Goldenhar anomaly in one of triplets derived from in vitro fertilization

Ferraris, Silvio; Silengo, Margherita; Ponzone, A; Perugini, L

doi:10.1002/(sici)1096-8628(19990521)84:2<167::aid-ajmg14>3.0.co;2-4

Cited by 16 publications

(10 citation statements)

References 5 publications

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“…GS has previously been observed in a few children born following ART. Roesch et al [2001] reported one child born following ICSI, and Ferraris et al [1999] and Yovich et al [1985] each reported one child born after IVF, both born in multiple births. In our study three children (Patients 1, 2, and 4) were the product of ART (Table II).…”

Section: Discussionmentioning

confidence: 99%

Oculo‐auriculo‐vertebral spectrum: Associated anomalies, functional deficits and possible developmental risk factors

Strömland

Miller

Sjögreen

et al. 2007

American J of Med Genetics Pt A

124

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Swedish patients with the oculo-auriculo-vertebral (OAV) spectrum participated in a prospective multidisciplinary investigation. The aims of the study were to describe their systemic and functional defects, especially autism spectrum disorders, and to search for possible etiologic risk factors. Available medical records were studied and the mothers answered a questionnaire on history of prenatal events. A clinical examination evaluating systemic findings, vision, hearing, speech, oral and swallowing function, and neuropsychiatric function, especially autism, was made. Eighteen patients, (11 males, 7 females) aged 8 months to 17 years with OAV were studied. Most frequent systemic malformations included, ear abnormalities (100%), ocular malformations (72%), vertebral deformities (67%), cerebral anomalies (50%), and congenital heart defects (33%). Functional defects consisted of hearing impairment (83%), visual impairment (28%), both visual and hearing impairment (28%), difficulties in feeding/eating (50%), speech (53%), mental retardation (39%), and severe autistic symptoms (11%). Three children were born following assisted fertilization (two intracytoplasmatic sperm injection, one in vitro fertilization), two mothers reported early bleedings, and six (33%) mothers had smoked during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Oculo‐auriculo‐vertebral spectrum: Associated anomalies, functional deficits and possible developmental risk factors

Strömland

Miller

Sjögreen

et al. 2007

American J of Med Genetics Pt A

124

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“…It has been shown that the malformation rate in children conceived by IVF‐ET does not differ from that of the general population 9 . Poland anomaly, 10 DiGeorge syndrome 11 and Goldenhar syndrome 12 after in vitro fertilization have been reported. Our patient appears to be the first case of Treacher− Collins syndrome after IVF‐ET.…”

Section: Discussionmentioning

confidence: 99%

Co‐occurrence of Down syndrome and Treacher−Collins syndrome

Sonoda¹,

Sawada²,

Kouno

et al. 2002

Pediatrics International

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“…One twin in the ICSI group had Goldenhar syndrome, a rare disorder; his twin brother was healthy. The cause of Goldenhar syndrome is unclear but the disorder has been previously reported in one ICSI child (Roesch et al 2001) and two IVF children (Yovich et al 1985; Ferraris et al 1999) born after multiple births. Children born after IVF have also been reported to be at increased risk of cerebral palsy (Strömberg et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Ophthalmological findings in children born after intracytoplasmic sperm injection

Wikstrand

Strömland

Flodin

et al. 2005

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI) and compare them with visual function and ocular morphology in matched children born after spontaneous conception. Methods: A total of 137 children born after ICSI and 159 control children were examined at the age of 5 years in a blinded study. The two groups were matched for age, gender and maternal age. The children underwent a detailed ophthalmological investigation by an ophthalmologist and an orthoptist. Results: A total of 90.4% of the ICSI children had a visual acuity (VA) in the better eye of ‡ 0.8, compared with 93.7% of the controls (NS). No significant differences were found between ICSI children and controls with regard to hyperopia, myopia, astigmatism, heterotropia, stereoscopic vision and convergence. One child with Goldenhar syndrome and one with Marcus Gunn syndrome were observed in the ICSI group. One child in the ICSI group was treated for retinopathy of prematurity. Conclusion: In this limited study group, no significant differences in visual function and/or ocular morphology were found between children born after ICSI and matched control children at the age of 5 years.

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Goldenhar anomaly in one of triplets derived from in vitro fertilization

Abstract: Fig. 1. Patient phenotype showing hemifacial microsomia and skin tags on the scalp.

Cited by 16 publications

References 5 publications

Oculo‐auriculo‐vertebral spectrum: Associated anomalies, functional deficits and possible developmental risk factors

Oculo‐auriculo‐vertebral spectrum: Associated anomalies, functional deficits and possible developmental risk factors

Co‐occurrence of Down syndrome and Treacher−Collins syndrome

Ophthalmological findings in children born after intracytoplasmic sperm injection

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