Growth Inhibition of Human Non-Small Lung Cancer Cells H460 By Green Tea and Ginger Polyphenols

Hessien, Mohamed; El-Gendy, Saad M.; Donia, Thoria; Sikkena, Morsy Abou

doi:10.2174/187152012800228698

Cited by 15 publications

(10 citation statements)

References 18 publications

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“…Polyphenols exert a wide range of beneficial effects beyond their antioxidant and anti-inflammatory properties [ 13 , 14 , 15 ]. Data evidence from in vitro [ 16 , 17 , 18 , 19 , 20 ] and in vivo studies [ 21 , 22 , 23 , 24 ] suggest the chemoprotective role of polyphenols against lung carcinogenesis probably resulting from three main mechanisms: antioxidant activity, regulation of phase I and II enzymes and regulation of cell survival pathways [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

Delgado-Roche¹,

Santes-Palacios

Herrera

et al. 2020

Marine Drugs

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The aim of the present work was to evaluate the effects of Thalassia testudinum hydroethanolic extract, its polyphenolic fraction and thalassiolin B on the activity of phase I metabolizing enzymes as well as their antimutagenic effects. Spectrofluorometric techniques were used to evaluate the effect of tested products on rat and human CYP1A and CYP2B activity. The antimutagenic effect of tested products was evaluated in benzo[a]pyrene (BP)-induced mutagenicity assay by an Ames test. Finally, the antimutagenic effect of Thalassia testudinum (100 mg/kg) was assessed in BP-induced mutagenesis in mice. The tested products significantly (p < 0.05) inhibit rat CYP1A1 activity, acting as mixed-type inhibitors of rat CYP1A1 (Ki = 54.16 ± 9.09 μg/mL, 5.96 ± 1.55 μg/mL and 3.05 ± 0.89 μg/mL, respectively). Inhibition of human CYP1A1 was also observed (Ki = 197.1 ± 63.40 μg/mL and 203.10 ± 17.29 μg/mL for the polyphenolic fraction and for thalassiolin B, respectively). In addition, the evaluated products significantly inhibit (p < 0.05) BP-induced mutagenicity in vitro. Furthermore, oral doses of Thalassia testudinum (100 mg/kg) significantly reduced (p < 0.05) the BP-induced micronuclei and oxidative damage, together with an increase of reduced glutathione, in mice. In summary, Thalassia testudinum metabolites exhibit antigenotoxic activity mediated, at least, by the inhibition of CYP1A1-mediated BP biotransformation, arresting the oxidative and mutagenic damage. Thus, the metabolites of T. testudinum may represent a potential source of chemopreventive compounds for the adjuvant therapy of cancer.

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Section: Introductionmentioning

confidence: 99%

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

Delgado-Roche¹,

Santes-Palacios

Herrera

et al. 2020

Marine Drugs

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“…Various phytochemicals in the tea, such as flavonoids, tannins, and catechins, are important daily antioxidants for millions of people and may provide additional health benefits. Regular consumption of green tea may contribute to a reduction in cardiovascular disease and some cancers [1][2][3][4]. Improving the quality of this important beverage is a long-term objective of the agricultural and food industries.…”

Section: Introductionmentioning

confidence: 99%

Effects of Additive β-Cyclodextrin on the Performances of Green Tea Infusion

Dai

Liu

Jin

et al. 2019

Journal of Chemistry

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The effects of the added β-cyclodextrin (β-CD) in the tea infusion extraction on color quality of green tea (Camellia sinensis) infusion have been investigated in detail. Due to the added β-CD, the color of the tea infusion can be brightened effectively, and meanwhile, compared to conventional extraction, the retentions of tea polyphenols, catechins, and chlorophyll have also been proved to be increased greatly. Furthermore, the additive β-CD can also increase the viscosity of the tea infusion. In addition, the existing β-CD can lower the oxygen solubility ratio in tea infusions effectively, from which a high-quality tea infusion can be prepared ready for further processing.

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“…Green tea polyphenols defend healthy cells from malignant transformation and induce apoptosis locally in oral cancer cells (33). Polyphenols extracted from both green tea and ginger showed antiproliferative and apoptosis-mediated cytotoxic effects on human non-small lung cancer cells (34). Polyphenols and sterols extracted from virgin argan oil have also shown antiproliferative and pro-apoptotic effects on human prostate cancer cell lines (35).…”

Section: Dietary Polyphenols and Cancersmentioning

confidence: 99%

The beneficial and deleterious role of dietary polyphenols on chronic degenerative diseases by regulating gene expression

Chen

Guo

2018

BST

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Dietary polyphenols, a natural component in many kinds of foods such as fruits and vegetables, play essential roles in a wide range of plant functions. Importantly, the discovery of the functions of polyphenols including anti-oxidant, anti-carcinogenic and anti-inflammatory has been appealing to researchers' attentions. Dietary polyphenols have shown protective effects on chronic degenerative diseases (CDD) such as cardiovascular diseases, cancers, and neurodegenerative diseases by regulating gene expression. Dietary polyphenols also affect the composition and activity of gut microbiota, in reverse, gut microbiota influences the bioavailability and physiological activity of dietary polyphenols. However, not all kinds of dietary polyphenols are beneficial for human health. The potential deleterious effects of several dietary polyphenols have been reported by inducing DNA damage and gene mutants. This review summarizes the potential therapeutic effects of dietary polyphenols on chronic degeneration diseases, the polyphenols-gut microbiota interactions, and the potential dangers of individual dietary polyphenols on human health.

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Growth Inhibition of Human Non-Small Lung Cancer Cells H460 By Green Tea and Ginger Polyphenols

Abstract: The study reports the antiproliferative and apoptosis-mediated cytotoxic effects of green tea and ginger polyphenolic extracts on human H460 cell line, indicating their promising chemopreventive effect against lung cancer.

Cited by 15 publications

References 18 publications

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

Effects of Additive β-Cyclodextrin on the Performances of Green Tea Infusion

The beneficial and deleterious role of dietary polyphenols on chronic degenerative diseases by regulating gene expression

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