Groundwater quality in Chennai city along the Cooum river, during the premonsoon (June–July) and postmonsoon (Dec–Jan) for three years, from 2009 to 2011, was analyzed. Groundwater samples were collected from 20 bore wells on either side of the river. The analysis focused on the determination of seven specific water quality parameters, namely, pH, EC, TDS, BOD, COD, Na and Pb, using standard procedures. The statistical analysis, like the mean and standard deviation, coefficient of variance, and correlation, and multilinear regression analysis of the obtained data were carried out. The analysis of the collected samples reveals that the stated water quality parameters have not complied with the WHO standards, and the water is not fit for drinking and domestic purposes. The correlation and multilinear regression analyses suggest that the conductivity has a significant correlation with the other six considered water quality parameters.