Reproductive function is the cornerstone in achieving better profitability for sheep; researchers have developed several ways to guide the reproduction of ewes and develop their reproductive efficiency by its needs. This contributed to reducing the vaccination season and the timing of births in ewes during a limited year to provide optimal care conditions. The optimal use of these techniques in the reproductive function enables us to enter estrus, increase the ovulation rate, and the appropriate timing of artificial insemination, which in turn increases the reproductive efficiency of ewes. Therefore, it has become necessary to use modern biotechnologies such as estrus synchronization technology, which is one of the technologies that help reduce the time and effort required to detect estrus by collecting estrus cases in treated animals. By applying reproductive care programs such as synchronizing estrus and increasing fertility using compounds such as injections of human chorionic gonadotropin, gonadotropin-releasing hormone or progesterone after mating and prostaglandin F2alpha, prostaglandin E and melatonin hormone, it may help to be performed at a specific time