Graphene@AuNPs modified molecularly imprinted electrochemical sensor for the determination of colchicine in pharmaceuticals and serum

Bai, Huiyu; Wang, Chunqiong; Jin, Chen; Li, Zixuan; Fu, Kaixin; Cao, Qiue

doi:10.1016/j.jelechem.2018.02.061

Cited by 27 publications

(5 citation statements)

References 33 publications

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“…EIS analysis: Electrochemical impedance spectroscopy (EIS) is an informative, non-destructive method and is used to monitor the preparation process and to determine properties of the modified electrode [16][17][18]. The experimental impedance spectra were fitted by computer simulation using an equivalent electronic circuit based on Randles-Ershler theoretical model [19,20]. Fig.…”

Section: Resultsmentioning

confidence: 99%

Detection of Colchicine using p-Sulfonated Calix[4]arene Modified Electrode

Pang

Zhang

2019

Asian J. Chem.

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Complex characteristics of p-sulfonated calix[4]arene (SC4A) and colchicine were examined using various techniques. Electrochemical impedance spectroscopy results enabled observation of the colchicine-SC4A interaction, and indicated that SC4A had high sensitivity to colchicine with a detection limit (S/N = 3) of 2 × 10-9 mol L-1. Cyclic voltammetry results indicated that the structural matching effect and the electrostatic interaction were the dominant stabilizing factors for the host-guest complexes of colchicine and SC4A. Molecular mechanics simulation showed that the benzene ring of colchicine entered the SC4A cavity. The sensor enabled selective determination of colchicine even in the presence of common interferences. The results indicated that it was more difficult to oxidize the non-electrochemically active complexes. This study showed that p-sulfonated calix[4]arene can be used in the detoxification of colchicine poisoning and may be effective in the clinical treatment of colchicine poisoning in the future.

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Section: Resultsmentioning

confidence: 99%

Detection of Colchicine using p-Sulfonated Calix[4]arene Modified Electrode

Pang

Zhang

2019

Asian J. Chem.

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“…al. [118] to detect the agent with seven fold higher current compared with a simple MIP/GC electrode; recoveries of 99–110 % were seen for tablet and serum analysis. Beytur et.…”

Section: Mip Based Voltammetric Sensorsmentioning

confidence: 99%

“…Choice is guided by final electrode robustness, reproducibility, cost and stability (Table 2). As well as the MIP phase, added materials are used with the emphasis on nanocarbons, metallic/metallic oxide nanoparticles increasing [115–118]. Beyond function, thermo mechanical strength may thus be increased.…”

Section: Mip Based Voltammetric Sensorsmentioning

confidence: 99%

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feroz

Vadgama

2020

Electroanalysis

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Molecular imprinted polymers (MIPs) are tailor made from synthetic polymers and designed to mimic the recognition properties of natural biological affinity molecules. MIPs incorporate binding motifs complementary to target organic molecule shape and functional groups in order to mimic the complex binding surfaces of natural macromolecules. This confers selectivity and specificity, with the added advantage of artificial MIP polymer stability and ready adaptability to the fabrication and creation of miniaturised affinity interfaces for electrochemical sensing and extra‐laboratory testing. Their generic capability as robust sorbent phases for drug extraction and concentration allows for targeted, interfacial interrogation by the active electrochemical surface. A wide range of electrochemical sensing strategies has also been advanced in recent years, which is covered by this review. The review covers MIP functional principles, examples of MIP preparative routes and final assay outcomes for the measurement of small molecule drugs of biomedical, and also of potential environmental relevance. Some small molecules as examples of toxin and contaminant measurement are also given. A historic background to MIP development is provided, but the review mainly focuses on electrochemical sensor advances in the last five years.

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“…In this way, a molecular shape memory will induce in MIP. The organized architecture is capable of selective uptake of the target analyte even in the presence of structurally alike interfering analogs (Haupt, 2003; Bai et al , 2018).…”

Section: Molecularly Imprinted Polymer In Diagnosticmentioning

confidence: 99%

Feasibility study on molecularly imprinted assays for biomedical diagnostics

Ang

Low

2019

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Purpose Molecularly imprinted polymers (MIPs) have aroused focus in medicinal chemistry in recent decades, especially for biomedical applications. Considering the exceptional abilities to immobilize any guest of medical interest (antibodies, enzymes, etc.), MIPs is attractive to substantial research efforts in complementing the quest of biomimetic recognition systems. This study aims to review the key-concepts of molecular imprinting, particularly emphasizes on the conformational adaptability of MIPs beyond the usual description of molecular recognition. The optimal morphological integrity was also outlined in this review to acknowledge the successful sensing activities by MIPs. Design/methodology/approach This review highlighted the fundamental mechanisms and underlying challenges of MIPs from the preparation stage to sensor applications. The progress of electrochemical and optical sensing using molecularly imprinted assays has also been furnished, with the evolvement of molecular imprinting as a research hotspot. Findings The lack of standard synthesis protocol has brought about an intriguing open question in the selection of building blocks that are biocompatible to the imprint species of medical interest. Thus, in this paper, the shortcomings associated with the applications of MIPs in electrochemical and optical sensing were addressed using the existing literature besides pointing out possible solutions. Future perspectives in the vast development of MIPs also been postulated in this paper. Originality/value The present review intends to furnish the underlying mechanisms of MIPs in biomedical diagnostics, with the aim in electrochemical and optical sensing while hypothesizing on future possibilities.

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Graphene@AuNPs modified molecularly imprinted electrochemical sensor for the determination of colchicine in pharmaceuticals and serum

Cited by 27 publications

References 33 publications

Detection of Colchicine using p-Sulfonated Calix[4]arene Modified Electrode

Detection of Colchicine using p-Sulfonated Calix[4]arene Modified Electrode

Molecular Imprinted Polymer Modified Electrochemical Sensors for Small Drug Analysis: Progress to Practical Application

Feasibility study on molecularly imprinted assays for biomedical diagnostics

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