Granular Cell Ameloblastoma of the Mandible with Metastasis to the Third Thoracic Vertebra

Takahashi, Keiichi; Kitajima, Tadashi; M, Lee; Iwasaki, Nao; Inoue, Seijiro; Matsui, Noriko; Ohki, Kohji; Nagao, Katsuhito; Akikusa, Bunshirou; Matsuzaki, Osamu

doi:10.1097/00003086-198507000-00021

Cited by 18 publications

(12 citation statements)

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“…They are rarely considered to exhibit metastatic spread 22 . Nevertheless, case reports of metastatic disease has led authors including Elzay and Slootweg and Muller to coin the terms metastatic ameloblastoma and ameloblastic carcinoma 23–28 . Metastatic ameloblastoma refers to lesions that metastasize despite having the typical benign histology of ameloblastoma in both the primary and metastatic lesions.…”

Section: Discussionmentioning

confidence: 99%

Mandibular ameloblastoma: clinical experience and literature review

Sham¹,

Leong²,

Maher³

et al. 2009

ANZ Journal of Surgery

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Section: Discussionmentioning

confidence: 99%

Mandibular ameloblastoma: clinical experience and literature review

Sham¹,

Leong²,

Maher³

et al. 2009

ANZ Journal of Surgery

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“…The tumor seems to enhance uniformly after contrast administration 3,5 . However, these types of changes can be seen in other spinal canal tumors, including schwannoma, meningioma, paraganglioma, ependymoma, or metastatic tumor 11–18 . While there may be some subtle differences between the tumors radiographically, tissue diagnosis is required to be definitive.…”

Section: Discussionmentioning

confidence: 99%

Intradural, extramedullary spinal cord granular cell tumor: A case report and clinicopathologic review of the literature

Weinstein

Arora

Thompson³

2010

Neuropathology

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Granular cell tumor (GCT) of the spine is uncommon, with intradural extramedullary location being exceptionally rare. The non-specific clinical presentation and variable histologic patterns can make recognition of this tumor challenging. Two previous reports of GCT of the spine were reviewed (Medline 1960-2009) and analyzed with respect to this case report. The patients included two women and one man (mean age, 28.7 years). Patients presented with 3 to 4 months of lower back pain and/or lower extremity radiculopathy. The lesions appeared radiographically to be intradural and extramedullary or intramedullary. The tumors were found at T10 or L1-L2 space. Radiographically, all tumors enhanced homogenously on T1 post-gadolinium imaging with a mean tumor size of approximately 1.6 cm. Histologically, the tumors were composed of large, polygonal granular cells. The abundant cytoplasm was fine or coarsely granular, surrounding small, pale-staining nuclei, which were eccentrically located in the cell. The tumor cells were periodic acid Schiff positive, diastase resistant, and were positive with S-100 protein, CD68, inhibin, and neuron-specific enolase immunohistochemistry. The clinical and histologic differential diagnosis includes schwannoma, neurofibroma, meningioma, astrocytoma, melanocytoma, and metastatic tumors. Patients were managed with excision. One patient had symptomatic and radiographic local recurrence that was subsequently treated with radiation, resulting in stabilization of disease and symptoms. Intradural GCTs of the spine are rare and radiographically indistinguishable from tumors that more commonly arise in this location. Histologic recognition of this rare tumor is important because the subsequent clinical course of the disease differs from other similar lesions.

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“…None of the AGC cases reported here were metastatic; however, a few cases have been previously reported. When spreading occurred it mostly moved to the cervical lymph nodes, the lungs, the thorax or to the neck 17 - 20. These cases presented a long duration from the time of diagnosis to the end of treatment, ranging from 18 to 45 years.…”

Section: Discussionmentioning

confidence: 99%

Ameloblastoma with distinctive granular cell pattern: An 8case study

et al. 2018

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Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87.5% of cases occurred in non-Caucasians, with a slight gender predilection for men (62.5%). There was no evidence of recurrence, and the majority of the cases were treated with surgical resection (87.5%). All tumors displayed histopathological features consistent with the diagnosis of ameloblastoma with granular cell pattern.

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Granular Cell Ameloblastoma of the Mandible with Metastasis to the Third Thoracic Vertebra

Cited by 18 publications

References 0 publications

Mandibular ameloblastoma: clinical experience and literature review

Mandibular ameloblastoma: clinical experience and literature review

Intradural, extramedullary spinal cord granular cell tumor: A case report and clinicopathologic review of the literature

Ameloblastoma with distinctive granular cell pattern: An 8case study

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