Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement

Lascano, Sheila; Chávez-Vásconez, Ricardo; Muñoz-Rojas, Daniela; Aristizábal, Juliet; Arce, Bárbara; Parra, Carolina; Acevedo, Cristián; Orellana, Nicole; Reyes-Valenzuela, Mauricio; Gotor, F.J.; Arévalo, Cristina; Torres, Yadir

doi:10.1016/j.surfcoat.2020.126250

Cited by 16 publications

(9 citation statements)

References 104 publications

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“…Lascano et al [54] investigated the use of a Ti-β alloys, composed of Ti-Nb-Ta-xMn (x: 2, 4, and 6 wt%) and with a lower elastic modulus compared to the c.p. titanium.…”

Section: Biomaterials Compositionmentioning

confidence: 99%

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

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An increase in the world population and its life expectancy, as well as the ongoing concern about our physical appearance, have elevated the relevance of dental implantology in recent decades. Engineering strategies to improve the survival rate of dental implants have been widely investigated, focusing on implant material composition, geometry (usually guided to reduce stiffness), and interface surrounding tissues. Although efforts to develop different implant surface modifications are being applied in commercial dental prostheses today, the inclusion of surface coatings has gained special interest, as they can be tailored to efficiently enhance osseointegration, as well as to reduce bacterial-related infection, minimizing peri-implantitis appearance and its associated risks. The use of biomaterials to replace teeth has highlighted the need for the development of reliable analytical methods to assess the therapeutic benefits of implants. This literature review considers the state-of-the-art strategies for surface modification or coating and analytical methodologies for increasing the survival rate for teeth restoration.

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“…Lascano et al [54] investigated the use of a Ti-β alloys, composed of Ti-Nb-Ta-xMn (x: 2, 4, and 6 wt%) and with a lower elastic modulus compared to the c.p. titanium.…”

Section: Biomaterials Compositionmentioning

confidence: 99%

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

et al. 2022

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“…However, there is mismatch between the stiffness of bone and metallic biomaterials. This incompatibility generates the stress-shielding phenomenon which promotes bone resorption at the implant–bone interface and can even induce implant failure [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Powder metallurgy, in combination with the space-holder technique, represents a cost-effective and flexible way to obtain components with a high-degree of porosity (35–80%) and a homogeneous distribution of pores throughout the volume [ 15 , 16 , 17 ]. Particles commonly used as space-holders include NH 4 HCO 3 [ 5 , 18 , 19 , 20 , 21 , 22 ], NaCl [ 17 , 18 , 21 , 23 , 24 ], starch [ 25 , 26 ], Mg [ 27 , 28 , 29 ], PMMA [ 30 , 31 ], saccharose crystals [ 26 , 32 ], PVA [ 33 ], and carbamide [ 15 , 34 , 35 ], which can be eliminated at a relatively low temperature, or can be easily removed by a dissolution process, generally in water [ 3 ]. NH 4 HCO 3 is one of the preferred spacer particles due to its moderate decomposition temperature, which makes it easily and completely removable, ensuring a low uptake of impurities such as oxygen, nitrogen, and carbon [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of the Processing Parameters on the Porosity and Mechanical Behavior of Titanium Samples with Bimodal Microstructure Produced via Hot Pressing

et al. 2021

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Commercially pure (c.p.) titanium grade IV with a bimodal microstructure is a promising material for biomedical implants. The influence of the processing parameters on the physical, microstructural, and mechanical properties was investigated. The bimodal microstructure was achieved from the blends of powder particles with different sizes, while the porous structure was obtained using the space-holder technique (50 vol.% of ammonium bicarbonate). Mechanically milled powders (10 and 20 h) were mixed in 50 wt.% or 75 wt.% with c.p. titanium. Four different mixtures of powders were precompacted via uniaxial cold pressing at 400 MPa. Then, the specimens were sintered at 750 °C via hot pressing in an argon gas atmosphere. The presence of a bimodal microstructure, comprised of small-grain regions separated by coarse-grain ones, was confirmed by optical and scanning electron microscopies. The samples with a bimodal microstructure exhibited an increase in the porosity compared with the commercially available pure Ti. In addition, the hardness was increased while the Young’s modulus was decreased in the specimens with 75 wt.% of the milled powders (20 h).

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“…The coatings revealed to be biocompatible and to favor cellular growth and adhesion, thus improving the properties of the substrate. The positive results were attributed to the impermeability of graphene to metallic ions, preventing the contact between cells and metal ions in the porous structure ( Lascano et al, 2020 ).…”

Section: Dm Coatings and Cellular Interactionmentioning

confidence: 99%

Interactions Between 2D Materials and Living Matter: A Review on Graphene and Hexagonal Boron Nitride Coatings

Santos

Moschetta

Rodrigues

et al. 2021

Front. Bioeng. Biotechnol.

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Two-dimensional material (2DM) coatings exhibit complex and controversial interactions with biological matter, having shown in different contexts to induce bacterial cell death and contribute to mammalian cell growth and proliferation in vitro and tissue differentiation in vivo. Although several reports indicate that the morphologic and electronic properties of the coating, as well as its surface features (e.g., crystallinity, wettability, and chemistry), play a key role in the biological interaction, these kinds of interactions have not been fully understood yet. In this review, we report and classify the cellular interaction mechanisms observed in graphene and hexagonal boron nitride (hBN) coatings. Graphene and hBN were chosen as study materials to gauge the effect of two atomic-thick coatings with analogous lattice structure yet dissimilar electrical properties upon contact with living matter, allowing to discern among the observed effects and link them to specific material properties. In our analysis, we also considered the influence of crystallinity and surface roughness, detailing the mechanisms of interaction that make specific coatings of these 2DMs either hostile toward bacterial cells or innocuous for mammalian cells. In doing this, we discriminate among the material and surface properties, which are often strictly connected to the 2DM production technique, coating deposition and post-processing method. Building on this knowledge, the selection of 2DM coatings based on their specific characteristics will allow to engineer desired functionalities and devices. Antibacterial coatings to prevent biofouling, biocompatible platforms suitable for biomedical applications (e.g., wound healing, tissue repairing and regeneration, and novel biosensing devices) could be realized in the next future. Overall, a clear understanding on how the 2DM coating’s properties may modulate a specific bacterial or cellular response is crucial for any future innovation in the field.

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Graphene-coated Ti-Nb-Ta-Mn foams: A promising approach towards a suitable biomaterial for bone replacement

Cited by 16 publications

References 104 publications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Latest Trends in Surface Modification for Dental Implantology: Innovative Developments and Analytical Applications

Effect of the Processing Parameters on the Porosity and Mechanical Behavior of Titanium Samples with Bimodal Microstructure Produced via Hot Pressing

Interactions Between 2D Materials and Living Matter: A Review on Graphene and Hexagonal Boron Nitride Coatings

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