Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

Erfle, Peer; Riewe, Juliane; Bunjes, Heike; Dietzel, Andreas

doi:10.1039/d1lc00047k

Cited by 19 publications

(16 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared to our previous work, 54 the HLM system offers the possibility of using higher lipid concentrations while achieving smaller particle sizes and more narrow size distributions. Calculating the production efficiency of the HLM system in the form of lipid processing per hour with the consideration that the PDI should be below 0.07 for monodisperse spherical particles and assuming that all lipid precipitates as nanodroplets with a size below 200 nm, this new mixer can process 48 mg h −1 (ESI: † Table S5).…”

Section: Resultsmentioning

confidence: 90%

“…The coaxial lamination mixer (CLM) in the previous work 54 allowed fouling-free precipitation at flow rates not exceeding 200 μl min −1 . This limited the throughput of the system.…”

Section: Design Of the Horseshoe Lamination Mixersmentioning

confidence: 99%

“…2a) providing protection against particles that can cause clogging of the system. 54 The channel initially has a round cross-sectional shape with an inner diameter of 200 μm and changes into a rectangular shape after 1 mm. Two systems, A (ESI: † system A view) and B (ESI: † system B view), were designed with slightly different flow focusing sections.…”

Section: Design Of the Horseshoe Lamination Mixersmentioning

confidence: 99%

“…Previous work proved shortterm stability of comparable nanodispersions. 34,54 Thus, agglomerates may have formed during sample preparation. Cryo-TEM, which uses a different sample preparation technique, could be helpful to clarify whether such nanodispersions contain agglomerates or not.…”

Section: Electron Microscopic Evaluation Of Cryo-stabilized Nanodispe...mentioning

confidence: 99%

“…53 We recently reported on a coaxial lamination mixer (CLM) with channel geometries preventing material-wall interactions while ensuring efficient and fast mixing. 54 This unique micromixer, fabricated using two-photon polymerization (2PP), includes inlet filters, a nozzle for coaxial injection, and a series of coaxial lamination elements that increase the interfacial area and reduce the layer thickness of the organic phase. Nanodispersions with castor oil and the hard fat Softisan® 100 with particle sizes between 56 nm and 115 nm and polydispersity indices between 0.04 and 0.12 can be prepared with the CLM system.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 90%

“…The coaxial lamination mixer (CLM) in the previous work 54 allowed fouling-free precipitation at flow rates not exceeding 200 μl min −1 . This limited the throughput of the system.…”

Section: Design Of the Horseshoe Lamination Mixersmentioning

confidence: 99%

Section: Design Of the Horseshoe Lamination Mixersmentioning

confidence: 99%

Section: Electron Microscopic Evaluation Of Cryo-stabilized Nanodispe...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Mainik,

Spiegel,

Blasco

2023

Advanced Materials

View full text Add to dashboard Cite

Since the pioneering work of Kawata and colleagues in 1997, multi‐photon 3D laser printing, also known as direct laser writing, has made significant advancements in a wide range of fields. Moreover, the development and commercialization of photocurable inks for this technique have expanded rapidly. One of the current trends is the transition from static to active printable materials, often referred to as 4D microprinting, which enables a new degree of control in the printed systems. This review focuses on four primary application areas: microrobotics, optics and photonics, microfluidics, and life sciences, highlighting recent progress and the crucial role of active materials, including liquid crystalline elastomers, hydrogels, shape memory polymers, and composites, among others. It also addresses ongoing challenges and provides insights into the future prospects in the different fields.

show abstract

Cavitation behavior and mixing performance of antisolvent precipitation process in an ultrasonic micromixer

et al. 2023

View full text Add to dashboard Cite

A facile and robust ultrasonic micromixer was developed to intensify antisolvent precipitation via ultrasonic cavitation. The gas supersaturation created from solventantisolvent mixing was found to be a novel driving force which facilitated the generation of cavitation bubbles (CBs). Instead of being attached on the channel wall, numerous CBs translated across the microchannel at a speed up to 1.7 m/s, inducing intense transverse flow over the cross-section. The unique cavitation behavior enabled rapid mixing (mixing time 15-45 ms at 30 W) of solvent-antisolvent over wide Reynolds number range (70-500) and flow rate ratio (5:1-2:3), providing better operability for antisolvent precipitation. The effects of ultrasonic power, total flow rate, flow rate ratio, and solvent on cavitation behavior and mixing performance were quantitatively studied. Finally, the potential of the ultrasonic micromixer as a new tool for antisolvent precipitation was demonstrated by synthesizing size-controllable and monodisperse polymeric nanoparticles in a high-throughput and reproducible manner.

show abstract

Goodbye fouling: a unique coaxial lamination mixer (CLM) enabled by two-photon polymerization for the stable production of monodisperse drug carrier nanoparticles

Abstract: Poorly soluble drugs can be incorporated in lipid carrier nanoparticles to achieve sufficient bioavailability and open up diverse routes of administration. Preparation by antisolvent precipitation in microfluidic systems enables excellent...

Cited by 19 publications

References 52 publications

Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles

Horseshoe lamination mixer (HLM) sets new standards in the production of monodisperse lipid nanoparticles

Recent Advances in Multi‐Photon 3D Laser Printing: Active Materials and Applications

Cavitation behavior and mixing performance of antisolvent precipitation process in an ultrasonic micromixer

Contact Info

Product

Resources

About