Serum Amyloid A as a Promising Biomarker in Domestic Animals’ Reproduction: Current Knowledge and Future Perspective

Bazzano, Marilena; Marchegiani, Andrea; Troisi, Alessandro; McLean, Amy; Laus, Fulvio

doi:10.3390/ani12050589

Cited by 9 publications

(10 citation statements)

References 78 publications

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“…APPs are species specific and their diagnostic importance varies according to animal species [13,14]. APPs whose levels change in the case of infection and inflammation are accepted as a nonspecific indicator of the tissue damage [3,15]. In general, APPs, which can directly destroy inflammatory agents, also contribute to the tissue healing and regeneration.…”

Section: Acute Phase Proteinsmentioning

confidence: 99%

Clinical Significance of Some Acute Phase Proteins in Cattle

Bozukluhan¹,

Merhan²

2023

Veterinary Medicine and Science

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Acute phase proteins are proteins synthesized by the liver in response to the acute phase response. While these proteins are insignificant in healthy animals, their concentrations increase rapidly during infection, inflammation, or tissue damage and are used as an indicator of inflammation. Since the blood concentrations and importance levels of these clinically important proteins differ according to the animal species, they are evaluated separately for each animal species. Most of the acute phase proteins have been studied in detail in the field of human medicine and are routinely used in the diagnosis and prognosis of diseases. In the field of veterinary medicine, it has not been used sufficiently. In this book chapter, we will provide up-to-date information about acute phase proteins that are important for cattle, as well as explain that acute phase proteins can be used in the early diagnosis of diseases, in the differentiation of viral and bacterial infections, in guiding the treatment of sick animals and in determining their prognosis.

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Section: Acute Phase Proteinsmentioning

confidence: 99%

Clinical Significance of Some Acute Phase Proteins in Cattle

Bozukluhan¹,

Merhan²

2023

Veterinary Medicine and Science

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“…The production of these proteins is enhanced during infection or the stage of inflammation. It includes CRP, alpha-1 antitrypsin, mannosebinding protein, D-dimer protein, alpha-1 anti-chymotrypsin, alpha 2 macroglobulin, complement factors, prothrombin, factor VIII, fibrinogen, von-Willebrand factor, SAA, SAP complement, plasminogen, ceruloplasmin (Cp), complement factors, and haptoglobin (Hp) (Eckersall and Bell 2010;Bazzano et al 2022).…”

Section: Positive Acute Phase Proteinsmentioning

confidence: 99%

“…The production of these proteins is decreased, so they are called as negative acute phase proteins. Negative APPs include transferring, transthyretin, retinol binding protein, transcortin and albumin (Eckersall and Bell 2010;Bazzano et al 2022).…”

Section: Negative Acute Phase Proteinsmentioning

confidence: 99%

“…The detection of these APPs makes the detection easy and feasible because they can be easily detected from milk and there is no need for blood collection. If inflammation is present in the udder and milk APPs are increased due to this inflammation than they are regarded as sensitive and more reliable biomarker, then the somatic cell count (Ahmed et al 2021;Gulshan et al 2021;Bazzano et al 2022).…”

Section: Role Of Acute Phase Proteins In Mastitismentioning

confidence: 99%

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Acute Phase Proteins as Biomarkers in Perspective to Animal Diseases Diagnosis

2022

Agrobiol. Rec.

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When an infection, trauma or inflammation occurs due to any reason or disease, it causes acute phase response. A lot of pathophysiological responses occur due to it including pyrexia, pain, leukocytosis, removal of pathogen or causative agent to minimizing the tissue damage and increasing tissue repairing process. Acute phase proteins (APPs) are produced by hepatic or extrahepatic sources. Liver production of acute hepatic protein is regulated by pro-inflammatory cytokines. Liver produces positive and negative, both types of APPs. The acute phase protein that plays significant role in the activation of almost whole inflammation process and tissue recovery, starting from activation of complement system, binding cellular components, eliminating free radicles, neutralizing enzymes and controlling immune response are positive. APPs also play significant role in the diagnosis of different animals' diseases like bovine viral diarrhea, tuberculosis, bovine respiratory syncytial virus, mastitis, etc. These diseases are otherwise difficult to diagnose. Thus, APPs play a biomarker role in the early detection of chronic diseases. In this way, it become easy to diagnose and treat these diseases.

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“…Wojtysiak and collaborators provided insights into post-breeding-induced endometritis in the mare, by determining the secretion of anti-inflammatory cytokines and acute-phase proteins in the uterus before and after artificial insemination [ 7 ]. As academic editors, we aimed to deepen the knowledge and use of acute phase proteins in daily practice, offering a review article on serum amyloid A [ 8 ]. This protein has been widely investigated in pets and food-producing animals as a possible indicator of inflammatory and infective conditions, especially in the field of animal reproduction.…”

mentioning

confidence: 99%