Granulosa theca cell tumours

McKinnon, AO; Barker, K. J.

doi:10.2746/095777309x480533

Cited by 9 publications

(4 citation statements)

References 10 publications

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“…Hypofunction of the contralateral ovary characterized by small hypoechoic follicle seen on ultrasound imaging (Figure 1). This was consistent with the findings of many researchers (Watson, 1999;McCue et al, 2006;Gündüz et al, 2010;McKinnon and Barker, 2010) which stated that a horse with GTCT on one of its ovaries usually followed by hypofunction of contralateral ovary. Proliferative granulosa cells secrete inhibin which affects the low level of the FSH concentration, leading to atrophy of the contralateral ovary (Zelli et al, 2006;Ellenberger et al, 2007).…”

Section: Resultssupporting

confidence: 92%

Prevalence of Mares’ Granulosa Theca Cell Tumor (Gtct) in Indonesia

et al. 2020

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This study was conducted to determine the prevalence rate of mares’ GTCT in Indonesia. Ultrasound examination of ovaries were performed on mares in Java and Madura Island of Indonesia. Thirteen mares had been affected by GTCT from 2913 number of examinations. The prevalence rate of GTCT during year 2006 and 2007 were 4.71% and 5.56%, respectively followed by a decrease in prevalence rate of GTCT during 2008-2014. The reproductive cycle in a mare with GTCT had returned to normal 6 months after ovariectomy.

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Section: Resultssupporting

confidence: 92%

Prevalence of Mares’ Granulosa Theca Cell Tumor (Gtct) in Indonesia

et al. 2020

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“…Although serum concentrations of AMH and inhibin were related in mares with GCTs, serum AMH concentrations appear to have a much broader dynamic range than do serum inhibin concentrations. This may, in part, reflect the relatively long half-life of AMH (1.5-2 days; [15]) compared to inhibin (approximately 1 h; [28]) in addition to the strong but variable expression of AMH by equine GCTs.…”

Section: Discussionmentioning

confidence: 99%

Determination of serum anti‐Müllerian hormone concentrations for the diagnosis of granulosa‐cell tumours in mares

Ball

Almeida

Conley

2012

Equine Veterinary Journal

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“…In fact, GCT can be found in mares of any age, but the average age of affected mares is 11 years. Juvenile GCTs are very rare and have presented often with hemoperitoneum in weanlings in other studies ( Green et al , 1988 ; McKinnon and Barker, 2010 ). Why GCTs in young horses tend to grow so fast and produce hemorrhages is not entirely clear, but could be related to the stage of hormonal development in which weanlings are involved.…”

Section: Discussionmentioning

confidence: 88%

Successful intra-abdominal resection of a 24 kg ovarian granulosa cell tumour in a Warmblood mare

Tommasa,

Roth,

Triebe

et al. 2023

Open Vet J

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Background: Granulosa cell tumours (GCT) are the most common ovarian tumours in mares. The classical presentation of a GCT is a unilaterally enlarged ovary appearing as a multicystic honeycomb mass. In rare cases, GCTs cause haemoperitoneum as a result of rapid growth of the tumour. The clinical diagnosis of GCT is usually based on history, rectal examination, ultrasonographic examination and serum hormone analysis, and surgical removal of the affected ovary is the treatment of choice. The different surgical approaches are based on the dimension of the GCT. Case description: A 7-year-old mare was referred to the department for horses due to suspicion of a large colon impaction. The mare presented with clinical signs of colic, fever and signs of hypovolemic shock. Rectal and ultrasonographic examination showed haemoperitoneum and a honey-comb mass within the abdomen, and a granulosa cell tumour (GCT) as the cause of an acute haemoperitoneum was diagnosed based on the serum level of Anti-Müllerian hormone. After stabilization of the mare, the GCT was removed through a ventral midline incision. Because of the enormous dimensions of the GCT, intra-abdominal partial resection of the tumour using a tenotomy knife was necessary to exteriorize the ovarian pedicle. At 3 months follow-up, the mare was ridden for her intended use. Conclusion: This report provides an approach to an uncommon case of a very large and heavy GCT.

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Granulosa theca cell tumours

Cited by 9 publications

References 10 publications

Prevalence of Mares’ Granulosa Theca Cell Tumor (Gtct) in Indonesia

Prevalence of Mares’ Granulosa Theca Cell Tumor (Gtct) in Indonesia

Determination of serum anti‐Müllerian hormone concentrations for the diagnosis of granulosa‐cell tumours in mares

Successful intra-abdominal resection of a 24 kg ovarian granulosa cell tumour in a Warmblood mare

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