Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment

Wang, Chung Hao; Chang, Chia Wei; Peng, Ching An

doi:10.1007/s11051-010-0162-5

Cited by 55 publications

(29 citation statements)

References 30 publications

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“…The chitosan-coated gold nanorods were further modified with folic acid; this increased the specificity of internalization by human colon HT-29 cancer cells, which overexpress the folate receptor. Under 808-nm NIR laser illumination, the nanorods showed potential photothermal effects [69]. Guo et al indicated the limitations of the current PTT, which are applicable mostly at the primary site, but not to metastatic cancer.…”

Section: Effective Tumor Treatment Using Chitosan Nanoparticlesmentioning

confidence: 99%

Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy

Key

Park

2017

IJMS

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Current clinical methods for cancer diagnosis and therapy have limitations, although survival periods are increasing as medical technologies develop. In most cancer cases, patient survival is closely related to cancer stage. Late-stage cancer after metastasis is very challenging to cure because current surgical removal of cancer is not precise enough and significantly affects bystander normal tissues. Moreover, the subsequent chemotherapy and radiation therapy affect not only malignant tumors, but also healthy tissues. Nanotechnologies for cancer treatment have the clear objective of solving these issues. Nanoparticles have been developed to more accurately differentiate early-stage malignant tumors and to treat only the tumors while dramatically minimizing side effects. In this review, we focus on recent chitosan-based nanoparticles developed with the goal of accurate cancer imaging and effective treatment. Regarding imaging applications, we review optical and magnetic resonance cancer imaging in particular. Regarding cancer treatments, we review various therapeutic methods that use chitosan-based nanoparticles, including chemo-, gene, photothermal, photodynamic and magnetic therapies.

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Section: Effective Tumor Treatment Using Chitosan Nanoparticlesmentioning

confidence: 99%

Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy

Key

Park

2017

IJMS

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“…126 Biocompatible thiolated chitosan was used to stabilize GNRs in place of CTAB by Peng's group. 127 Moreover, GNRs functionalization with FA achieved site specific delivery to HT-29 colon cancer cells. HT-29 cells treated with FA-tagged GNRs irradiated with 808-nm NIR laser light at 2 W/cm 2 for 15 min showed complete cell death, while the NIH 3T3 cells without FA expression remained viable after NIR laser exposure.…”

Section: Gold Nanorodsmentioning

confidence: 99%

“…127 153 154 In the work of Baginskiy et al AuNSts were modified with chitosan to endow them Delivered by Publishing Technology to: SUNY Upstate Medical University IP: 93.113.178.150 On: Sun, 11 Oct 2015 13:29:50 Copyright: American Scientific Publishers…”

mentioning

confidence: 99%

Antitumor Therapy Using Nanomaterial-Mediated Thermolysis

Sawdon¹,

Weydemeyer²,

Peng³

2014

j biomed nanotechnol

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Nanomaterial-based systems present several novel therapeutic opportunities for cancer therapy based solely upon their unique physical and chemical properties. Despite advances in current cancer treatment, collateral damage to neighboring healthy tissues still cannot be avoided. By exploiting the strong optical and/or electromagnetic properties offered by nanomaterials, they are being employed as thermal nanoscalpels for the ablation of cancer cells. Through surface functionalization, these nanomaterials can be specifically targeted to tumorous tissue allowing for an increase in therapeutic potential and reduction in side effects. Moreover, these features provide nanomaterials with a tunable surface which can be used to modify optical, magnetic, thermal and mechanical properties. This review highlights carbon nanomaterials, nanogolds, magnetic nanoparticles and emerging hybrids applied for the thermolysis of cancer cells.

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“…In ligand exchange method, some biological molecules, such as phosphatidylcholine (PC) [16], lipids [17] and thiol compounds, such as alkanethiol [18], thiol-terminated poly (ethylene glycol) (PEG-SH) [19], thiolated chitosan [20], were used to replace CTAB completely or at least partially. The thiol group can form strong Au-S bond with gold surface.…”

Section: Surface Modifications Of Gnrsmentioning

confidence: 99%

Applications of gold nanorods in biomedical imaging and related fields

Hong-xing

Liu

et al. 2013

Chin. Sci. Bull.

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Gold nanorods (GNRs) have great potential widespread applications in biomedical imaging, drug delivery and photothermal therapy due to unique surface plasmon resonance (SPR) ranging from visible to near infrared (NIR) region, facile synthesis and easy functionalization. In this review, the recent progress of GNRs in bioimaging, drug delivery, photothermal therapy and theranostics is summarized and the recommendations for the future work on GNRs are also covered.

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Gold nanorod stabilized by thiolated chitosan as photothermal absorber for cancer cell treatment

Cited by 55 publications

References 30 publications

Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy

Multicomponent, Tumor-Homing Chitosan Nanoparticles for Cancer Imaging and Therapy

Antitumor Therapy Using Nanomaterial-Mediated Thermolysis

Applications of gold nanorods in biomedical imaging and related fields

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