Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb

Panhard, S.; Lozano, I.; Loussouarn, G.

doi:10.1111/j.1365-2133.2012.11095.x

Cited by 101 publications

(97 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is often quoted that as a rule of thumb, 50% of people are 50% gray by the age of 50 [28]. Recent epidemiologic studies of men and women of various races suggests a far lower number-only 6-23% of people have 50% gray hair at age 50 [34]. People of Asian and African descent showed less gray hair than those of Caucasian origin [34].…”

Section: Hair Grayingmentioning

confidence: 99%

See 1 more Smart Citation

Age-related hair changes in men: Mechanisms and management of alopecia and graying

Mirmirani

2015

Maturitas

View full text Add to dashboard Cite

Section: Hair Grayingmentioning

confidence: 99%

“…Recent epidemiologic studies of men and women of various races suggests a far lower number-only 6-23% of people have 50% gray hair at age 50 [34]. People of Asian and African descent showed less gray hair than those of Caucasian origin [34]. The age of onset of hair graying is also influenced by genetics.…”

Section: Hair Grayingmentioning

confidence: 99%

Age-related hair changes in men: Mechanisms and management of alopecia and graying

Mirmirani

2015

Maturitas

View full text Add to dashboard Cite

“…Spelled 'grey' by the British, and 'gray' by the Americans, it is defined as the change in hair colour that makes us feel older. While inaccurate, the commonly believed 'Rule of 50' (50% of 50-year-olds have about 50% grey hairs) [1] clearly emphasizes the mutual concern of our society in regards to hair greying.…”

Section: Introductionmentioning

confidence: 99%

Age‐induced hair greying – the multiple effects of oxidative stress

Seiberg¹

2013

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

SynopsisAn obvious sign of ageing is hair greying, or the loss of pigment production and deposition within the hair shafts. Numerous mechanisms, acting at different levels and follicular locations, contribute to hair greying, ranging from melanocyte stem cells defects to follicular melanocyte death. One key issue that is in common to these processes is oxidative damage. At the hair follicle stem cells niche, oxidative stress, accelerated by B-cell lymphoma 2 gene (BCL-2) depletion, leads to selective apoptosis and diminution of melanocyte stem cells, reducing the repopulation of newly formed anagen follicles. Melanotic bulbar melanocytes express high levels of BCL-2 to enable survival from melanogenesis-and ultraviolet A (UVA)-induced reactive oxygen species (ROS) attacks. With ageing, the bulbar melanocyte expression of anti-oxidant proteins such as BCL-2, and possibly TRP-2, is reduced, and the dedicated enzymatic anti-oxidant defence system throughout the follicle weakens, resulting in enhanced oxidative stress. A marked reduction in catalase expression and activity results in millimolar accumulation of hydrogen peroxide, contributing to bulbar melanocyte malfunction and death. Interestingly, amelanotic melanocytes at the outer root sheath (ORS) are somewhat less affected by these processes and survive for longer time even within the white, ageing hair follicles. Better understanding of the overtime susceptibility of melanocytes to oxidative stress at the different follicular locations might yield clues to possible therapies for the prevention and reversal of hair greying.R esum e Un signe evident du vieillissement est le grisonnement des cheveux ou la perte de la production de pigment et de son d epôt dans les follicules pileux. De nombreux m ecanismes, agissant a diff erents niveaux et endroits folliculaires, contribuent aux cheveux grisonnants, allant des dommages aux cellules souches m elanocytaires a la mort des m elanocytes folliculaires. Une question cl e qui est commune a ces processus concerne le dommage oxydatif. Au niveau de la niche des cellules souches du follicule, le stress oxydatif, acc el er e par l'appauvrissement de BCL-2, conduit a l'apoptose et a une diminution s elective des cellules souches des m elanocytes, ce qui r eduit le repeuplement des follicules anag enes nouvellement form es. Les m elanocytes bulbaires m elaniques expriment des niveaux elev es de Bcl-2 pour permettre la survie suite a l'attaque par les esp eces r eactives de l'oxyg ene (ROS) induites par la m elanog en ese et les ultraviolets A (UVA). Avec le vieillissement, l'expression dans m elanocytes du bulbe des prot eines anti-oxydantes comme BCL-2, et peut-être TRP-2, est r eduite, et la d efense sp ecifique du syst eme antioxydant enzymatique faiblit a travers le follicule, r esultant en un plus grand stress oxydatif. Une r eduction marqu ee de l'expression catalase et les r esultats de l'activit e de l'accumulation millimolaire de peroxyde d'hydrog ene contribuent a un dysfonctionnement et a la mort des m elanocytes b...

show abstract

“…This is more likely in Caucasians than in Africans or Asians 68 . There is a progressive decline of melanocyte progenitor reservoir of the hair bulb.…”

Section: Greying Of Hairmentioning

confidence: 99%

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Arianayagam

Ryan

2016

Current Science

View full text Add to dashboard Cite

Biomedicine has not provided a complete explanation with fully effective therapies for disorders of pigmentation. Biomedicine emphasizes the role of melanocyte for protection from UV rays and as a determinant of skin colour. These important properties acquired a genetic basis much later than other functions, many relating to cell contact as in the keratinocyte -melanocyte unit, or as with the synapses of the neurological system. There are other roles, biochemical and mechanical, of melanocyte. Management that is inclusive of a maximally holistic approach justifies the use of diverse herbals, yoga and concern for cultural awareness provided by integrated medicine. Vitiligo provides a model which demonstrates that Ayurveda has a richer view of its presentations, possibly a stronger line on its pathogenesis, and a huge range of herbals, many now backed by studies from ethnobotanical laboratories, awaiting research into the many possible mechanisms by which they may act in the wide and complex field of melanocyte biochemistry.

show abstract

Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb

Abstract: Calculating the percentage of people showing at least 50% grey hair coverage at age 50 years leads to a global range of 6-23%, according to ethnic/geographical origin and natural hair colour: well below that expressed by the '50' rule of thumb.

Cited by 101 publications

References 20 publications

Age-related hair changes in men: Mechanisms and management of alopecia and graying

Age-related hair changes in men: Mechanisms and management of alopecia and graying

Age‐induced hair greying – the multiple effects of oxidative stress

Disorders of Pigmentation of the Skin - Hypotheses Underlying Interventions by Multiple Systems of Medicine:Is there a Role for Integrated Medicine?

Contact Info

Product

Resources

About