Granulomas não-infecciosos: sarcoidose

Daldon, Patrícia Érica Christofoletti; Arruda, Lúcia Valéria Ramos de

doi:10.1590/s0365-05962007000600010

Cited by 15 publications

(22 citation statements)

References 107 publications

(187 reference statements)

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“…The incidence is around 3–13 % and is clinically relevant only in 2–5 % of cases, often presenting an asymptomatic course [4, 5]. A wide, clinical variability is described in symptomatic cases, from minor manifestations, sometimes self-limiting, to osteolysis and pathologic fracture with involvement of the surrounding soft tissues.…”

Section: Discussionmentioning

confidence: 99%

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Sarcoidosis with prevalent and severe joint localization: a case report

Moccia

Castaldo

Sirignano

et al. 2016

Multidiscip Respir Med

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BackgroundSarcoidosis is a systemic granulomatous disease of unknown origin, characterized by the formation of granulomas without central necrosis. Each organ and tissue can be affected by the disease, but in most cases mainly the lungs and mediastinal lymph nodes but also skin, heart, eyes and joints are involved, the latter are mainly the metacarpophalangeal joints and bone lesions are often associated with involvement of the overlying skin. The diagnosis is often of exclusion, based on clinical and radiological suspicion, and should be confirmed by biopsy, although in each case it is necessary to exclude other possible causes of granulomatosis, including infections by mycobacteria. Here it is reported a case of particularly aggressive sarcoidosis with primitive involvement of the small joints of the hands and feet, and mediastinal lymph nodes.Case presentationThe subject, a man, 60 years old, born in Morocco but living in Italy for many years, presented important involvement of bone structures and soft periarticular tissue, and was affected by the formation of granulomas without “caseum necrosis”. The painful symptoms and the skin ulceration had led to surgical amputation of the distal phalanges of most fingers of his hands and feet, but with subsequent resurgence of lesions in acral locations after surgery. The PET/CT scan showed an amount of radiotracer in mediastinal lymph nodes, while the lymph nodes sampled by TBNA were normal and the CD4/CD8 ratio was less than 3 in the bronchoalveolar lavage. We ruled out any possible infectious cause, including mycobacterial infection (both tubercular and atypical), so the patient was treated with systemic corticosteroids, with an excellent clinical and radiological response.ConclusionsSuch a case shows how the disease can have variable expressions, without primitive lung involvement; therefore, it should be necessary to consider any possible, unpredictable localization of the disease.

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Section: Discussionmentioning

confidence: 99%

“…Osteo-articular manifestations are uncommon, and are often associated with other symptoms [4, 5]. This involvement in patients with sarcoidosis is around 3–13 %, and is clinically relevant only in 2–5 % of cases, presenting frequently an asymptomatic course.…”

Section: Introductionmentioning

confidence: 99%

Sarcoidosis with prevalent and severe joint localization: a case report

Moccia

Castaldo

Sirignano

et al. 2016

Multidiscip Respir Med

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“…4,5 Women are affected at the rate of 1.2:1 with predilection for the black race. 6 Sarcoidosis affects young adults, preferably in the 25 to 40 year old age group, being rare in childhood. A second incidence peak is observed between 45 and 65 years of age.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis simulating syringomas

Rocha

Bringel

Balassiano

et al. 2012

An. Bras. Dermatol.

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Sarcoidosis is a granulomatous disease of unknown etiology. The skin is commonly affected. Cutaneous manifestations can mimic other diseases and autoimmune disorders. The dermatologist plays a critical role in elucidating the clinical diagnosis and assisting other specialists in the investigation of a systemic disease. We report a patient with typical cutaneous manifestation of sarcoidosis with pulmonary involvement.

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“…32,33 Também vale a pena ressaltar que o emprego da biologia molecular pode auxiliar no diagnóstico etiológico diferencial entre as lesões sarcoídicas e da própria sarcoidose. 34,35 Com a descoberta da molécula do ácido desoxirribonucléico (DNA), por Watson e Crick em 1953, o estudo dos tecidos e das células passa da observação morfológica, macroscópica ou microscópica, para a molecular. A biologia molecular, além de sua relevância clínica e epidemiológica, representa um campo em potencial para a pesquisa na área médica.…”

Section: Biologia Molecular E Dermatoses Tropicaisunclassified

Biologia molecular aplicada às dermatoses tropicais

Roselino

2008

An. Bras. Dermatol.

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São apresentados conceitos básicos sobre célula, código genético e síntese protéica, e sobre algumas técnicas de biologia molecular, tais como PCR, PCR-RFLP, seqüenciamento de DNA, RT-PCR e immunoblotting. São fornecidos protocolos de extração de nucleotídeos e de proteínas, como salting out no sangue periférico e métodos do fenol-clorofórmio e do trizol em tecidos. Seguem-se exemplos comentados da aplicação de técnicas de biologia molecular para o diagnóstico etiológico e pesquisa em dermatoses tropicais, com ênfase na leishmaniose tegumentar americana e hanseníase.

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Granulomas não-infecciosos: sarcoidose

Cited by 15 publications

References 107 publications

Sarcoidosis with prevalent and severe joint localization: a case report

Sarcoidosis with prevalent and severe joint localization: a case report

Sarcoidosis simulating syringomas

Biologia molecular aplicada às dermatoses tropicais

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