Green Nanotechnology-Driven Drug Delivery Assemblies

Kanwar, Rohini; Rathee, Jyoti; Salunke, Deepak B.; Mehta, Surinder Kumar

doi:10.1021/acsomega.9b00304

Cited by 115 publications

(48 citation statements)

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“…PI is a stabilizing agent and reservoir for triiodide anions releasing free molecular iodine for biocidal action [32,48]. AgNP is a drug carrier and adsorbs TCA, Cinn, and PI on its large surface [57,60]. TCA, Cinn, and PI as stabilizing agents prevent agglomeration of silver, resulting in smaller AgNPs and better microbial growth control.…”

Section: Introductionmentioning

confidence: 99%

“…A promising development is the combination of PVP with iodine nanoparticles and its incorporation into wound dressing materials to inhibit bacteria and biofilm formation which may reduce the above adverse effects due to minimizing the iodine content [31,48].Nanotechnology offers a wide range of medical applications including biodegradable, plant and polymer-based antimicrobial compounds [51][52][53][54][55][56]. Nanomedicine includes organic and inorganic drug delivery systems, ensuring long shelf life with reduced drug loss and low toxicity [15,57].…”

mentioning

confidence: 99%

“…Nanotechnology offers a wide range of medical applications including biodegradable, plant and polymer-based antimicrobial compounds [51][52][53][54][55][56]. Nanomedicine includes organic and inorganic drug delivery systems, ensuring long shelf life with reduced drug loss and low toxicity [15,57].…”

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confidence: 99%

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“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

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“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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“…Incidence of hospital-acquired infections was directly related to hospitalization time and nosocomial infection by multidrug-resistant pathogens, with Acetinobacter baumanii as the most common strain isolated from the lower respiratory tract [60]. Nanotechnology is delivering promising future perspectives to develop vaccines and solutions against antibiotic resistance [61][62][63][64][65][66]. Jorquera et al reported on nanovaccines against the respiratory syncytial virus [64].…”

Section: Role Of Basic Sciences Against Covid-19 and Antibiotic Resismentioning

confidence: 99%

Prevalence of COVID-19: A Look behind the Scenes from the UAE and India

Bloukh¹,

Shaikh²,

Pathan³

et al. 2020

Preprint

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Mankind faces a coronavirus pandemic originating from a seafood market in Wuhan, China since December 2019. The pathogen was named novel coronavirus (n-CoV) and bats are the identified key reservoir. The coronavirus disease 2019 (COVID-19) quickly spread over China across the globe, turned into a pandemic with exponentially increasing numbers of cases and significant mortality rate. China reacted with lockdowns and strict control measurements to prevent spreading the virus. The treatment of severe cases was hampered by lack of specific vaccines. Vaccine-development and production is a painstaking process and can only be enforced by international cooperation. Different supportive treatment options surfaced due to combinations of antiviral agents with antibiotic drugs. Elderly, male, immune-suppressed patients with co-morbidities showed a high mortality rate. Health literacy, strong immune system, adequate serum 25-hydroxyvitamin D (25(OH)D) concentrations and healthy life style choices can support fast recovery. Antibiotic resistance needs to be addressed by development of new generation antimicrobials against nosocomial infections in preparation for future outbreaks. Plant-biosynthesis of nanomaterials and antiseptics may help in prevention and recovery rate. Prevalence of COVID-19 maybe inversely related to BCG vaccination, endemicity of malaria, humidy and temperature but directly with latitude. Recommendations to prevent the spread of COVID-19 should be followed strictly.

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“…lipids, biopolymers, proteins) is quite common. 3 Low sustainability of delivery carriers production stimulates scientists to think about the possible negative environmental impact that the global production of delivery vehicles may have. 4 In view of the above, the quest for alternatives sources for drug delivery vehicles -minerals, bacteria and waste materialsresulted in the rise of a new wave of drug delivery research.…”

Section: Introductionmentioning

confidence: 99%