Green Synthesis of Bifunctional Fluorescent Carbon Dots from Garlic for Cellular Imaging and Free Radical Scavenging

Zhao, Shaojing; Lan, Minhuan; Zhu, Xiaoyue; Han, Xue; Ng, Tsz‐Wai; Meng, Xiangmin; Lee, Chun‐Sing; Wang, Pengfei; Zhang, Wenjun

doi:10.1021/acsami.5b03228

Cited by 554 publications

(266 citation statements)

References 59 publications

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“…This result coincides with previous reports that CQDs were able to stain both the cytoplasm and cell membrane but it was difficult to label the nucleus. 5 Thus, the CQDs were suggested to be internalized into the cells through endocytosis, similar to other CQDs reported previously. 19 Besides, it was found that the fluorescence …”

Section: Bioimaging Applicationssupporting

confidence: 83%

“…4 Among them, hydrothermal treatment of natural precursors is a low-cost and convenient route to prepare CQDs. [5][6][7][8][9] However, most reported CQDs have a relatively low fluorescence quantum yield in comparison to inorganic semiconductor quantum dots. [10][11][12][13] To improve the fluorescent properties of CQDs, two kinds of modifications including surface functionalization and heteroatom doping were proposed.…”

Section: Introductionmentioning

confidence: 99%

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Facile synthesis of N-rich carbon quantum dots from porphyrins as efficient probes for bioimaging and biosensing in living cells

Wang

et al. 2017

IJN

159

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N-rich metal-free and metal-doped carbon quantum dots (CQDs) have been prepared through one-step hydrothermal method using tetraphenylporphyrin or its transition metal (Pd or Pt) complex as precursor. The structures and morphology of the as-prepared nanoparticles were analyzed by X-ray diffraction, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, and Fourier transform infrared spectra. Three kinds of nanocomposites show similar structures except for the presence of metal ions in Pd-CQDs and Pt-CQDs indicated by X-ray photoelectron spectroscopy. All of them display bright blue emission upon exposure to ultraviolet irradiation. The CQDs exhibit typical excitation-dependent emission behavior, with the emission quantum yield of 10.1%, 17.8%, and 15.2% for CQDs, Pd-CQDs, and Pt-CQDs, respectively. Moreover, the CQDs, Pd-CQDs, and Pt-CQDs could serve as fluorescent probes for the specific and sensitive detection of Fe 3+ ions in aqueous solution. The low cytotoxicity of CQDs is demonstrated by MTT assay against HeLa cells. Therefore, the CQDs can be used as efficient probes for cellular multicolor imaging and fluorescence sensors for the detection of Fe 3+ ions due to their low toxicity, excellent biocompatibility, and low detection limits. This work provides a new route to synthesize highly luminescent N-rich metal-free or metal-doped CQDs for multifunctional applications.

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Section: Bioimaging Applicationssupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Facile synthesis of N-rich carbon quantum dots from porphyrins as efficient probes for bioimaging and biosensing in living cells

Wang

et al. 2017

IJN

159

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“…Many CD syntheses report the use of biomass, particularly sourced from plant matter, which is essentially a huge source of naturally derived polysaccharides combined with smaller amounts of other organic molecules, e.g., amino acids, which can act as dopant agents. Some examples include the use of garlic [50], orange juice [51], onion waste [52] and general kitchen waste [53]. For the purpose of this review, we will concentrate on describing examples where defined and commercially available polysaccharides are used for the synthesis of FCDs and how these materials compare to CDs made using their monomeric counterparts.…”

Section: Reviewmentioning

confidence: 99%

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

Hill¹,

Galan²

2017

Beilstein J. Org. Chem.

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Fluorescent carbon dots (FCDs) are an emerging class of nanomaterials made from carbon sources that have been hailed as potential non-toxic replacements to traditional semiconductor quantum dots (QDs). Particularly in the areas of live imaging and drug delivery, due to their water solubility, low toxicity and photo-and chemical stability. Carbohydrates are readily available chiral biomolecules in nature which offer an attractive and cheap starting material from which to synthesise FCDs with distinct features and interesting applications. This mini-review article will cover the progress in the development of FCDs prepared from carbohydrate sources with an emphasis on their synthesis, functionalization and technical applications, including discussions on current challenges. 675

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“…Many CDs manufacturing methods have been developed, including pyrolysis 26 , hydrothermal 27 , calcination 28 , microwave assisted 29 , and laser-assisted 30 . Various raw materials have been adopted for the preparation of quantum dots, including glucose 31 , garlic 32 , wool 8 , candle soot 33 , and graphite 34 . This range of materials and techniques suggests that restrictions on what can be used for quantum dot production are limited only by the imagination.…”

Section: Discussionmentioning

confidence: 99%

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

Zhao

Zhang

Liu

et al. 2017

Sci Rep

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In this study, the properties of egg yolk oil (EYO) were investigated. Water extraction, dialysis, and ultrafiltration were used to extract and purify EYO, and microscopy, spectrophotometry, and chromatography were used to identify carbon dots (CDs) present in EYO (EYO CDs). Morphology analyses demonstrated that CDs were almost spherical, with an average size of <10 nm, a lattice spacing of 0.267 nm, and a composition of mainly C, O, and Fe. The solution showed bright blue fluorescence at 365 nm. Tail haemorrhaging and liver haemorrhaging experiments showed that CD-treated mice had significantly shorter bleeding times than did control mice. Coagulation assays suggested that EYO CDs stimulate the intrinsic blood coagulation system and activate the fibrinogen system. Thus, EYO CDs possess the ability to activate haemostasis, which may lead to further investigations of this ingredient of traditional Chinese medicine.

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Green Synthesis of Bifunctional Fluorescent Carbon Dots from Garlic for Cellular Imaging and Free Radical Scavenging

Cited by 554 publications

References 59 publications

Facile synthesis of N-rich carbon quantum dots from porphyrins as efficient probes for bioimaging and biosensing in living cells

Facile synthesis of N-rich carbon quantum dots from porphyrins as efficient probes for bioimaging and biosensing in living cells

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

Novel carbon quantum dots from egg yolk oil and their haemostatic effects

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