is a three-stranded complex generated by the binding of a third strand within the duplex major groove, generating a triple-helical (‘triplex’) structure. The sequence, structural and assembly requirements that differentiate triplexes from their duplex counterparts has allowed the design of nanostructures for both dynamic and/or structural purposes, as well as a means to target non-nucleic acid components to precise locations within a nanostructure scaffold. Here, we review the properties of triplexes that have proved useful in the engineering of DNA nanostructures, with an emphasis on applications that hitherto have not been possible by duplex formation alone.

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Gold nanoparticles-based colorimetric investigation of triplex formation under weak alkalic pH environment with the aid of Ag+

Cited by 17 publications

References 39 publications

Triplex DNA Nanostructures: From Basic Properties to Applications

Triplex DNA Nanostructures: From Basic Properties to Applications

Gold nanoparticles as sensitive optical probes

Triplex-forming oligonucleotides: a third strand for DNA nanotechnology

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