Grafting of poly(methacrylic acid-co-acrylamide) film on silicon surface via a simultaneous hydrolysis process

Liu, Yang; Han, Yutong; Wu, Yunwen; Xiong, Lishuang; Hang, Tao; Ling, Huiqin; Hu, Anmin; Gao, Liming

doi:10.1016/j.mtcomm.2019.100678

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…In Figure (b), the core-level N 1s behavior is depicted with the divided components of N–H (401.27 eV), N–O (402.62 eV), and N–H 2 (400.19 eV) corresponding to MIP immobilized with the serotonin template. The assigned N–H and N–H 2 components at 401.27 and 400.19 eV, respectively, were found to have originated from our targeted biomolecule 5-HT, whereas the assigned N–O (402.62 eV) along with the N–H (401.27 eV) peak had its source in the AM monomer present in our synthesized polymer. , However, in Figure (c), the N 1s spectrum exhibits two peaks of N–H and N–O along with the emergence of a novel feature N*, which proves the removal of the template molecule 5-HT from the MIP structure. The occurrence of the above feature (marked with *) evidenced at low binding energy is most likely to happen due to the deprotonation of the few N–H bonds.…”

Section: Resultsmentioning

confidence: 76%

Molecularly Imprinted Polymer Interface on Screen-Printed ZnO Nanorod Field Effect Transistors for Serotonin Detection in Clinical Samples

Sinha,

Chakraborty,

Ahmed

et al. 2023

ACS Biomater. Sci. Eng.

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Ultrasensitive detection of serotonin is crucial for the early diagnosis of several diseases like Parkinson’s and Alzheimer’s. Most of the existing detection strategies are still not suitable for sensitive point-of-care applications. This study presents direct molecular imprinting of serotonin on the surface of three-dimensional zinc oxide (ZnO) nanorod devices connected in a field effect transistor (FET) configuration to achieve ultrasensitive, real-time, and rapid detection with a convenient and affordable approach, which has significant potential for translation to clinical settings. This strategy has enabled pushing the detection limit to 0.1 fM in a physiological analyte in real time with screen-printed electrodes, thereby resulting in the convenient batch fabrication of sensors for clinical validation. The response of the sensor with the clinical sample has been correlated with that of the gold standard and has been observed to be statistically similar.

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Section: Resultsmentioning

confidence: 76%

Molecularly Imprinted Polymer Interface on Screen-Printed ZnO Nanorod Field Effect Transistors for Serotonin Detection in Clinical Samples

Sinha,

Chakraborty,

Ahmed

et al. 2023

ACS Biomater. Sci. Eng.

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“…The use of gamma rays as an energy source is a less harmful, less toxic, and more sustainable option for the planet because the preparation, reaction time, and chemical waste are reduced [24]. Therefore, producing high-quality and pure materials is of utmost importance to meet the worldwide demand for disposables and biomedical devices [25].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Functionalization of Silicone-graft-poly(N-vinylimidazole) Catheters

Navarrete-Germán,

Gómez-Lázaro,

López-Saucedo

et al. 2024

Molecules

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In this work, we present the modification of a medical-grade silicone catheter with the N-vinylimidazole monomer using the grafting-from method at room temperature and induced by gamma rays. The catheters were modified by varying the monomer concentration (20–100 vol%) and the irradiation dose (20–100 kGy). Unlike the pristine material, the grafted poly(N-vinylimidazole) chains provided the catheter with hydrophilicity and pH response. This change allowed for the functionalization of the catheters to endow it with antimicrobial features. Thus, the quaternization of amines with iodomethane and bromoethane was performed, as well as the immobilization of silver and ampicillin. The inhibitory capacity of these materials, functionalized with antimicrobial agents, was challenged against Escherichia coli and Staphylococcus aureus strains, showing variable results, where loaded ampicillin was amply better at eliminating bacteria.

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“…The following study focuses on the grafting of bioactive polymers bearing carboxylate groups such as polyacrylic acid (PAAc) and methacrylic acid (PMAc) and their chemical and mechanical characterizations. These compounds are chosen as non-toxic, biocompatible and hydrophilic polymers [10,[36][37][38][39][40][41][42]. These bioactive polymers are also very reactive [43], they have the ability to form strong bonds with various materials and are also used as surgical adhesives [44].…”

Section: Introductionmentioning

confidence: 99%

Simple UV-Grafting of PolyAcrylic and PolyMethacrylic Acid on Silicone Breast Implant Surfaces: Chemical and Mechanical Characterizations

Wozniak,

Humblot,

Vayron

et al. 2023

Coatings

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Poly(dimethyl siloxane) (PDMS) is one of the most widely used materials in the biomedical field. Despite its numerous advantages, its hydrophobic character promotes bacterial adhesion and biofilm formation. For breast implants, biocompatibility is challenged due to the biofilm formed around the implant that can degenerate to severe capsular contracture over time. Thus, the laboratory has set up strategies to prevent bacterial contamination by grafting covalently hydrophilic bioactive polymers on the surface of implants. In this study, poly(methacrylic acid) (PMAc) and poly(acrylic acid) (PAAc) were chosen as non-toxic and biocompatible bioactive polymers known for reducing bacteria adhesion. These polymers are also good candidates to lend reactivity on the surface for further functionalization. X-ray photoelectron Spectroscopy (XPS) and Fourier-Transform Infrared spectroscopy (FTIR) analysis have highlighted the covalent grafting of these polymers. Apparent water contact angle measurements have shown the change in hydrophilicity on the surface, and a colorimetric assay allowed us to assess the grafting rate of PMAc and PAAc. Tensile strength assays were performed to ensure that the functionalization process does not significantly alter the material’s mechanical properties. Analyses of the surface aspect and roughness by Scanning Electron Microscope (SEM) and optical profilometer allow us to formulate hypotheses to approach the understanding of the behavior of the polymer once grafted.

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Grafting of poly(methacrylic acid-co-acrylamide) film on silicon surface via a simultaneous hydrolysis process

Cited by 4 publications

References 53 publications

Molecularly Imprinted Polymer Interface on Screen-Printed ZnO Nanorod Field Effect Transistors for Serotonin Detection in Clinical Samples

Molecularly Imprinted Polymer Interface on Screen-Printed ZnO Nanorod Field Effect Transistors for Serotonin Detection in Clinical Samples

Antimicrobial Functionalization of Silicone-graft-poly(N-vinylimidazole) Catheters

Simple UV-Grafting of PolyAcrylic and PolyMethacrylic Acid on Silicone Breast Implant Surfaces: Chemical and Mechanical Characterizations

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