Group B Streptococcal Infection in Taiwan: Maternal Colonization and Neonatal Infection

Yu, Hsiu-Wen; Lin, Hsiao-Chuan; Yang, Ping-Feng; Hsu, Chyong-Hsin; Hsieh, Wu‐Shiun; Tsao, Lon-Yen; Chen, Chao-Huei; Lin, Hung‐Chih; Tseng, Ya-Chun

doi:10.1016/j.pedneo.2011.05.008

Cited by 29 publications

(32 citation statements)

References 15 publications

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“…GBS colonization rates in Chinese pregnant women have been reported to vary between regions. For example, the reported rate was 20% in Taiwan [10], 21.8% in Hong Kong [11], 7.1% in Beijing [12], and 36% in Shaanxi Province [13]. Worldwide, frequencies of maternal GBS colonization have been reported to range from 14–30% in developed countries [14] to 19% in the Sub-Saharan region [15] and 12–15% in India and Pakistan [16].…”

Section: Discussionmentioning

confidence: 99%

Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

et al. 2019

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Background: As no population-based studies of group B Streptococcus (GBS) colonization rates in late pregnancy (at 35–37 weeks of gestation) have been conducted in China, the incidence of and risk factors for neonatal early-onset GBS disease (GBS-EOD) in China remains poorly understood. Objectives: To determine the GBS colonization rate in late pregnancy and neonatal GBS infection in Xiamen, China, and to assess the effectiveness of intrapartum antibiotic prophylaxis (IAP) for the prevention of neonatal GBS-EOD. Methods: A total of 49,908 pregnant women were enrolled between April 1, 2014 and March 31, 2017. Bacterial culture was used to diagnose GBS infection in both pregnant women and neonates. Women with GBS colonization received IAP during parturition or rupture of fetal membranes. Results: The GBS colonization rate was 13.89% (6,933/49,908); 50,772 neonates were born to 49,908 pregnant women, of whom 75 (1.48 per 1,000) were diagnosed with GBS-EOD. The incidence of GBS-EOD among neonates born to GBS-positive mothers (8.77‰; 62/7,068) was 29 times higher than that of neonates born to GBS-negative mothers (0.30‰; 13/43,704). Logistic regression analysis indicated that gestational bacteriuria, GBS disease in infants from previous pregnancies, and chorioamnionitis were risk factors for GBS-EOD (p = 0.007, p = 0.000, and p = 0.018, respectively). IAP effectively protected against neonatal GBS-EOD (p = 0.011). Conclusions: GBS colonization was detected in nearly 14% of late pregnant women. The IAP for reducing GBS-EOD was effective. Therefore, universal screening of maternal GBS and subsequent IAP for those with GBS colonization should be implemented in China.

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Section: Discussionmentioning

confidence: 99%

Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

et al. 2019

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“…Maternal streptococcal colonization is associated with urinary tract infection, premature rupture of membrane (PROM), preterm labor, intrauterine fetal death and complications such as chorioamnionitis and endometritis (2). Pregnant women who are carriers of GBS have 50–60% potential capacity for vertical transmission of the microorganism, through which 1–2% of their newborns develop invasive GBS infection (1, 3), with 5–20% mortality rate and serious complications, especially among premature neonates (4, 5). Ethnicity, African origin, maternal age, parity, marital status, socio-economic status, education, occupation, geographic location, smoking, presence of sexually transmitted disease, sexual behavior, and high body mass index have been reported to influence the prevalence of colonization (2, 3, 6).…”

Section: Introductionmentioning

confidence: 99%

“…Pregnant women who are carriers of GBS have 50–60% potential capacity for vertical transmission of the microorganism, through which 1–2% of their newborns develop invasive GBS infection (1, 3), with 5–20% mortality rate and serious complications, especially among premature neonates (4, 5). Ethnicity, African origin, maternal age, parity, marital status, socio-economic status, education, occupation, geographic location, smoking, presence of sexually transmitted disease, sexual behavior, and high body mass index have been reported to influence the prevalence of colonization (2, 3, 6). The Centers for Disease Control and Prevention (CDC) currently recommend screening of all pregnant women for GBS between 35–37 weeks of gestation (2, 5, 7).…”

Section: Introductionmentioning

confidence: 99%

The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women

et al. 2017

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BackgroundGroup B Streptococcus (GBS) is a leading cause of serious neonatal infections. Although great progress has been made in preventing prenatal GBS, its colonization rate in different regions of Iran remains unknown.AimTo determine GBS colonization prevalence and its risk factors among Iranian pregnant women.MethodsThis prospective cross-sectional study was performed on 186 pregnant women, who attended Boo-Ali hospital which is affiliated with Islamic Azad University in Tehran, Iran, from March 2014 to June 2015. The demographic, obstetric and gynecological data were gathered. A recto-vaginal culture was taken from each patient, with a sterile swab, in lithotomy position without using speculum, and vaginal pH was measured. Patients with positive GBS received IV antibiotic therapy during labor (penicillin G 3 gram at first dose then 1.5 gram Q/4h until delivery). Data were analyzed by statistical software SPSS version 21. Statistical tests for differences were performed by Chi-square test. Potential confounding was assessed by logistic regression. Level of significance was set at p<0.05.ResultsTwenty-two (11.8%) patients had positive recto-vaginal colonization. No significant differences between colonized and GBS-negative women with regard to age, obstetrics history and socio-economic factor were noticed. In contrast, smoking, history of previous infection with HPV, presence of vulvitis and a vaginal pH>4.5 were associated with GBS colonization (p≤0.05).ConclusionsWith a relatively low prevalence and few significantly correlated factors, it is hardly possible to define a high risk group of pregnant women for GBS colonization. Therefore, thorough measures should be taken in order to prevent infection complications in mothers and neonates in the Iranian population.

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“…Early-onset disease (EOD) is characterized by the symptom onset during the first week of life (06 days), while late-onset disease (LOD) is characterized by the onset of symptoms up to three months of age (789 days) [1]. An invasive GBS infection is defined as GBS isolated from a normally sterile site such as blood or cerebrospinal fluid (CSF), or, less commonly, joint, pleural, or pericardial fluid [2].…”

Section: Introductionmentioning

confidence: 99%

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

Wang

Tong

et al. 2015

International Journal of Infectious Diseases

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Group B Streptococcal Infection in Taiwan: Maternal Colonization and Neonatal Infection

Abstract: We concluded that universal maternal rectovaginal culture of GBS with intrapartum antibiotic prophylaxis is an urgent call to reduce EOD and mortality because of GBS infection in neonates in Taiwan.

Cited by 29 publications

References 15 publications

Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

Group B Streptococcus Colonization in Late Pregnancy and Invasive Infection in Neonates in China: A Population-Based 3-Year Study

The prevalence and risk factors of group B streptococcus colonization in Iranian pregnant women

Serotype distribution, antimicrobial resistance, and molecular characterization of invasive group B Streptococcus isolates recovered from Chinese neonates

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