Gray Matter Alterations in First-Admission Adolescents with Schizophrenia

Henze, Romy; Brunner, Romuald; Thiemann, Ulf; Parzer, Peter; Richterich, Andreas; Essig, Marco; Resch, Franz; Stieltjes, Bram

doi:10.1111/j.1552-6569.2010.00504.x

Cited by 21 publications

(19 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Significant N80 amplitude reductions in response to mixed M-P conditions, regarded as an electrophysiological correlate of the M priming, were observed in early onset schizophrenia patients many years after first-episode, but not in adult onset patients (Núñez et al, 2013). This finding points toward an M priming deficit in early onset patients and is compatible with the neurodevelopmental hypothesis of schizophrenia, probably reflecting brain maturational abnormalities of visual area V1/V2 (Henze et al, 2010;Schultz et al, 2011) and parietal lobes (Kumra et al, 2004) which play an important role in visual information processing. Evidence coming from behavioral studies indicates that M impairments are linked to visual symptoms in the early stages of the illness (Kéri and Benedek, 2007), probably leading to both disturbed highlighting of relevant information and slower visual information processing (Kiss et al, 2010).…”

supporting

confidence: 58%

Do deficits in the magnocellular priming underlie visual derealization phenomena? Preliminary neurophysiological and self-report results in first-episode schizophrenia patients

Núñez

Oelkers-Ax

Slatman

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

supporting

confidence: 58%

Do deficits in the magnocellular priming underlie visual derealization phenomena? Preliminary neurophysiological and self-report results in first-episode schizophrenia patients

Núñez

Oelkers-Ax

Slatman

et al. 2014

Schizophrenia Research

View full text Add to dashboard Cite

“…Strong evidence has recently emerged of a much more fundamental role for the cerebellum in higher cognitive processing than was previously considered 53, 68 . Accordingly, cerebellar volume changes were observed in patients with various mental disorders 69–71 , and that those with cerebellar damage had cognitive abnormalities in various domains 72, 73 . In this light, one might expect the cerebellar component to be associated with TMT-B (or TMT-B minus TMT-A), which measures the ability to control attention and set-shifting 32 .…”

Section: Discussionmentioning

confidence: 99%

Brain Structural Networks Associated with Intelligence and Visuomotor Ability

Yoon

Shin

Lee

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Increasing evidence indicates that multiple structures in the brain are associated with intelligence and cognitive function at the network level. The association between the grey matter (GM) structural network and intelligence and cognition is not well understood. We applied a multivariate approach to identify the pattern of GM and link the structural network to intelligence and cognitive functions. Structural magnetic resonance imaging was acquired from 92 healthy individuals. Source-based morphometry analysis was applied to the imaging data to extract GM structural covariance. We assessed the intelligence, verbal fluency, processing speed, and executive functioning of the participants and further investigated the correlations of the GM structural networks with intelligence and cognitive functions. Six GM structural networks were identified. The cerebello-parietal component and the frontal component were significantly associated with intelligence. The parietal and frontal regions were each distinctively associated with intelligence by maintaining structural networks with the cerebellum and the temporal region, respectively. The cerebellar component was associated with visuomotor ability. Our results support the parieto-frontal integration theory of intelligence by demonstrating how each core region for intelligence works in concert with other regions. In addition, we revealed how the cerebellum is associated with intelligence and cognitive functions.

show abstract

“…preadolescents with psychotic-like experiences with matched healthy controls, an initial set of experiments showed functional changes encompassing the error-related processing network, 83 the perspective-taking network, 84 and the status of intrinsic functional connectivity within the inhibitory control network, 85 in line with behavioral findings previously mentioned (see “ToM in Children With Hallucinations” section). Such differences measured in the blood-oxygen-level-dependent (BOLD) signal—during cognitive tasks and at rest—were shown to be associated with gray matter 83,86 and event-related potentials changes 87 in at-risk or first-episode adolescents compared with controls, supporting a hypothesis of distributed neural impairments associated with the psychosis phenotype in general.…”

Section: Cognitive Theories Of Hallucinations In Children and Adolescmentioning

confidence: 91%

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

Jardri

Bartels-Velthuis

Debbané

et al. 2014

Schizophrenia Bulletin

View full text Add to dashboard Cite

Typically reported as vivid, multisensory experiences which may spontaneously resolve, hallucinations are present at high rates during childhood. The risk of associated psychopathology is a major cause of concern. On the one hand, the risk of developing further delusional ideation has been shown to be reduced by better theory of mind skills. On the other hand, ideas of reference, passivity phenomena, and misidentification syndrome have been shown to increase the risk of self-injury or heteroaggressive behaviors. Cognitive psychology and brain-imaging studies have advanced our knowledge of the mechanisms underlying these early-onset hallucinations. Notably, specific functional impairments have been associated with certain phenomenological characteristics of hallucinations in youths, including intrusiveness and the sense of reality. In this review, we provide an update of associated epidemiological and phenomenological factors (including sociocultural context, social adversity, and genetics, considered in relation to the psychosis continuum hypothesis), cognitive models, and neurophysiological findings concerning hallucinations in children and adolescents. Key issues that have interfered with progress are considered and recommendations for future studies are provided.

show abstract

Gray Matter Alterations in First-Admission Adolescents with Schizophrenia

Abstract: These findings support cerebellar involvement in the pathogenesis of schizophrenia, and the alterations observed in several parts of the visual system may provide insights into the nature of hallucinations and delusional interpretations.

Cited by 21 publications

References 43 publications

Do deficits in the magnocellular priming underlie visual derealization phenomena? Preliminary neurophysiological and self-report results in first-episode schizophrenia patients

Do deficits in the magnocellular priming underlie visual derealization phenomena? Preliminary neurophysiological and self-report results in first-episode schizophrenia patients

Brain Structural Networks Associated with Intelligence and Visuomotor Ability

From Phenomenology to Neurophysiological Understanding of Hallucinations in Children and Adolescents

Contact Info

Product

Resources

About