Green extraction of five target phenolic acids from Lonicerae japonicae Flos with deep eutectic solvent

Xiao, Pei; Duan, Minghui; Yao, Xiaohui; Zhang, Yuhang; Zhao, Chunjian; Zu, Yuangang; Fu, Yujie

doi:10.1016/j.seppur.2015.10.065

Cited by 182 publications

(112 citation statements)

References 24 publications

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“…Polarity is another important characteristic that significantly enhances the solubility capacity of DES for extracting the targeted compounds. However, an extreme amount of water would decrease the extraction yield because the hydrogen bond between alcohol and ChCl can be broken by excessive water, which decreases the DES‐targeted compounds interactions continuously . So, a proper amount of water in the DES mixture is required to enhance the extraction yields effectively.…”

Section: Resultsmentioning

confidence: 99%

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

2018

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BACKGROUND Biomass waste, including fruit and vegetable residues, poses a serious challenge to the environment. This demands novel approaches for handling and disposing of it in a safe manner. However, such waste is extremely rich in bioactive components, which are considered to have a beneficial impact on health. This has led to the recovery of high‐value compounds from biomass waste before finally disposing of it. The present investigation reveals the use of green solvents such as eutectic mixtures composed of choline chloride with three different hydrogen bond donors like sucrose (4:1), urea (1:2), and sorbitol (3:1) as extractants for recovering valuable phenolic antioxidants from onion peel. RESULTS A deep eutectic solvent system consisting of choline chloride:urea (ChCl:urea) showed the best result for total phenolic content from onion peel while the other two eutectic mixtures showed relatively lower extraction efficiency. Experiments were performed with different molar ratios of ChCl:U (1:1–1:3) and liquid–solid ratios (10:1–60:1) under a temperature range (50–90 °C) and a time range (60–150 min). Taguchi's method was employed to maximize the extraction of polyphenolic antioxidants from onion peel, resulting in optimal conditions: extraction temperature 60 °C, time 120 min, liquid to solid ratio 50:1 and molar ratio of ChCl:U as 1:2. Under optimum conditions, the corresponding TPC value of the extract was found to be highest at 222.97 mg gallic acid equivalent (GAE) g−1 dw. CONCLUSION Major flavonoids – quercetin, kaempferol, and myricetin – were identified and quantified in the extracts. Moreover, high reducing power (PR) value was reported in the case of ChCl:U extract, and 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) radical scavenging activity was found to be higher in ChCl:So extract. © 2018 Society of Chemical Industry

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Section: Resultsmentioning

confidence: 99%

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

2018

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“…In deep eutectic solvents, hydrogen bond donors mix with hydrogen bond acceptors in a 250 ml reaction flask at 80°C under vigorous agitation for 60 min. After that a homogeneous liquid formed [8]. So in this research choline chloride and glycerol (1:2) were mixed in a 250 ml reaction flask at 80°C for 60 min on a magnetic stirrer.…”

Section: Deep Eutectic Solvent Preparationmentioning

confidence: 99%

Antioxidant and Total Phenolic Content of Catharanthus roseus Using Deep Eutectic Solvent

Nisar¹,

Mamat²,

Hatim³

et al. 2017

Recent Advances in Biology and Medicine

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Deep eutectic solvents as a new type of eco-friendly solvents have attracted attention in chemistry, medicine, and other fields for the extraction and separation of target compounds from medicinal plants. Deep eutectic solvents are easy to prepare and have many advantages as solvents, such as chemical inertness with water, low cost, easy biodegradability, and pharmaceutically acceptable toxicity. In this study, a deep eutectic solvent made up of choline chloride-glycerol (1:2) was used for the extraction of flavonoids from Catharanthus roseus plant parts (flower petal, leaves, stem, and root). The highest amount of phenolic content was detected in flower petal, that is, 194.50 mg GAE/g. In DPPH test, the maximum amount of antioxidant activity determined in the flower petal was 73.13%; IC 50 was calculated by using a linear regression equation; IC 50 value of the standard, stem, root, leaf, and flower petal was 13.22, 90.44, 83.93, 120.14, 79.49 μg/ml, respectively. The result of this research is that Catharanthus roseus has a compatible antioxidant activity. This can be helpful for the treatment of diseases caused by free-radical oxidative stress.

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“…According to the Peng et al [21] DESs were prepared easily by the heating method, in which hydrogen-bond donors mixed with hydrogen-bond acceptors in the reaction flask for 60 min at 808C under vigorous agitation to get the homogeneous liquid. In this research choline chloride and glycerol at 1:2 ratio were mixed in the in a reaction flask at 808C for 60 min on a magnetic stirrer.…”

Section: Deep Eutectic Solvents Preparationmentioning

confidence: 99%

Identification of Flavonoids (Quercetin, Gallic acid and Rutin) from Catharanthus roseus Plant Parts using Deep Eutectic Solvent

Nisar¹,

Mamat²,

Hatim³

et al. 2017

Recent Advances in Biology and Medicine

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Green technology is the most important topic in the pharmaceutical field because it reduces the cost of medicines and minimizes the environmental impact of the field and is better for human health and safety. Green chemistry emphasizes that the solvent should be nontoxic, safe, cheap, green, readily available, recyclable, and biodegradable. Deep eutectic solvents, a new type of green solvent, have some renowned properties—for instance, high thermal stability, low vapor pressure, low cost, biodegradability, and high viscosity. In this study, deep eutectic solvents made up of choline chloride-glycerol (1:2) were used for the extraction and isolation of flavonoid (rutin, gallic acid, and quercetin) from Catharanthus roseus plant parts, flower petal, leaves, stem, and root. The amounts of rutin and quercetin in flower petal are 29.46 and 6.51%, respectively, whereas, rutin, gallic acid, and quercetin amounts in leaves are 25.16, 8.57, and 10.47%, respectively. In stem the amounts of rutin, gallic acid, and quercetin are 13.02, 5.89, and 7.47%, respectively. In root, only quercetin has been obtained that is 13.49%. The HPLC is an analytical method, which was found to be an excellent technique for determination of rutin, gallic acid, and quercetin using deep eutectic solvent extraction from plant parts of Catharanthus roseus.

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Green extraction of five target phenolic acids from Lonicerae japonicae Flos with deep eutectic solvent

Cited by 182 publications

References 24 publications

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

Deep eutectic solvent‐based extraction of polyphenolic antioxidants from onion (Allium cepa L.) peel

Antioxidant and Total Phenolic Content of Catharanthus roseus Using Deep Eutectic Solvent

Identification of Flavonoids (Quercetin, Gallic acid and Rutin) from Catharanthus roseus Plant Parts using Deep Eutectic Solvent

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