Growth-inhibitory Responses of Human Intestinal Bacteria to Extracts of Oriental Medicinal Plants

Ahn, Y-J.; Kwon, J-H.; Chae, S-H.; Jh, Park; Yoo, Jisu

doi:10.3109/08910609409141363

Cited by 10 publications

(2 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The growth responses of test samples were determined by making a comparison with those of the controls. The inhibitory responses were classified as previously described ( , ): inhibitory zone diameter >30 mm, ++++; 21−30 mm, +++; 16−20 mm, ++; 10−15 mm, +; and <10 mm, −.…”

Section: Methodsmentioning

confidence: 99%

Selective Growth Inhibitor toward Human Intestinal Bacteria Derived from Pulsatilla cernua Root

Lee

Beon

Kim

2001

J. Agric. Food Chem.

View full text Add to dashboard Cite

Among 21 medicinal plants, the growth-inhibiting activity of Pulsatilla cernua root-derived materials toward human intestinal bacteria was examined by using an impregnated paper disk method. The biologically active components of P. cernua roots were characterized as 4-hydroxy-3-methoxycinnamic acid and 3,4-dihydroxycinnamic acid by spectroscopic analysis. The activity was compared with that of six commercially available cinnamic acid derivatives trans-cinnamaldehyde, trans-cinnamic acid, cinnamyl alcohol, 2-methoxycinnamic acid, 3-methoxycinnamic acid, and 4-methoxycinnamic acid. The growth responses varied with each bacterial strain tested. Two isolated compounds revealed a potent inhibition against Clostridium perfringens, and moderate to weak activity against Escherichia coli was exhibited by 4-hydroxy-3-methoxycinnamic acid. Weak or no inhibitory activity was obtained against the bifidobacteria or Lactobacillus acidophilus. The inhibitory effect was much more pronounced in C. perfringens and E. coli as compared to B. adolescentis, B. bifidum, B. fragilis, B. longum, or L. acidophilus. Cinnamaldehyde exhibited a strong growth-inhibiting activity, but no inhibition was observed from treatments with trans-cinnamic acid, cinnamyl alcohol, 2-methoxycinnamic acid, 3-methoxycinnamic acid, and 4-methoxycinnamic acid. These results may be an indication of at least one of the pharmacological actions of P. cernua root.

show abstract

Section: Methodsmentioning

confidence: 99%

Selective Growth Inhibitor toward Human Intestinal Bacteria Derived from Pulsatilla cernua Root

Lee

Beon

Kim

2001

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…Use of medicinal plants can be important for prevention of human diseases induced by intestinal microorganisms: over change in their number, composition of communities and production of potentially harmful metabolites (Ahn et al, 1994). Extract from roots of Aralia has antifungal effect against Pyricularia grisea and antibacterial activity towards gram-positive bacilli.…”

Section: Introductionmentioning

confidence: 99%

Effect of alcohol tincture of Aralia elata on the organism of rats and their gut microbiota against the background of excessive fat diet

Brygadyrenko

Lieshchova

Bilan

et al. 2019

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

Pharmacological effects of the medicinal plant Aralia elata (Miq.) Seem. 1868 (Araliaceae) are related to presence of over 150 secondary metabolites, including flavonoids, sterols, polysaccharides, terpenoid saponins and terpenoid acids, though the main biologically active substances of A. elata are saponins and flavonoids. Some clinical tests and experimental studies have proved the influence of A. elata on the organism through increase in physical work capacity, exerting an anti-stress effect against a broad range of harmful factors, including stress from cold, immobilization, ultraviolet radiation and low pressure. The literature also reports the anti-ulcer, anti-secretory, antifungal, anti-tumour, and antimicrobial activity of preparations from this plant. In our laboratory experiment, we determined that ethanolic tincture of A. elata has no effect on the intensity of growth of body weight of young rats against the background of excessive content of fat in their diet. Excessive fat-feeding of male rats leads mostly to disorders in the functioning of the liver and development of steatosis. This was accompanied by reduction in relative mass of the liver, increase in activity of hepatic enzymes, dysproteinemia, increase in the level of bilirubin and decrease in the level of urea. Additional use of 0.1% ethanol led to impaired functioning of the kidneys, reduction of their relative mass, signs of dehydration, increase in the level of creatinine and total calcium in the blood. Use of ethanolic tincture of A. elata mitigates negative excess of fat, is accompanied by normalization of indices of mass of the organs, less notable dysproteinemia, impairment in the level of creatinine, glucose, urea, cholesterol, bilirubin and total calcium. Ethanolic tincture of A. elata has a low immunosuppressive action, against the background of a high fat diet it leads to increase in the amount of typical Escherichia сoli, decrease in Еnterococcus spp. and Enterobacter spp., significant decrease and in high concentrations (0.1% ethanolic tincture of A. elata) elimination of bacteria of Clostridium and Klebsiella genera, and also various yeast fungi in the intestine. In the examined male rats, against the background of excess of fat in the diet, no serious changes in the composition of the normal gut microbiota (Bifidobacterium spp., Lactobacillus spp., Proteus spp., Staphylococcus spp., Candida spp.) was observed, nor were any lactose-negative enterobacteria (Citrobacter genus) found. Perspectives of further research include determining histological, histochemical and immune-histological changes in the organs of laboratory animals under the effect of ethanolic tincture of A. elata following excessive accumulation of fat.

show abstract

Rhus chinensis and Galla Chinensis – folklore to modern evidence: review

Djakpo

Yao

2010

Phytotherapy Research

157

View full text Add to dashboard Cite

The species Rhus chinensis Mill. (Anacardiaceae) is an important representative of the genus Rhus, which contains over 250 individual species found in temperate and tropical regions worldwide. Rhus chinensis has long been used by folk medicine practitioners in Asia. Leaves, roots, stem, bark, fruit and particularly the galls on Rhus chinensis leaves, Galla chinensis, are recognized to have preventative and therapeutic effects on different ailments (such as diarrhea, dysentery, rectal and intestinal cancer, diabetes mellitus, sepsis, oral diseases and inflammation). However, it is critical to separate evidence from anecdote. Fortunately, recent scientific research has revealed that Rhus chinensis compounds possess strong antiviral, antibacterial, anticancer, hepatoprotective, antidiarrheal and antioxidant activities. Moreover, compounds isolated from the stem of Rhus chinensis significantly suppressed HIV-1 activity in vitro. Compounds from this plant were also found to inhibit enamel demineralization in vitro and enhance remineralization of dental enamel with fluoride. This review highlights claims from traditional and tribal medicinal lore and makes a contemporary summary of phytochemical, biological and pharmacological findings on this plant material. It aims to show that the pharmaceutical potential of this plant deserves closer attention.

show abstract

Growth-inhibitory Responses of Human Intestinal Bacteria to Extracts of Oriental Medicinal Plants

Cited by 10 publications

References 13 publications

Selective Growth Inhibitor toward Human Intestinal Bacteria Derived from Pulsatilla cernua Root

Selective Growth Inhibitor toward Human Intestinal Bacteria Derived from Pulsatilla cernua Root

Effect of alcohol tincture of Aralia elata on the organism of rats and their gut microbiota against the background of excessive fat diet

Rhus chinensis and Galla Chinensis – folklore to modern evidence: review

Contact Info

Product

Resources

About