Granulosa Cell Tumor of the Contralateral Testis in a Man with a History of Cryptorchism

Guzzo, Thomas J.; Gerstein, Matthew; Mydlo, Jack H.

doi:10.1159/000075281

Cited by 13 publications

(4 citation statements)

References 5 publications

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“…Most of the patients with AGCT presented with slowly growing painless testicular masses with several of whom reporting a duration of symptoms for many years [7, 22, 30]. On the other hand, eight cases were sized <1cm that were found incidentally upon autopsy [9] or with ultrasonography [25, 43]. Overall, a palpable mass is probably the typical presenting symptom of AGCT as it is with testicular germ cell tumors [6, 38, 45].…”

Section: Discussionmentioning

confidence: 99%

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature

Dieckmann

Bertolini²,

Wülfing

2019

Case Reports in Urology

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Adult granulosa cell tumor (AGCT) of the testis represents a very rare testicular neoplasm that is poorly understood clinically. Here we report the case of a 22-year-old male who presented with unspecific scrotal symptoms. Scrotal sonography disclosed a 6 mm hypoechoic intratesticular lesion. Histological examination after orchiectomy revealed a homogeneous and well demarcated neoplasm with monomorphic cells with nuclear grooving and microfollicular formation of the so-called Call-Exner bodies. Immunohistology showed positive stainings of vimentin, calretinin, and inhibin with negative stainings of the typical germ cell tumor markers. Thus, the diagnosis of a benign AGCT was made. The patient is well one year after surgery. A total of 91 previous AGCT cases were identified in the literature. Median age of the cases reported to date is 44 years, median tumor size 3.2 cm. 54.3% of the AGCT cases were located on the left side. 12 cases (13.2%) were of malignant nature. Testis-sparing surgery would be the treatment of choice, but only two of all cases had received that procedure. The present report aims to increase the clinical knowledge of AGCT and specifically to increase the clinician’s vigilance with respect to testis-sparing surgery in probably benign testicular masses.

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Section: Discussionmentioning

confidence: 99%

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature

Dieckmann

Bertolini²,

Wülfing

2019

Case Reports in Urology

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“…The adult-type GCT is extremely rare in the testis, Schubert et al [35] have found 43 cases in the literature [1] , [2] , [3] , [4] , [5] , [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] and we were able to find three more recent cases in PubMed ( Table 1 ) [2] , [36] . However, in most of the reports these tumours are only the object of immunohistochemical or cytogenetic investigations; thus, the clinical data are missing partially [5] , [11] , [22] , [24] .…”

Section: Discussionmentioning

confidence: 99%

Adult-type granulosa cell tumour of the testis: Report of a case and review of the literature

Al-Alao

Gul

Al-Ani

et al. 2016

Arab Journal of Urology

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Granulosa cell tumours (GCTs) can be either juvenile or adult type, and more commonly occur in the ovaries. Adult-type GCTs of the testis (AGCTT) are very rare and only 46 cases have previously been reported. We report here on a 48-year-old Filipino man with a left testicular AGCTT, which measured 1.2 × 1.2 × 1.0 cm. He underwent radical orchidectomy with postoperative surveillance for 1 year, which included computed tomography with oral intravenous contrast and clinical examinations, which have been unremarkable. The previously reported AGCTTs were briefly reviewed.

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“…Only 29 cases of adult type testicular granulosa cell tumor have been reported [38][39][40][41][42][43][44][45][46][47]. The average age at presentation is 45 years (range 16 -77 years).…”

Section: Granulosa Cell Tumorsmentioning

confidence: 99%

“…No prominent nucleoli are seen. Mitotic rate is highly variable, ranging from 2 per 50 HPF to 3 per HPF [43,52]. Call-Exner bodies may be seen.…”

Section: Granulosa Cell Tumorsmentioning

confidence: 99%

Gynecomastia: An Uncommon but Important Clinical Manifestation for Testicular Tumors

Bing¹,

Bai²

2012

OJPathology

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Gynecomastia is a benign enlargement of male breast tissue due to the proliferation of the ductal component. It can be physiological or pathological. Gynecomastia can be a sign for testicular tumors including sex-cord stromal tumors and germ cell tumors. Testicular physical examination in combination with testicular untrasonography and serum germ cell tumor markers when necessary in the presence of gynecomastia can help to reach a correct diagnosis.

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Granulosa Cell Tumor of the Contralateral Testis in a Man with a History of Cryptorchism

Cited by 13 publications

References 5 publications

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature

Adult Granulosa Cell Tumor of the Testis: A Case Report with a Review of the Literature

Adult-type granulosa cell tumour of the testis: Report of a case and review of the literature

Gynecomastia: An Uncommon but Important Clinical Manifestation for Testicular Tumors

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