Green tea protects against ethanol-induced lipid peroxidation in rat organs

Ostrowska, Justyna; Łuczaj, Wojciech; Kasacka, Irena; Różański, Andrzej; Skrzydlewska, Elżbieta

doi:10.1016/j.alcohol.2003.11.001

Cited by 81 publications

(39 citation statements)

References 39 publications

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“…Scavenging and protective activities of green tea polyphenols [8], preventive effect of green tea catechins on experimental tumor metastasis [9], protective effect of green tea on ethanol-induced lipid peroxidation [10] and tamoxifen-induced liver injury [11] have been reported. Catechins have beneficial effects in prevention of cardiovascular diseases including LDL oxidative susceptibility [12].…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

et al. 2010

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Objective of this study was to obtain a better understanding of the mechanism responsible for the d-galactosamine (d-GalN) induced hepatotoxicity and to study the effect of catechin against d-GalN induced hepatotoxicity. Catechin 50 and 100 mg/kg b.wt was administered for 1 week by oral route. Liver damage was induced by intra-peritoneal administration of 400 mg/kg b.wt d-galactosamine on the last day of catechin treatment. At the end of treatment all animals were killed and liver enzyme levels were estimated. Dissected hepatic samples were used for histopathology, RNA isolation, expression studies of Bax, Bcl-2 and p53 mRNA levels and mitochondrial membrane potential studies. We found that increases in the liver enzyme activity and decrease in antioxidant enzyme activity by d-GalN were significantly restricted by oral pretreatment with catechin. Disruption of mitochondrial membrane potential, up regulation of p53, Bax and down regulation of Bcl-2 mRNA levels in the liver of d-GalN intoxicated rats were effectively prevented by pretreatment with catechin.

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Section: Introductionmentioning

confidence: 99%

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

et al. 2010

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“…Ethanol consumption primarily manifests its harmful teratogenic effects by promoting oxidative damage, and the liver is a major site of ethanol-induced oxidative damage (Ostrowska, quczaj, Kasacka, Róza nski, & Skrzydlewska, 2004). In this context, the aims of this paper are to measure the effect of prenatal and early postnatal ethanol exposure on the levels of the main hepatic selenoproteins GPx1, GPx4, and SelP, and to study the effects of the altered selenoprotein levels on biological processes.…”

Section: Introductionmentioning

confidence: 99%

Selenium dietary supplementation as a mechanism to restore hepatic selenoprotein regulation in rat pups exposed to alcohol

Jotty

Ojeda

Nogales

et al. 2013

Alcohol

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“…In many cases, this effect may manifest itself around dead cells. In a similar study, it was found by EM that there were morphological changes, indicating disorders in the membranes of the liver parenchymal cells of rats exposed to alcohol (Ostrowskaa et al, 2004).…”

Section: Discussionmentioning

confidence: 69%

Consumption ofCoprinus comatuspolysaccharide extract causes recovery of alcoholic liver damage in rats

Ozalp

Canbek

Yamaç

et al. 2014

Pharmaceutical Biology

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Context: Excess use of alcohol is known to be associated with liver diseases such as fatty liver, alcoholic hepatitis, and cirrhosis. Various practices may be applied to prevent or treat the damage caused by chronic alcoholism. Coprinus comatus (O.F. Mü ll.) Pers. (Agaricaceae) is a macrofungus that has been reported to aid the recovery of murine livers damaged by benzopyrene. Objective: In this study, the possible therapeutic effects of three different doses (50, 100, and 150 mg/kg) of C. comatus polysaccharide (PS) extract were studied in rats subjected to an alcoholic diet. The histological and biochemical results were compared between the control and experimental groups. Materials and methods: Modified Lieber-Decarli's calorie-adjusted liquid alcohol diet was given orally for 60 d. In addition to histopathology, alanine transaminase (ALT), aspartate transaminase (AST), mitochondrial membrane integrity, total cytochrome-c oxidase activity (TotalStCox), total mitochondrial cytochrome-c oxidase activity (TotalMtStCox), and caspase-3 values were used as liver parameters, and liver sections from all experimental groups were examined by electron microscopy. Results: Using histopathological assessment, it was observed that there was a decline in liver hepatocyte vacuolization in the treatment group fed 50 mg PS/kg. The TotalStCox and TotalMtStCox values of this group differed from the EtOH control group (p50.05). Discussion and conclusion: Daily administration of 50 mg/kg of C. comatus PS extract considerably reduced the negative effects of alcohol on liver structure and function.

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Green tea protects against ethanol-induced lipid peroxidation in rat organs

Cited by 81 publications

References 39 publications

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

Protective Role of Catechin on d-Galactosamine Induced Hepatotoxicity Through a p53 Dependent Pathway

Selenium dietary supplementation as a mechanism to restore hepatic selenoprotein regulation in rat pups exposed to alcohol

Consumption ofCoprinus comatuspolysaccharide extract causes recovery of alcoholic liver damage in rats

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