Growth curves in Down syndrome with congenital heart disease

Sica, Caroline D’Azevedo; Cesa, Cláudia Ciceri; Pellanda, Lúcia Campos

doi:10.1590/1806-9282.62.05.414

Cited by 5 publications

(6 citation statements)

References 17 publications

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“…9 2.4 | Risk factors associated with development of T21 and CHD There are discrepancies regarding gender and the risk of CHD in patients with T21, CHD being more frequently reported in females. 1,5,6,11 Other studies have suggested male predominance. 12 Prenatal factors associated with T21-CHD include maternal smoking (adjusted relative risk 1.57 [1.18-2.09]) and obesity (BMI > 30 kg/m 2 ) with a 16%-34% increased risk.…”

Section: Neurodevelopmental Outcome In Patients With Chd and T21mentioning

confidence: 95%

“…There are discrepancies regarding gender and the risk of CHD in patients with T21, CHD being more frequently reported in females . Other studies have suggested male predominance .…”

Section: Trisomy 21mentioning

confidence: 98%

“…There is a wide spectrum of CHD in patients with T21. Atrioventricular septal defect (AVSD) is the most frequent CHD in patients with T21 (30%-60%), [4][5][6]9,11,12 followed by atrial (16%-21%), 4,6,8,12 and ventricular septal defect (VSD) (14%-27%), [4][5][6]8,9,12 tetralogy of Fallot (2%-11%), 5,8,12 patent arterial duct (6%), 5 coarctation of aorta (CoA) (0.3%), 8 and bicuspid aortic valve (BAV) (0.5%-2%). 5,8 Some of the CHD lesions could be isolated or combined with other types of CHD.…”

Section: Spectrum Of Chd In Patients With T21mentioning

confidence: 99%

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Congenital heart disease and cardiac procedural outcomes in patients with trisomy 21 and Turner syndrome

Morales-Demori

2017

Congenital Heart Disease

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Congenital heart disease (CHD) is present in approximately 50% of patients with trisomy 21 (T21) and Turner syndrome (TS). According to the American Academy of Pediatrics, every patient with these genetic disorders should have a postnatal echocardiogram. T21 is usually associated with atrioventricular (30%-60%), atrial (16%-21%), or ventricular septal defects (14%-27%). TS is usually associated with left-sided heart disease. However, the spectrum of CHD in these genetic disorders is wider than those mentioned lesions. More cardiac surgical procedures are offered to these patients and that has influenced positively their life expectancy for some CHD conditions. Single ventricular anatomy is associated with high mortality in these genetic disorders (49% in T21 and 83%-91% in TS). The goal of this article is to describe the spectrum of CHD, screening guidelines, and cardiac surgical outcomes in patients with T21 or TS with CHD.

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Section: Neurodevelopmental Outcome In Patients With Chd and T21mentioning

confidence: 95%

“…There are discrepancies regarding gender and the risk of CHD in patients with T21, CHD being more frequently reported in females . Other studies have suggested male predominance .…”

Section: Trisomy 21mentioning

confidence: 98%

Section: Spectrum Of Chd In Patients With T21mentioning

confidence: 99%

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Congenital heart disease and cardiac procedural outcomes in patients with trisomy 21 and Turner syndrome

Morales-Demori

2017

Congenital Heart Disease

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“…Plotting a person on such DS specific curve only provide information about weight status compared to peers with DS and can classify a person with DS to be normal weight, that otherwise, by use of standard curves, would classify as overweight or obese (47). However, due to the shorter stature of individuals with DS, the curves and cut-offs developed for typical children have been found to overestimate obesity and percent body fat as measured by dualenergy X-ray absorptiometry (DXA) (48).…”

Section: Nutritional Statusmentioning

confidence: 99%

Nutritional challenges in children and adolescents with Down syndrome

Nordstrøm

Retterstøl

Hope

et al. 2020

The Lancet Child & Adolescent Health

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Several features and comorbidities in DS have nutritional implications and consequences, which needs to be addressed in further detail. In this review, we searched and assessed the literature from year 2000-2019 and found in total 57 nutritionally relevant articles.In infancy and early childhood, children with DS have high risk of oral motor difficulties and pharyngeal dysphagia with aspiration, which requires systematic attention. To improve nutritional status in children with underweight and clinical signs of feeding problems further evaluation of underlying causes is required. Clinical interventions should promote swallowing safety and development of feeding abilities.Already from 4-5 years of age overweight may become a concern. To prevent disease later in life, there is an urgent need for more research on nutritional aspects in prevention and treatment of obesity for adolescents with DS. The present review did not find any data to support the use of dietary supplementation except when deficiency is documented. In addition, the literature presented clearly documents the need for more research using larger study samples, and control groups, addressing important nutritional challenges in children and adolescents with DS.

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“…In adolescence and adulthood, patients with DS have a higher prevalence of overweight and obesity. Malnutrition followed by overweight and obesity may enhance risk to cardiovascular health compared to maintaining the same nutrition status over a period of time [130]. Use of DS specific growth charts are important for nutrition screening to accurately assess for both undernutrition and overweight/obesity and therefore to design a more targeted intervention [125].…”

Section: Nutrition Considerationsmentioning

confidence: 99%

Down syndrome and congenital heart disease: perioperative planning and management

Delany

Gaydos

Romeo

et al. 2021

J Congenit Heart Dis

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Approximately 50% of newborns with Down syndrome have congenital heart disease. Non-cardiac comorbidities may also be present. Many of the principles and strategies of perioperative evaluation and management for patients with congenital heart disease apply to those with Down syndrome. Nevertheless, careful planning for cardiac surgery is required, evaluating for both cardiac and noncardiac disease, with careful consideration of the risk for pulmonary hypertension. In this manuscript, for children with Down syndrome and hemodynamically significant congenital heart disease, we will summarize the epidemiology of heart defects that warrant intervention. We will review perioperative planning for this unique population, including anesthetic considerations, common postoperative issues, nutritional strategies, and discharge planning. Special considerations for single ventricle palliation and heart transplantation evaluation will also be discussed. Overall, the risk of mortality with cardiac surgery in pediatric patients with Down syndrome is no more than the general population, except for those with functional single ventricle heart defects. Underlying comorbidities may contribute to postoperative complications and increased length of stay. A strong understanding of cardiac and non-cardiac considerations in children with Down syndrome will help clinicians optimize perioperative care and long-term outcomes.

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Growth curves in Down syndrome with congenital heart disease

Cited by 5 publications

References 17 publications

Congenital heart disease and cardiac procedural outcomes in patients with trisomy 21 and Turner syndrome

Congenital heart disease and cardiac procedural outcomes in patients with trisomy 21 and Turner syndrome

Nutritional challenges in children and adolescents with Down syndrome

Down syndrome and congenital heart disease: perioperative planning and management

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