Graphene as Tunable Stationary Phase Additive for Enantioseparation

Abstract

Graphene-based biosensor and chiral sensor have made significant progress in recent years. Because of the similarity of the optical enantiomers, enantioseparation is perhaps the most subtle to achieve. Developing more effectively chiral separation techniques based on graphene is highly desirable. Herein, pristine graphene was prepared and then applicated to assist resolution of two racemic drugs of propranolol and ofloxacin using thin-layer chromatography (TLC). In comparison with TLC chiral separation by only using pure D-(-)-tartaric acid as a selector with relatively low degree of separation, a mixture of graphene and D-(-)-tartaric acid is more attractive, efficient and ready available. The high specific resolution ability for racemic compounds aided by graphene might allow its potential application in future chiral separation technologies.

Removal of methylene blue from water by graphene oxide aerogel: thermodynamic, kinetic, and equilibrium modeling

“…In the past a few years, graphene oxide (GO) and graphene nanosheets have attracted tremendous interest in various applications such as photocatalysts, batteries, supercapacitors, sensors, pharmaceutical and environmental pollution management [4][5][6][7][8][9][10]. GO is an oxidized form of graphene in vigorous oxidation conditions.…”

“…GO is an oxidized form of graphene in vigorous oxidation conditions. After seminal works of B. C. Brodie on flake graphite in 1859, Hummers and his coworkers made some modifications on oxidation of graphite by use of H 2 SO 4 and KMnO 4 , which has been a basis of the present chemical methods for GO production [11]. GO is formed from graphene sheets with one atom in thickness and generally surrounded by polar functional groups (-OH, -COOH, epoxy groups) [12].…”

Enantiomeric Recognition and Separation by Chiral Nanoparticles

“…Notably, graphene and GO exhibit considerable potential in separation science [165] and has been used by several research groups for the enantiomeric separation of chiral molecules. For instance, Tu et al [106] reported the graphene assisted resolution of two racemic drugs propranolol and ofloxacin using pure d -(–)-TA as the chiral selector in TLC. Interestingly, computational simulations using density functional theory also showed the applicability of nanoporous graphene, when functionalized by a chiral bouncer molecule [171].…”

Betamethasone‐based chiral electrochemical sensor coupled to chemometric methods for determination of mandelic acid enantiomers

“…The enantioselective sensing in electrochemical techniques is due to the enantioselective interaction between a chiral selector and the chiral analyte . Chiral selectors with different spacial arrangements of functional groups including amino, hydroxyl, carbonyl, phenyl, and carboxyl groups are responsible for chiral recognition characteristic of the modified electrode . The presence of 9 chiral centers as well as possessing the hydroxyl, fluorine, and carbonyl groups with hydrogen bonding capability can contribute to chiral recognition ability of BMZ (Scheme ).…”

“…18 Chiral selectors with different spacial arrangements of functional groups including amino, hydroxyl, carbonyl, phenyl, and carboxyl groups are responsible for chiral recognition characteristic of the modified electrode. 19 The presence of 9 chiral centers as well as possessing the hydroxyl, fluorine, and carbonyl groups with hydrogen bonding capability can contribute to chiral recognition ability of BMZ (Scheme 1). In spite of BMZ chirality and its enantio-recognition potentiality, there was no report on using of BMZ as chiral selector.…”