Green synthesis of copper nanoparticles from an extract of<i>Jatropha curcas</i>leaves: characterization, optical properties, CT-DNA binding and photocatalytic activity

Ghosh, Mithun Kumar; Sahu, S. K.; Gupta, Indersh; Ghorai, Tanmay Kumar

doi:10.1039/d0ra03186k

Cited by 122 publications

(47 citation statements)

References 38 publications

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“…An Ultraviolet-Visible spectrum is used to analyse the Surface Plasmon Resonance (SPR) of nanoparticles. The UV-Visible spectra for CuNPs were in the range of 250 nm-360 nm [38,39]. Likewise, our CuNPs synthesized using Wt R.Br showed absorption peak maxima at 357 nm in the UV-Visible spectra (Figure 3).…”

Section: Uv-visible Spectral Analysismentioning

confidence: 56%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

Heliyon

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The synthesis of copper nanoparticles (CuNPs) using Wrightia tinctoria (Wt) R.Br extract is defined in this article as being convenient, environmentally friendly, and non-toxic. UV-visible spectrophotometry, FT-IR, XRD, particle size analyser, SEM-EDAX and TEM methods were used to describe the physicochemical properties of Wt extract mediated synthesized CuNPs (Wt-CuNPs). The Wt-CuNPs synthesized was found to be monodispersed and spherical, with an average size of 15 nm. Gas chromatography and mass spectrometry (GC-MS) research revealed that the Wt R.Br plant extract contains various phytochemical compounds. The properties of Wt-CuNPs were verified by the findings of characterization tests. Via in silico molecular docking experiments with established targets, the underlying mechanisms of cytotoxicity against breast cancer and larvicidal behaviour against Aedes aegypti of Wt-CuNPs were investigated. Interestingly, in vitro cytotoxicity studies showed 50% cell death (IC 50 ) of Wt-CuNPs treated MCF-7 cells and Vero Cells (Kidney epithelial cells) were displayed at 119.23 μg.mL À1 and 898.75 μg.mL À1 , respectively. Also, Wt-CuNPs showed least LC 50 and LC 90 values for larvicidal activity against A. aegypti were of 32.10 μg.mL À1 and 21.70 μg.mL À1 , respectively. Furthermore, Wt-CuNPs is found to be less toxic and biocompatible in haemolytic assays. The findings clearly showed that biosynthesized Wt-CuNPs have been used as a possible anticancer and larvicidal agent, as well as being environmentally friendly.

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Section: Uv-visible Spectral Analysismentioning

confidence: 56%

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Rajagopal¹,

Nivetha

Sundar³

et al. 2021

Heliyon

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“…UV-Vis absorption spectrophotometry is a useful technique to investigate the interaction between anticancer drug molecules and DNA [ 23 , 24 , 25 ]. Therefore, we investigated the potential of LNEO as an anticancer drug molecule using UV-Vis absorption spectrophotometry.…”

Section: Resultsmentioning

confidence: 99%

Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment

et al. 2022

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The aim of this study was to obtain essential oil (LNEO) from the Laurus nobilis L. plant, and to prepare LNEO-loaded poly lactic-co-glycolic acid (PLGA) nanoparticles (NPs) as an approach in cancer treatment. The components of the obtained LNEO were analyzed using GC-MS. The LNEO-NPs were synthesized by the single-emulsion method. The LNEO-NPs were characterized using UV-Vis spectrometry, Dynamic Light Scattering (DLS), Scanning Electron Microscopy (SEM), and a DNA binding assay, which was performed via the UV-Vis titration method. According to the results, the LNEO-NPs had a 211.4 ± 4.031 nm average particle size, 0.068 ± 0.016 PdI, and −7.87 ± 1.15 mV zeta potential. The encapsulation efficiency and loading capacity were calculated as 59.25% and 25.65%, respectively, and the in vitro drug release study showed an LNEO release of 93.97 ± 3.78% over the 72 h period. Moreover, the LNEO was intercalatively bound to CT-DNA. In addition, the mechanism of action of LNEO on a dual PI3K/mTOR inhibitor was predicted, and its antiproliferative activity and mechanism were determined using molecular docking analysis. It was concluded that LNEO-loaded PLGA NPs may be used for cancer treatment as a novel phytotherapeutic agent-based controlled-release system.

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“…Metal-based nanomaterials, including copper nanoparticles (CuNPs), iron (FeNPs), palladium (PtNPs), gold (AuNPs), aluminum (AlNPs), zinc (ZnNPs) and silver (AgNPs), are typically synthesized naturally or synthetically [1,2]. Gold nanoparticles are one of the most significant ones as it has several therapeutic applications [3,4] such as drug delivery system for several diseases such as cancer diagnosis and therapy [5], radiosensitizers [6], biosensors [7], bio-sensing [8], bio-imaging and environmental applications of dye degradation [9], bioremediation of toxic chemicals present in the environment [10] and muscle tissue engineering [11].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Phoma sp. Biomass as an Endophytic Fungus for Synthesis of Extracellular Gold Nanoparticles with Antibacterial and Antifungal Properties

et al. 2022

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The aim of our study was to examine the different concentrations of AuNPs as a new antimicrobial substance to control the pathogenic activity. The extracellular synthesis of AuNPs performed by using Phoma sp. as an endophytic fungus. Endophytic fungus was isolated from vascular tissue of peach trees (Prunus persica) from Baft, located in Kerman province, Iran. The UltraViolet-Visible Spectroscopy (UV–Vis spectroscopy) and Fourier transform infrared spectroscopy provided the absorbance peak at 526 nm, while the X-ray diffraction and transmission electron microscopy images released the formation of spherical AuNPs with sizes in the range of 10–100 nm. The findings of inhibition zone test of Au nanoparticles (AuNPs) showed a desirable antifungal and antibacterial activity against phytopathogens including Rhizoctonia solani AG1-IA (AG1-IA has been identified as the dominant anastomosis group) and Xanthomonas oryzae pv. oryzae. The highest inhibition level against sclerotia formation was 93% for AuNPs at a concentration of 80 μg/mL. Application of endophytic fungus biomass for synthesis of AuNPs is relatively inexpensive, single step and environmentally friendly. In vitro study of the antifungal activity of AuNPs at concentrations of 10, 20, 40 and 80 μg/mL was conducted against rice fungal pathogen R. solani to reduce sclerotia formation. The experimental data revealed that the Inhibition rate (RH) for sclerotia formation was (15, 33, 74 and 93%), respectively, for their corresponding AuNPs concentrations (10, 20, 40 and 80 μg/mL). Our findings obviously indicated that the RH strongly depend on AuNPs rates, and enhance upon an increase in AuNPs rates. The application of endophytic fungi biomass for green synthesis is our future goal.

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Green synthesis of copper nanoparticles from an extract ofJatropha curcasleaves: characterization, optical properties, CT-DNA binding and photocatalytic activity

Abstract: The green synthesis of copper nanoparticles (CuNPs) using a leaf extract from Jatropha curcas (JC) has been documented in our present research work.

Cited by 122 publications

References 38 publications

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Mixed phytochemicals mediated synthesis of copper nanoparticles for anticancer and larvicidal applications

Laurus nobilis L. Essential Oil-Loaded PLGA as a Nanoformulation Candidate for Cancer Treatment

Evaluation of Phoma sp. Biomass as an Endophytic Fungus for Synthesis of Extracellular Gold Nanoparticles with Antibacterial and Antifungal Properties

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