Green tea and type 2 diabetes

Abstract

Green tea and coffee consumption have been widely popular worldwide. These beverages contain caffeine to activate the central nervous system by adenosine receptor blockade, and due to the caffeine, addiction or tolerance may occur. In addition to this caffeine effect, green tea and coffee consumption have always been at the center of discussions about human health, disease, and longevity. In particular, green tea catechins are involved in many biological activities such as antioxidation and modulation of various cellular lipid and proteins. Thus, they are beneficial against degenerative diseases, including obesity, cancer, cardiovascular diseases, and various inflammatory diseases. Some reports also suggest that daily consumption of tea catechins may help in controlling type 2 diabetes. However, other studies have reported that chronic consumption of green tea may result in hepatic failure, neuronal damage, and exacerbation of diabetes, suggesting that interindividual variations in the green tea effect are large. This review will focus on the effect of green tea catechins extracted from the Camellia sinensis plant on type 2 diabetes and obesity, and the possible mechanistic explanation for the experimental results mainly from our laboratory. It is hoped that green tea can be consumed in a suitable manner as a supplement to prevent the development of type 2 diabetes and obesity.

Effects of alternative steeping methods on composition, antioxidant property and colour of green, black and oolong tea infusions

“…According to processing, such as extent of oxidation (so-called Bfermentation^), three types of tea are known: green (non-fermented), oolong (semifermented) and black tea (fully fermented). Black tea is the most consumed in Western countries, although great attention has been paid in recent years to green tea, for its higher antioxidant activity and related health effects (Steinmann et al 2013;Park et al 2014;Pang et al 2015).…”

Development and validation of a high‐throughput assay for the quantification of multiple green tea‐derived catechins in human plasma

“…Catechins have been suggested to have preventative effects against a large number of chronic diseases and conditions including atherosclerosis (Miura et al, 2001), diabetes (Park, Bae, Im, & Song, 2014), cancer (Maruyama et al, 2014;Yang et al, 2011) and obesity (Grove & Lambert, 2010). The precise biological mechanisms by which catechins achieve these benefits are not clear and have been hypothesized to arise from a variety of sources including antioxidant properties and prooxidant properties (Lambert & Elias, 2010;León-González, Auger, & Schini-Kerth, 2015;Lorenzo & Munekata, 2016).…”

Kajian Potensi Kayu Manis dan Teh sebagai Pangan Antidiabetes

“…Diabetes (Rafehi et al, 2012) Mekanisme kerja dari EGCG teh hijau dalam penanganan diabetes seperti yang terlihat pada Gambar 6 dapat melalui beberapa jalur yaitu: (1) menurunkan aktivitas enzim pencernaan, (2) menurunkan aktivitas GLUT usus terutama sodium-dependent glucose transporter1 (SGLT1), (3) menurunkan ekspresi gen enzim glukoneogenesis, (4) meningkatkan sensitivitas insulin, (5) meningkatkan aktivitas insulin mimetic, (6) merubah status reaksi redoks, (7) meningkatkan pertahanan pada hati, sel beta pankreas, dan sel lainnya, dan (8) menurunkan massa adipose, resistin dan lemak darah (Kao et al2006). Park et al (2014) menyatakan bahwa mekanisme molekuler senyawa katekin dalam penanganan DMT2 tergantung dari konsentrasi, jenis, dan struktur katekin. Katekin dapat menghambat SGLT1 dan GLUT dengan konsentrasi yang sangat rendah yaitu kurang dari 1 µM sedangkan untuk menghambat penyerapan alcohol dibutuhkan konsentrasi lebih dari 100 µM.…”