“…By definition, all classic cadherins bind the catenins and catenins are critical for synapse formation, but some cadherins have been shown to interact directly and indirectly with other synaptic proteins including glutamate receptors (AMPA, NMDA, and kainate type), scaffolding proteins (AKAP79/150, GRIP), and signaling molecules (Vangl2, p38 MAPK). 95,[107][108][109][110][111] Nonetheless, the precise signaling mechanisms used by cadherins during the process of synaptic specificity remain unknown. Another unresolved question is at what stage in synapse development are cadherins required?…”