Granulocytic sarcoma (chloroma): CT manifestations.

Pomeranz, Stephen J.; Hawkins, H H; Towbin, Richard B.; Lisberg, W N; Clark, R A

doi:10.1148/radiology.155.1.3856292

Cited by 58 publications

(21 citation statements)

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“…As in our case, they also rarely occur preceding any clinical or other radiographic evidence of leukemia [5]. They may also occur after a remission has been achieved [6,7].…”

Section: Discussionsupporting

confidence: 49%

Solitary myeloblastoma presenting as acute hydrocephalus: review of literature, implications for therapy

1988

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An unusual presentation of a case of myeloblastoma (granulocystic sarcoma, chloroma) as demonstrated by computed tomography (CT) and selective angiography is reported. Our patient, who presented with acute hydrocephalus due to a large posterior fossa myeloblastoma, had no evidence of systemic disease in either peripheral blood smear, bone marrow aspiration, lumbar puncture or further metastatic workup. While no evidence for generalized disease was seen, systemic chemotherapy may help to prevent overt systemic leukemia.

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“…As in our case, they also rarely occur preceding any clinical or other radiographic evidence of leukemia [5]. They may also occur after a remission has been achieved [6,7].…”

Section: Discussionsupporting

confidence: 49%

Solitary myeloblastoma presenting as acute hydrocephalus: review of literature, implications for therapy

1988

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“…The etiology for brain and spinal sarcomas remains unknown. Various possible etiologies are raised in the literature, such as previous external beam radiation therapy delivered to various scalp pathologies, to brain primary or secondary neoplasms, and to organs in the vicinity of the CNS [3, 8, 9, 10, 11, 12]. The incidence of radiation-induced sarcomas of the brain or spine seems to be similar to sarcomas occurring elsewhere in the body, 5–15 years following radiation therapy, within radiation fields [6].…”

Section: Discussionmentioning

confidence: 99%

Primary Sarcomas of the Central Nervous System

et al. 2000

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The medical files of 14 patients with primary brain and spine sarcomas were retrospectively reviewed. Ten patients had primary brain sarcomas and 4 primary spinal sarcomas. The tumors probably originated in the brain substance or blood vessels, in the meninges or in the inner aspect of the skull. The spinal tumors originated in the nerve roots of the cauda equina and in the spinal substance or blood vessels. The most common type was angiosarcoma. Removal of the brain tumors was performed in 95% of the patients. Radiotherapy was delivered to 6 patients with brain sarcomas and to all patients with primary spinal sarcomas. Metastatic disease to the lung or pleural effusion was evident in 2 patients who underwent total removal of their tumors followed by radiation therapy.

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“…In some cases GS occur up to 2 years before AML is diagnosed [39, 40]. Very often, GS are mistaken for malignant lymphoma [41, 42, 43, 44]. This may be due to the fact that the granulation of myeloid blasts is not obvious in histological sections.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Granulocytic Sarcoma by Fine-Needle Aspiration Cytology

Bangerter¹,

Hildebrand²,

Waidmann³

et al. 2000

Acta Haematol

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Granulocytic sarcoma (GS) occurs in patients with chronic myeloproliferative disorders as well as in patients with acute myeloid leukemia (AML). These tumorous masses can occur anywhere in the body and have to be differentiated from lymphoma, carcinoma or infectious processes. We report the results of fine-needle aspiration cytology (FNAC) in 26 patients with GS. Seventeen patients suffered from AML and 9 from chronic myeloid leukemia (CML) blast crisis. In 5 patients with AML, GS was the initial presentation of hematological malignancy, in the remaining 21 patients, FNAC confirmed relapse of AML or extramedullary blast crisis of CML. In 8 patients, GS was located in the skin, in 17 in the lymph node and in another patient in the spinal canal. This study demonstrates the clinical utility and diagnostic accuracy of FNAC in the evaluation of GS from multiple sites.

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Granulocytic sarcoma (chloroma): CT manifestations.

Cited by 58 publications

References 0 publications

Solitary myeloblastoma presenting as acute hydrocephalus: review of literature, implications for therapy

Solitary myeloblastoma presenting as acute hydrocephalus: review of literature, implications for therapy

Primary Sarcomas of the Central Nervous System

Diagnosis of Granulocytic Sarcoma by Fine-Needle Aspiration Cytology

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