Green Approaches to Synthesize Organic Compounds and Drugs

Murti, Yogesh; Pathak, Devender; Pathak, Kamla

doi:10.1007/978-3-030-44176-0_8

Cited by 3 publications

(1 citation statement)

References 61 publications

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“…13 Nevertheless, in modern pharmaceutical exploration, the sustainable synthesis of medication without waste production or the use of protecting groups is gaining significant attention that entirely matches the principle of atom economy and “Green Chemistry”. 14 Multicomponent reactions (MCRs) are one of the best strategies in response to this challenge. Their high convergence, benign conditions, efficiency, atom economy, and associated step economy accompanied by their broad adaptability with eco-friendly solvents make them a superior green synthetic approach.…”

Section: Introductionmentioning

confidence: 99%

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

et al. 2023

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Solvent‐Free Single‐Pot Mannich Reaction and Detoxification of Industrial Hazardous Waste Methyl Mercaptan Gas

et al. 2021

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Environment pollution is causing serious human health issues and forest deterioration. Methyl mercaptan is a malodorous gaseous pollutant, which is a by product of sewage treatment plants, pulp plants, petrochemical plants, agrochemicals, and some pharmaceutical products. A long term exposure to methyl mercaptan may lead to adverse effects on central nervous system and cardiovascular system. The pharmaceutical industries are devoting significant efforts to develop process by using green solvents like water, and develop solvent‐free reactions. This will help to develop green, sustainable methods for the synthesis of API and reduce the manufacturing cost. A ZnCl2 catalyzed solvent‐free, one‐pot process for the synthesis of ranitidine and quenching of hazardous waste methyl mercaptan gas to a useful product have been developed.

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Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

Parveen

Naseem

Shah

et al. 2023

CBC

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Background: A new series of malonic acid-based hydrazide derivatives (BPMPDH, 2HPMPDH, 3HPMPDH, 4HPMPDH, DMPDH) are successfully synthesized by the reaction of malonic ester hydrazide with various substituted aldehydes like salicylaldehyde, benzaldehyde, 4-hydroxy benzaldehyde, 3-hydroxy benzaldehyde and formaldehyde) Methods: metal complexes of prepared hydrazide derivatives were prepared using metals like Cu+2, Zn+2 and Ni+2 via a mild, efficient and convenient method. Newly synthesized compounds were characterized by IR, NMR (1H & 13C), UV/VIS and mass spectrometry. The presence of –C=N- peak at 1600-1700 cm-1 with the absence of NH2 peak at 3500 cm-1 in FTIR spectra. In 1HNMR peak at, 11.00-13.00 ppm for –OH protons and 7.00-9.50 ppm for –NH verified the synthesis of new hydrazide derivatives. The presence of a C-OH sharp peak at 180-190 ppm, a C=O peak at 160-170 ppm and a C=N peak at 140-150 ppm confirmed synthesis. In mass spectra, the molecular ion peaks at 308 m/z, 340 m/z and 156 m/z confirmed synthesis. Synthesized compounds have also been analyzed for their antioxidant, antibacterial, antifungal, chymotrypsin and tyrosinase inhibition activities Result and Conclusion: The results revealed that the 2HPMPDH, 3HPMPDH, 4HPMPDH and their Cu+2 and Zn+2 metal complexes showed more successful inhibition against standard drugs, based on structure activity relationship.

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Green Approaches to Synthesize Organic Compounds and Drugs

Cited by 3 publications

References 61 publications

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

Sustainable synthesis of structures containing quinoxaline-pseudopeptide-triazole pharmacophoresviaa one-pot six-component reaction

Solvent‐Free Single‐Pot Mannich Reaction and Detoxification of Industrial Hazardous Waste Methyl Mercaptan Gas

Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

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