Green synthesis, characterization and in vitro release of cinnamaldehyde/sodium alginate/chitosan nanoparticles

Ji, Mingyu; Sun, Xinyu; Guo, Xiaoting; Zhu, Wenjin; Wu, Jiulin; Chen, Li; Wang, Jianhua; Chen, Mingmao; Cheng, Cui; Zhang, Qiqing

doi:10.1016/j.foodhyd.2018.12.027

Cited by 81 publications

(41 citation statements)

References 32 publications

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“…An intense peak was observed at 23°indicating the presence of the Cs-Al NDs, which can be inferred that alginate is influencing the crystalline properties of chitosan through hydrogen bonding, and electrostatic interaction between negative and positive charges, confirming the formation of a polyelectrolyte complex using the ionic gelation method [14,23,42]. These results are in agreement with those reported in the literature, allowing to state that the Cs-Al NDs present high crystallinity, strong electrostatic International Journal of Polymer Science interaction, and good order of the crystallites [19]. The crystallite size for the Cs-Al NDs was calculated to be 1.6 nm from the peak with the strongest intensity at 23°, according to the following Debye-Scherrer equation (1):…”

Section: Resultssupporting

confidence: 90%

“…Scanning electron microscopy (SEM) images shown in Figures 1(a) and 1(b) determine the morphological features of the as-synthesized Cs-Al NDs. Agglomeration can be observed since the nanodisks were lyophilized previously, but the shape of the disks can still be seen clearly as shown in the SEM image in Figure 1(b) [19]. The nanoparticles were successfully synthesized with a more disk shape than the usual spherical or common structures, presenting a regular and smooth surface but a wide size range, which can be attributed to many factors such as the biopolymer concentrations and electrostatic interaction that occurs during ionotropic gelation using sodium tripolyphosphate (STPP) as a highly charged compound [20,21].…”

Section: Resultsmentioning

confidence: 92%

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Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Patiño-Ruiz

Marrugo

Reyes

et al. 2020

International Journal of Polymer Science

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We report on the synthesis of chitosan-alginate nanodisks (Cs-Al NDs) using a simple approach consisting of the ionotropic gelation method. Sodium tripolyphosphate (STPP) was used as crosslinking agent to promote the electrostatic interaction between amine groups the chitosan and hydroxyl and carboxyl groups of alginate. Scanning electron microscopy (SEM) images provided direct evidence of the morphology of the nanodisks where agglomeration was observed due to the electrostatic interaction between the functional groups. Furthermore, dynamic light scattering (DLS) showed that the hydrodynamic size of the Cs-Al NDs was 227 nm and 152 nm in pH 1.2 and pH 7.4, respectively, which is in agreement with the information observed in the SEM images. The chemical structure is presented mainly the amine and carboxyl groups due to the presence of chitosan and alginate in the nanodisks, respectively, which allow the electrostatic interaction through N-H linkages. According to the X-ray diffraction, we found that the Cs-Al NDs exhibited the typical structure of chitosan and alginate, which lead the formation of polyelectrolyte complexes. We also evaluated the encapsulation of amoxicillin in the nanodisk, obtaining a loading efficiency of 74.98%, as well as a maximum in vitro release amount of 63.2 and 52.3% at pH 1.2 and 7.4, respectively. Finally, the cytotoxicity effect of the Cs-Al nanodisks was performed in human prostatic epithelial PWR-1E and Caucasian prostate adenocarcinoma PC-3 cell lines, in which the cell viability was above 80% indicating low inhibition and determining the Cs-Al NDs as a promising technology for controlled delivery systems.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 92%

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Patiño-Ruiz

Marrugo

Reyes

et al. 2020

International Journal of Polymer Science

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“…The IR spectrum of both biopolymers can be assigned by analogy to the literature. 50,51 FTIR analysis of the hybrid-beads (non-calcined samples) indicated the appearance of the characteristic peaks of the biopolymers used with slight modications (enhanced intensities) related to cross-linking biopolymer. It must be emphasized that an additional peak at 1733 cm À1 was observed in all hybrid materials, attributed to carbonyl stretching (-C]O group).…”

Section: Resultsmentioning

confidence: 99%

Controlling the growth of nanosized titaniaviapolymer gelation for photocatalytic applications

et al. 2020

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“…DLS provides a hydrodynamic size and is more quantitative, while AFM and TEM offer both qualitative and quantitative information such as particle shape, surface morphology, and size of the NPs. Similarly, structural changes in the formation of ChNPs were reportedly observed employing TEM, AFM, SEM, Fourier-transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRD) [72,73,74,75,76].…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles

Rizeq

Younes

Rasool

et al. 2019

IJMS

229

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The development of advanced nanomaterials and technologies is essential in biomedical engineering to improve the quality of life. Chitosan-based nanomaterials are on the forefront and attract wide interest due to their versatile physicochemical characteristics such as biodegradability, biocompatibility, and non-toxicity, which play a promising role in biological applications. Chitosan and its derivatives are employed in several applications including pharmaceuticals and biomedical engineering. This article presents a comprehensive overview of recent advances in chitosan derivatives and nanoparticle synthesis, as well as emerging applications in medicine, tissue engineering, drug delivery, gene therapy, and cancer therapy. In addition to the applications, we critically review the main concerns and mitigation strategies related to chitosan bactericidal properties, toxicity/safety using tissue cultures and animal models, and also their potential environmental impact. At the end of this review, we also provide some of future directions and conclusions that are important for expanding the field of biomedical applications of the chitosan nanoparticles.

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Green synthesis, characterization and in vitro release of cinnamaldehyde/sodium alginate/chitosan nanoparticles

Cited by 81 publications

References 32 publications

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Ionotropic Gelation Synthesis of Chitosan-Alginate Nanodisks for Delivery System and In Vitro Assessment of Prostate Cancer Cytotoxicity

Controlling the growth of nanosized titaniaviapolymer gelation for photocatalytic applications

Synthesis, Bioapplications, and Toxicity Evaluation of Chitosan-Based Nanoparticles

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