Granular cell tumors of the vulva

Horowitz, Ira; Copas, Pleas; Majmudar, Bhagirath

doi:10.1016/0002-9378(95)90414-x

Cited by 47 publications

(40 citation statements)

References 18 publications

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“…El diagnóstico diferencial incluye lesiones quísticas benignas, quistes sebáceos, fibroma, lipoma, papiloma, hidradenoma, quiste epidérmico, quiste de Bartholino y melanoma 3 . Histológicamente, se debe realizar diagnóstico diferencial con un carcinoma de células escamosas por la presencia de hiperplasia pseudocarcinomatosa en la epidermis subyacente en las formas subepiteliales (presente en casi el 50 % de los casos) 8 . El tratamiento del tumor de células granulares es la exéresis quirúrgica de la lesión, con márgenes de seguridad, al menos 1-2 cm libres para evitar la recurrencia (menor en formas nodulares) 4,8 .…”

Section: Discussionunclassified

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Tumor de células granulares de la vulva: caso clínico

Campo

Herrera

Ros

et al. 2017

Rev. chil. obstet. ginecol.

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RESUMENEl tumor de células granulares es una neoplasia de la piel y los tejidos blandos muy poco frecuente, benigna y de crecimiento lento, pero con altas tasa de recurrencia. La localización más frecuente en el aparato genital es en la vulva. Se debe realizar diagnóstico diferencial con otras lesiones vulvares, debido al manejo distinto de esta tumoración. El diagnóstico generalmente es histológico, ya que clínicamente es muy difícil diferenciarlo de otras tumoraciones a nivel vulvar. El tratamiento recomendado es la exéresis quirúrgica, con márgenes de seguridad. En caso de bordes afectos, se recomienda realizar una reescisión, por la frecuencia de recurrencia local y porque ésta puede ser el primer indicador de una conducta agresiva. Presentamos un caso clínico a nivel vulvar, con el objetivo de destacar la importancia de realizar un diagnóstico correcto, para un buen manejo clínico y seguimiento. Las formas malignas suponen menos del 3% de estos tumores y son muy agresivas PALABRAS CLAVE: tumor células granulosa, tumor vulva, lesión benigna vulvar ABSTRACTThe granular cell tumor is a neoplasm of the skin and soft tissue very rare, benign and slow growing, but with high recurrence rate. The most frequent location in the genital tract is in the vulva. Differential diagnosis should be made with other vulvar lesions, due to differences in the management of this tumor. The diagnosis is usually histological, since it is clinically difficult to differentiate it from other tumors at the vulvar level. The recommended treatment is surgical excision, with safety margins. In case of affected borders, it is recommended to perform a resection, due to the local recurrence and this may be the first indicator of aggressive behavior. We present a clinical case at the vulvar level, in order to emphasize the importance of making a correct diagnosis, for a good clinical management and follow-up. Malignant forms account for less than 3% of these tumors and are very aggressive.

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Section: Discussionunclassified

“…La diseminación puede ser por vía linfática o hematógena. Durante el seguimiento, debe realizarse una exploración completa, ya que podemos encontrar metástasis a distancia después de una primera lesión vulvar 8 . No responden a radiación o quimioterapia y el tratamiento es quirúrgico con escisión local amplia con linfadenectomía 7 .…”

Section: Discussionunclassified

Tumor de células granulares de la vulva: caso clínico

Campo

Herrera

Ros

et al. 2017

Rev. chil. obstet. ginecol.

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“…The use of 19 different descriptive synonyms attests to the uncertainty regarding its nature [3]; some of which include granular cell myoblastoma, granular cell schwannoma, and granular cell tumor [1,7]. Various cell types have been implicated in the histogenesis of GCT including skeletal and smooth muscle cells, fibroblasts, and histiocytes [1,7].…”

Section: Discussionmentioning

confidence: 99%

Granular cell tumor (Abrikossoff's tumor) of the labium majus: a case report

Yaghoobi¹,

Jazayeri²,

Alamshahi³

et al. 2016

Glob Dermatol

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Granular Cell Tumor (GCT) is an uncommon, benign tumor of neural origin resembling Schwann cells. It is more common in females and blacks. Head and neck regions are the most sites involved by the tumor, but it can occur in any part of the body. Vulva, ovary and cervix in females and scrotum in males can present GCT. The importance of this tumor is potential malignant transformation in rarity. Total excision is the choice treatment for GCT because of probability of recurrences.In this article, we described a case of granular cell tumor of the labium majus in a 21-year old lady, from southwest of Iran. Subsequent investigations confirmed positive results for S100 protein and neuron specific enolase, but Periodic Acid Schiff (PAS) staining was negative.Our findings confirmed neural origin for GCT.

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“…[1,2] Bu tümörler, ilk olarak 1854 yı-lında Weber tarafından, 1926 yılında da Abrikossof tarafından tanımlanmıştır. [3,4] Genellikle benign karakter göstermekle birlikte %1-3 olguda malign olarak tanımlanmaktadır.…”

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“…[5] Bu tümör her yaşta görülmekle birlikte en sık 4-6. dekadlarda rastlanmakta ve kadınlarda iki kat daha fazla göz-lenmektedir. [2] Tümörün histolojik olarak tipik özelliği yüzeyel psödoepitelyomatöz hiperplazi göstermesidir. Bu nedenle epidermoid hücreli karsinom ile ayırıcı tanı zorluğu yaşanabilmekte-dir.…”

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A rare granular cell tumor of the vulva: a case report

KAPLAN¹

2015

TJ Oncol

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Granular cell tumors are rare tumors, usually located subcutanesously or intramucosal. Most frequent presentation is in the head and neck region especially in the tongue, 5-15% of the cases are vulvar. Originating from Scwhan cells, these tumors are usually benign and only 1-3% of the cases have malign behaviour. As these tumors have an agressive course and do not respond to chemo-radiation, to mention the importance of early diagnosis we present this case. Granüler hücreli tümörler, sıklıkla subkutan dokuda veya mukozada yerleşim gösterir ve nadir görülür. En sık baş-boyun bölgesinde ve dilde yerleşimlidir, %5-15 oranında vulvada görülür. Schwan hücrelerinden köken aldığı bilinen bu tü-mörler, genellikle benign olup %1-3 oranda malign davranış gösterirler. Malign granüler hücreli tümörlerin agresif seyirli olması ve kemoterapi-radyoterapiye cevap vermemesi nedeni ile erken tanının önemini vurgulamak için bu olgu sunuldu.

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Granular cell tumors of the vulva

Cited by 47 publications

References 18 publications

Tumor de células granulares de la vulva: caso clínico

Tumor de células granulares de la vulva: caso clínico

Granular cell tumor (Abrikossoff's tumor) of the labium majus: a case report

A rare granular cell tumor of the vulva: a case report

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