2019
DOI: 10.3390/ijms20133139
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Green Fluorescent Terbium (III) Complex Doped Silica Nanoparticles for TSPO Targeting

Abstract: The low photostability of conventional organic dyes and the toxicity of cadmium-based luminescent quantum dots have prompted the development of novel probes for in vitro and in vivo labelling. Here, a new fluorescent lanthanide probe based on silica nanoparticles is fabricated and investigated for optically traceable in vitro translocator protein (TSPO) targeting. The targeting and detection of TSPO receptor, overexpressed in several pathological states, including neurodegenerative diseases and cancers, may pr… Show more

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Cited by 18 publications
(8 citation statements)
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“…At this point, both the nucleation and the growth of silica on the SPIONs take place in the aqueous droplets, which act as nanoreactors, thus defining the final size and shape of the silica‐based NPs. As previously reported, the relative Igepal/ammonia molar ratio determines the number and size of the reverse micelles . Therefore, it can be reasonably assumed that, when the number of SPIONs matches the number of micelles, most of the micelles would be occupied by one SPION, resulting in core–shell nanostructures.…”
Section: Resultsmentioning
confidence: 76%
See 1 more Smart Citation
“…At this point, both the nucleation and the growth of silica on the SPIONs take place in the aqueous droplets, which act as nanoreactors, thus defining the final size and shape of the silica‐based NPs. As previously reported, the relative Igepal/ammonia molar ratio determines the number and size of the reverse micelles . Therefore, it can be reasonably assumed that, when the number of SPIONs matches the number of micelles, most of the micelles would be occupied by one SPION, resulting in core–shell nanostructures.…”
Section: Resultsmentioning
confidence: 76%
“…The silica shell coating the OLEAM‐capped SPIONs was grown by exploiting a water‐in‐oil microemulsion approach, to obtain superparamagnetic nanostructures with a good degree of biocompatibility and colloidal stability in aqueous media . In particular, appropriate amounts of Igepal CA‐630, ammonia aqueous solution and TEOS were added, at 28 °C, in a cyclohexane dispersion of OLEAM capped SPIONs.…”
Section: Resultsmentioning
confidence: 99%
“…Repeated cycles of NP dispersion in ethanol and centrifugation were carried out to completely remove surfactant residuals and to finally collect NPs, finally dispersed in 2 mL of ethanol. The effective characterization and quantitative analysis of primary amino groups in a different type of systems [43], was carried out by a ninhydrin assay. A ninhydrin solution was prepared by dissolving 110 mg of ninhydrin in 16 mL of ethanol (0.68% w/v) and adding 4 mL of 2,6 lutidine.…”
Section: Methodsmentioning
confidence: 99%
“…This solution has the advantage of synthetic simplicity, but it brings in some undesired issues: (1) only cavitands on the particles surface are active in BTEX uptake as most of them are buried in the bulk solid; (2) cavitands are randomly oriented, and only those with the mouth of the cavity exposed can trap the analytes; and (3) the cavitand particles tend to become smaller and smaller by mechanical stress due to flow pumping while cycling at high temperature, causing a progressive increase in MEMS impedance and a consequent loss of performance. These issues prompted us to consider the grafting of QxCav on solid supports as a workable solution [12,13].…”
Section: Introductionmentioning
confidence: 99%