Growth impairment of children with different types of lip and palate clefts in the first 2 years of life: a cross-sectional study

Montagnoli, Luiz Carlos; Barbieri, Marco Antônio; Bettiol, Heloísa; Marques, Inara; Souza, Luiz de

doi:10.2223/jped.1420

Cited by 59 publications

(93 citation statements)

References 24 publications

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“…The majority of studies reporting growth of children with clefts detected physical growth deficiencies in length and weight for children with CLP and ICP, especially during the first year of life when the primary palatoplasty had not yet been done (Seth and McWilliams, 1998;Day, 1985;Jones, 1988;Pandya and Booman, 2001;Lee et al, 1996;Montagnoli et al, 2005). Growth deficiency observed during this period has been attributed to environmental factors including the high frequency of infectious diseases (Seth and McWilliams, 1998) and the different degrees of difficulties encountered to feed the children with cleft palate (Drillen et al, 1966;Coy et al, 2000;Montagnoli et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

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Longitudinal study of growth of children with unilateral cleft-lip palate from birth to two years of age

Marques¹,

Garla²,

Neto³

et al. 2009

The Cleft Palate-Craniofacial Journal

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Objective-To study the growth of children with complete unilateral cleft lip and palate (UCLP) from birth to 2 years of age and to construct specific UCLP growth curves.Design-Physical growth was a secondary outcome measure of a NIH sponsored longitudinal, prospective clinical trial involving the University of Florida (USA) and the University of São Paulo (Brazil).Patients-627 children with UCLP, nonsyndromic, both genders.Methods-Length, weight, and head circumference were prospectively measured for a group of children enrolled in a clinical trial. Median growth curves for the 3 parameters (length, weight, head circumference) were performed and compared to the median for the National Center for Health Statistics (NCHS, 2000) curves. The median values for length, weight, and head circumference at birth, 6, 12, 18 and 24 month of age were plotted against NCHS median values, and statistically compared at birth and 24 months. Results-At birth, children of both genders with UCLP presented with smaller body dimensions in relation to NCHS median values, but the results suggest a "catch up growth" for length, weight, and head circumference for girls and for weight (to some degree) and head circumference for boys. Setting-HospitalConclusions-Weight was the most compromised parameter for both genders followed by length and then head circumference. There was no evidence of short statue. This study established growth curves for children with UCLP. Many physical growth studies of children with CLP have been published (Bowers et al., 1987;Felix-Schollaart et al., 1992;Ross and Jhonston, 1972; Cunninghan and Jerome, 1997;Becker et al., 1998; Montagnoli et al., 2005, Gopinath andMuda, 2005). Although the results vary between different investigators, most of them state that these children are smaller and lighter than the control subjects, mainly during the first years of age. A catch up growth may occur later in childhood (Ross and Jhonston, 1972; Lee et al., 1996). KeywordsMany factors such as feeding problems and recurrent respiratory infections have been suggested to negatively impact normal growth. Reports indicate that growth problems are more severe in early infancy and are more frequent in children with isolated cleft palate (ICP), and cleft lip and palate (CLP), than in children with isolated cleft lip or normal (unaffected) children (Felix-Schollaart et al., 1992; Lee et al., 1996, Montagnoli et al., 2005.The limitations of previous growth studies include relatively small number of children included in their sample, possible inclusion of children with chronic health conditions and syndromes, and inclusion of different types of clefts or age ranges. Most studies were retrospective.This article is part of a series of studies that summarize an eleven-year prospective randomized clinical trial. The objective of this paper was to analyze the physical growth of the large sample of nonsyndromic children with unilateral cleft lip and palate (UCLP), from birth to two years of age, according to gender, in a longitudinal...

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Section: Discussionmentioning

confidence: 99%

“…Reports indicate that growth problems are more severe in early infancy and are more frequent in children with isolated cleft palate (ICP), and cleft lip and palate (CLP), than in children with isolated cleft lip or normal (unaffected) children (Felix-Schollaart et al, 1992; Lee et al, 1996, Montagnoli et al, 2005.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of growth of children with unilateral cleft-lip palate from birth to two years of age

Marques¹,

Garla²,

Neto³

et al. 2009

The Cleft Palate-Craniofacial Journal

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“…Some congenital anomalies such as cleft lip and palate, although not associated with genetic syndromes, alter the child's normal genetic growth potential, for significantly interfering with breastfeeding and the intake of nutrients in the first months of life, and triggering growth deficit in this period (23) . As for Down Syndrome, it is important to note that children with this genetic abnormality usually have thyroid disorders, and muscular hypotonia, which can determine body composition and expected weight gain differently from those considered normal (24) .…”

Section: Risk Criteria and Reflections On The Growth Processmentioning

confidence: 99%

Bebê de risco: acompanhando o crescimento infantil no primeiro ano de vida

Sassá¹,

Higarashi

Bercini

et al. 2011

Acta paul. enferm.

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Objective: To monitor the growth of high-risk babies in the first year of life. Methods: Analytical, cohort study, conducted with 237 babies born in Maringá -PR, between May 1 to October 31, 2008, under the Program for the Surveillance of At-Risk Infants. Results: Growth changes were present in 188 (79.3%) infants and occurred mainly after the first trimester of life. A slower than expected growth rate showed statistical association with maternal age of less than 18 years, education of less than 8 years, presence of congenital anomalies, and birth weight greater than or equal to 2,500g born at term. Conclusion: The evaluation of growth in at-risk infants should include a multidimensional analysis, considering the biological and maturational aspects of each specific risk condition, and adaptation of the baby and his/her family on this evolutionary path. Keywords: Maternal-child nursing; Child health; Growth; Risk factors RESUMO Objetivo: Acompanhar o crescimento de bebês de risco no primeiro ano de vida. Métodos: Estudo analítico, do tipo coorte, realizado com 237 bebês nascidos em Maringá -PR, entre 1º de maio a 31 de outubro de 2008, incluídOs no Programa de Vigilância do Bebê de Risco. Resultados: As alterações de crescimento estiveram presentes em 188 (79,3%) bebês e ocorreram sobretudo, após o 1º trimestre de vida. A velocidade de crescimento abaixo da esperada apresentou associação estatística com idade materna menor que 18 anos, tempo de estudo inferior a 8 anos, presença de anomalia congênita, peso ao nascer maior ou igual a 2.500g e nascimento a termo. Conclusão: A avaliação do crescimento dos bebês de risco deve abarcar uma análise multidimensional, considerando os aspectos biológicos e maturacionais específicos a cada condição de risco e a adaptação do bebê e de sua família nesse percurso evolutivo. Descritores: Enfermagem materno-infantil; Saúde da criança; Crescimento; Fatores de risco RESUMEN Objetivo: Acompañar el crecimiento de bebés de riesgo en el primer año de vida. Métodos: Se trata de un estudio analítico, de tipo cohorte, realizado con 237 bebés nacidos en Maringá -PR, entre el 1º de mayo al 31 de octubre del 2008, incluídos en el Programa de Vigilancia del Bebé de Riesgo. Resultados: Las alteraciones de crecimiento estuvieron presentes en 188 (79,3%) bebés y ocurrieron sobre todo, después del 1º trimestre de vida. La velocidad de crecimiento debajo de la esperada presentó asociación estadística con edad materna menor de 18 años, tiempo de estudio inferior a 8 años, presencia de anomalía congénita, peso al nacer mayor o igual a 2.500 gr. y nacimiento a término. Conclusión: La evaluación del crecimiento de los bebés de riesgo debe abarcar un análisis multidimensional, considerando los aspectos biológicos y de madurez específicos a cada condición de riesgo y la adaptación del bebé y su familia en ese recorrido evolutivo.

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“…There are also case reports of pituitary hormone deficiencies in children and adults who have isolated or syndromic orofacial median clefts (8,9). Only in a few studies were endocrine abnormalities associated with midline cerebral and/or facial anomalies investigated in pediatric patients (10)(11)(12)(13)(14)(15). However, in these studies, the study population was derived from patients who were referred to an endocrinology unit and already had clinical findings of abnormal endocrine functions.…”

Section: Introductionmentioning

confidence: 99%

Endocrine abnormalities of patients with cleft lip and/or cleft palate during the neonatal period

Akın¹,

Kurtoğlu²,

Sarıcı³

et al. 2014

Turk J Med Sci

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IntroductionCultivated strawberry, Fragaria × ananassa, is the natural hybrid of F. chiloensis and F. virginiana and is thought to be only about 300 years old (Hancock, 1999). Earlier researchers have reported that the cultivated strawberry has very narrow genetic diversity when compared with its progenitor species (Dale and Sjulin, 1990;Hancock, 2006;Horvath et al., 2011). Since the progenitor species can easily be crossed with the cultivated strawberry, several attempts have been made to utilize the wild species to expand the genetic base of cultivated strawberry. An example of successful utilization of the wild species includes the introgression of day-neutrality from F. virginiana subsp.

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Growth impairment of children with different types of lip and palate clefts in the first 2 years of life: a cross-sectional study

Abstract: The impairment in weight and length was more severe in cleft lip + palate and isolated cleft palate children and may be attributed to feeding difficulties compared to the isolated cleft lip group.

Cited by 59 publications

References 24 publications

Longitudinal study of growth of children with unilateral cleft-lip palate from birth to two years of age

Longitudinal study of growth of children with unilateral cleft-lip palate from birth to two years of age

Bebê de risco: acompanhando o crescimento infantil no primeiro ano de vida

Endocrine abnormalities of patients with cleft lip and/or cleft palate during the neonatal period

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