Green and rapid synthesis of silver nanoparticles usingBorago officinalisleaf extract: anticancer and antibacterial activities

Abstract

This study highlights the facile, reliable, cost effective, and ecofriendly synthesis of silver nanoparticles (AgNPs) using Borago officinalis leaves extract efficiently. The biosynthesis of AgNPs was verified by UV-Vis spectrum which showed the surface plasmon resonance (SPR) band at 422 nm. Transmission electron microscope (TEM) analysis revealed that the particles were spherical, hexagonal, and irregular in shape and had size ranging from 30 to 80 nm. The energy dispersive X-ray spectroscopy (EDX) and elemental mapping have displayed the purity and maximum distribution of silver in the AgNPs. The crystalline nature of AgNPs had been identified using X-ray diffraction (XRD) and selected area diffraction pattern (SAED). The particle size analysis revealed that the Z-average diameter of the AgNPs was 50.86 nm with polydispersity index (PDI) 0.136. Zeta potential analysis displayed the colloidal stability of AgNPs. This work also showed the efficacy of AgNPs against lung cancer cell lines (A549) and cervical cancer cell line (HeLa), in vitro. The AgNPs showed cytotoxicity to the A549 and HeLa cancer cell line at the concentrations 5 and 2 μg/ml. The AgNPs were also explored for the antibacterial activity including biofilm inhibition against pathogenic bacteria. The B. officinalis leaves extract can be used efficiently for green synthesis AgNPs. The biosynthesized AgNPs demonstrated potentials as anticancer and antibacterial agents. This work provides helpful insight into the development of new anticancer and antimicrobial agents.

Green synthesis of silver nanoparticles using leaf extract of medicinally potent plant Saraca indica: a novel study

“…Nanoparticles, which are made from comparatively larger bulk material exhibit new and improved properties depending on their relative size, distribution and morphology (Li et al 2012). Nanoparticles present a higher surface to volume ratio with decreasing size (Singh et al 2010). The biological effectiveness and value of nanoparticles increase proportionally with an increase in the specific surface area which is due to the increase in their surface energy and catalytic reactivity and also due to changes in physical, mechanical, optical and electromagnetic properties (Pradeep and Anshup 2009;Choi et al 2007;Reddy et al 2008;Okuda et al 2005;Lala et al 2007).…”

Rhizome extracts of <i>Acorus odoratus</i>: Antifungal, anti-yeast, anti-oxidant and HPLC quantification

“…The antifungal potential of extracts from different plant parts of A. odoratus, nevertheless, has been reported in various studies like Kumar et al (2014), Singh et al (2010), Ganjewala (2009), Phongpaichit et al (2005) and Mungkornasawakul et al (2002).…”

Green Silver Nanoparticles: Novel Therapeutic Potential for Cancer and Microbial Infections

“…A key point in anticancer therapy is to have drugs or molecules that are highly selective to kill cancer cells. In the literature there are green silver nanoparticles with anticancer activity but their cytotoxic effects have not been evaluated in normal cells [21,30,33,37,39,42], others show that there is little selectivity for cancer cells [14,34] and other studies show encouraging anticancer activity due to a better degree of selectivity [32,35,36,40,41,43,45]. An advantage of the use of medicinal plant extracts is the opportunity to be able to functionalize silver nanoparticles to enhance their anticancer effect and improve their specificity of action on cancer cells without affecting nontumor cells; this represents a challenge for scientists.…”