Land spaces function in capacities of urban development, agricultural production, and ecological conservation, among many others. Research of land space utilization efficiency (LSUE) and coupling coordination relationships among its subsystems are significant for sustainable land space development. In this study, taking the Urban Agglomeration in the Middle Reaches of the Yangtze River (UAMRYR) as the study area, we establish a measurement index system to evaluate the LSUE (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) and analyze its coupling coordination degree by utilizing an improved coupling coordination model. The main results include the following. (1) The average efficiency levels of urban space and agricultural space in the UAMRYR increased 2000-2018, while the average efficiency of ecological space declined. (2) The spatial pattern of the LSUE values varied greatly, with the distributions of high-efficiency and low-efficiency levels significantly different. (3) The coupling degree of LSUE includes three types, i.e., high-level coupling, break-in, and antagonism. Each coupling degree type was characterized by change over time. (4) The proportion of areas with high coupling coordination and moderate coupling coordination increased from 2000 to 2018, while the proportion of areas with basic coupling coordination, moderate imbalance, and serious imbalance declined during this period. Given that the spatial differentiation of the LSUE and its coupling coordination, it is necessary to implement a differential land space development strategy in the UAMRYR. This study is helpful to promote the efficient utilization and coordinated development of land space utilization systems.